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Observation | June 17, 2013 
Successful Treatment of Anti-Caspr2 Syndrome by Interleukin 6 Receptor Blockade Through Tocilizumab
Christos Krogias, MD; Robert Hoepner, MD; Andre Müller, MD; Christiane Schneider-Gold, MD; Alexandra Schröder, MD; Ralf Gold, MD
ImportanceImportance A patient with a Caspr2 autoantibodies–associated syndrome had an unusual clinical triad and an excellent response to B-cell–anergizing therapy using the ...
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JAMA Neurol. Published online June 17, 2013. doi:10.1001/jamaneurol.2013.143
Neurological Review | June 17, 2013 
The Neglected Neglect:  Auditory Neglect
Sankalp Gokhale, MD; Sourabh Lahoti, MD; Louis R. Caplan, MD
Whereas visual and somatosensory forms of neglect are commonly recognized by clinicians, auditory neglect is often not assessed and therefore neglected. The ...
JAMA Neurol. Published online June 17, 2013. doi:10.1001/jamaneurol.2013.155
Original Contribution | June 17, 2013 
Dissociable Effects of Alzheimer Disease and White Matter Hyperintensities on Brain Metabolism
Thaddeus J. Haight, PhD; Susan M. Landau, PhD; Owen Carmichael, PhD; Christopher Schwarz, PhD; Charles DeCarli, MD; William J. Jagust, MD; for the Alzheimer's Disease Neuroimaging Initiative
ImportanceImportance Cerebrovascular disease and Alzheimer disease (AD) frequently co-occur and seem to act through different pathways in producing dementia.ObjectiveObjective To examine cerebrovascular ...
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JAMA Neurol. Published online June 17, 2013. doi:10.1001/jamaneurol.2013.1878
Editorial | June 17, 2013 
Food for Thought
Deborah Blacker, MD, ScD
In this month's issue, the article by Hanson and colleagues1 makes a serious effort to understand whether dietary factors can affect the ...
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JAMA Neurol. Published online June 17, 2013. doi:10.1001/jamaneurol.2013.3288
Original Contribution | June 17, 2013  FREE
Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides:  Randomized Clinical Trial
Angela J. Hanson, MD; Jennifer L. Bayer-Carter, PhD; Pattie S. Green, PhD; Thomas J. Montine, MD, PhD; Charles W. Wilkinson, PhD; Laura D. Baker, PhD; G. Stennis Watson, PhD; Laura M. Bonner, PhD; Maureen Callaghan, MD; James B. Leverenz, MD; Elaine Tsai, MD; Nadia Postupna, PhD; Jing Zhang, PhD; Johanna Lampe, PhD; Suzanne Craft, PhD
Includes: Supplemental Content
ImportanceImportance Sporadic Alzheimer disease (AD) is caused in part by decreased clearance of the β-amyloid (Aβ) peptide breakdown products. Lipid-depleted (LD) apolipoproteins ...
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JAMA Neurol. Published online June 17, 2013. doi:10.1001/jamaneurol.2013.396
Images in Neurology | June 10, 2013 
Extensive Cerebral Venous Thrombosis
Sarah Nelson, MD; Bryan Ho, MD
A 50-year-old man with a history of hyperlipidemia presented with worsening headache following a motor vehicle crash that had caused a closed ...
JAMA Neurol. Published online June 10, 2013. doi:10.1001/jamaneurol.2013.1952
Original Contribution | June 10, 2013 
Blood Pressure and Progression of Brain Atrophy:  The SMART-MR Study
Hadassa M. Jochemsen, MD; Majon Muller, MD, PhD; Frank L. Visseren, MD, PhD; Philip Scheltens, MD, PhD; Koen L. Vincken, PhD; Willem P. Mali, MD, PhD; Yolanda van der Graaf, MD, PhD; Mirjam I. Geerlings, PhD; for the SMART Study Group
Includes: Supplemental Content
ImportanceImportance Studies have shown that both high and low blood pressure (BP) may play a role in the etiology of brain atrophy. ...
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JAMA Neurol. Published online June 10, 2013. doi:10.1001/jamaneurol.2013.217
Original Contribution | June 10, 2013 
Fragile X–Associated Tremor/Ataxia Syndrome:  Influence of the FMR1 Gene on Motor Fiber Tracts in Males With Normal and Premutation Alleles
Jun Yi Wang, PhD; David Hessl, PhD; Andrea Schneider, PhD; Flora Tassone, PhD; Randi J. Hagerman, MD; Susan M. Rivera, PhD
Includes: Supplemental Content
ImportanceImportance Individuals with the fragile X premutation express expanded CGG repeats (repeats 55-200) in the FMR1 gene and elevated FMR1 messenger RNA ...
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JAMA Neurol. Published online June 10, 2013. doi:10.1001/jamaneurol.2013.2934
Original Contribution | June 10, 2013 
Cingulate Epilepsy:  Report of 3 Electroclinical Subtypes With Surgical Outcomes
Rafeed Alkawadri, MD; Norman K. So, MD; Paul C. Van Ness, MD; Andreas V. Alexopoulos, MD, MPH
ImportanceImportance The literature on cingulate gyrus epilepsy in the magnetic resonance imaging era is limited to case reports and small case series. ...
