Acute Hypercalcemia Following Excessive Calcium Supplementation in a Dehydrated Patient With Progressive Multiple Sclerosis: Vitamin D Supplementation Is a Red Herring

Hanwell HE, Kimball SM. — Fri, 01 Jun 2012 00:00:00 GMT

Marcus et al described a patient with progressive multiple sclerosis presenting with symptomatic hypercalcemia. As emphasized by the title of their article, the authors concluded that hypercalcemia was at least partly due to vitamin D toxicity. We disagree. Vitamin D did not play a role in this case of hypercalcemia. Rather, the patient's clinical and biochemical presentation, and especially the successful resolution simply by rehydrating with saline, is entirely consistent with a dehydrated patient who consumed excessive calcium.

Acute Hypercalcemia Following Excessive Calcium Supplementation in a Dehydrated Patient With Progressive Multiple Sclerosis: Vitamin D Supplementation Is a Red Herring—Reply

Marcus JF, Goodin DS, Harris CA, et al. — Fri, 01 Jun 2012 00:00:00 GMT

In reply

JAMA Neurology: Acid Base, Electrolytes Topic Collection

Acute Hypercalcemia Following Excessive Calcium Supplementation in a Dehydrated Patient With Progressive Multiple Sclerosis: Vitamin D Supplementation Is a Red Herring

Acute Hypercalcemia Following Excessive Calcium Supplementation in a Dehydrated Patient With Progressive Multiple Sclerosis: Vitamin D Supplementation Is a Red Herring—Reply