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JAMA Neurol. Published online June 10, 2013. doi:10.1001/jamaneurol.2013.2940
Observation | June 10, 2013 
Serotonin Syndrome Associated With Clozapine Withdrawal
Elizabeth Stevenson, MD, MS; Frank Schembri, MD; Deborah M. Green, MD; Joseph D. Burns, MD
ImportanceImportance We describe a case of serotonin syndrome secondary to clozapine withdrawal and concomitant use of citalopram hydrobromide, a phenomenon that has ...
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JAMA Neurol. Published online June 10, 2013. doi:10.1001/jamaneurol.2013.95
Original Contribution | June 3, 2013 
Interleukin 17F Level and Interferon Beta Response in Patients With Multiple Sclerosis
Hans-Peter Hartung, MD; Lawrence Steinman, MD; Douglas S. Goodin, MD; Giancarlo Comi, MD; Stuart Cook, MD; Massimo Filippi, MD; Paul O’Connor, MD; Douglas R. Jeffery, MD; Ludwig Kappos, MD; Robert Axtell, MS, PhD; Volker Knappertz, MD; Timon Bogumil, MD; Susanne Schwenke, PhD; Ed Croze, PhD; Rupert Sandbrink, MD, PhD; Christopher Pohl, MD
Includes: Supplemental Content
ImportanceImportance High serum levels of interleukin 17F (IL-17F) at baseline have been associated with suboptimal response to interferon beta in patients with ...
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JAMA Neurol. Published online June 03, 2013. doi:10.1001/jamaneurol.2013.192
Original Contribution | June 3, 2013 
Long-term Outcomes After Nonlesional Extratemporal Lobe Epilepsy Surgery
Katherine Noe, MD; Vlastimil Sulc, MD; Lily Wong-Kisiel, MD; Elaine Wirrell, MD, FRCPC; Jamie J. Van Gompel, MD; Nicholas Wetjen, MD; Jeffrey Britton, MD; Elson So, MD; Gregory D. Cascino, MD; W. Richard Marsh, MD; Fredric Meyer, MD; Daniel Horinek, MD, PhD; Caterina Giannini, MD; Robert Watson, MD; Benjamin H. Brinkmann, PhD; Matt Stead, MD, PhD; Gregory A. Worrell, MD, PhD
ImportanceImportance A focal lesion detected by use of magnetic resonance imaging (MRI) is a favorable prognostic finding for epilepsy surgery. Patients with ...
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JAMA Neurol. Published online June 03, 2013. doi:10.1001/jamaneurol.2013.209
Observation | June 3, 2013 
Elevated CSF Cytokines in the Jarisch-Herxheimer Reaction of General Paresis
Larry E. Davis, MD; Ryan Oyer, MD; J. David Beckham, MD; Kenneth L. Tyler, MD
ImportanceImportance The Jarisch-Herxheimer reaction (JHR) is a well-recognized transient worsening of signs and symptoms occurring soon after the first dose of an ...
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JAMA Neurol. Published online June 03, 2013. doi:10.1001/jamaneurol.2013.2120
Viewpoint | June 3, 2013 
Neurologists:  The Last Bedside Physician-Scientists
Joseph R. Berger, MD
Over the course of nearly 40 years in medicine, I have had the opportunity to see an evolution in the practice of ...
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JAMA Neurol. Published online June 03, 2013. doi:10.1001/jamaneurol.2013.2977
Original Contribution | June 3, 2013 
Predictors of Hematoma Volume in Deep and Lobar Supratentorial Intracerebral Hemorrhage
Guido J. Falcone, MD, MPH; Alessandro Biffi, MD; H. Bart Brouwers, MD; Christopher D. Anderson, MD; Thomas W. K. Battey, BS; Alison M. Ayres, BA; Anastasia Vashkevich, BA; Kristin Schwab, BA; Natalia S. Rost, MD, MPH; Joshua N. Goldstein, MD, PhD; Anand Viswanathan, MD, PhD; Steven M. Greenberg, MD, PhD; Jonathan Rosand, MD, MSc
Includes: Supplemental Content
ImportanceImportance Hematoma volume is the strongest predictor of outcome in intracerebral hemorrhage (ICH). Despite known differences in the underlying biology between deep ...
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JAMA Neurol. Published online June 03, 2013. doi:10.1001/jamaneurol.2013.98
Original Contribution | May 27, 2013 
Cross-sectional and Longitudinal Analysis of the Relationship Between Aβ Deposition, Cortical Thickness, and Memory in Cognitively Unimpaired Individuals and in Alzheimer Disease
Vincent Doré, PhD; Victor L. Villemagne, MD; Pierrick Bourgeat, PhD; Jurgen Fripp, PhD; Oscar Acosta, PhD; Gael Chetélat, PhD; Luping Zhou, PhD; Ralph Martins, PhD; Kathryn A. Ellis, PhD; Colin L. Masters, MD; David Ames, MD; Oliver Salvado, PhD; Christopher C. Rowe, MD
Includes: Supplemental Content
ImportanceImportance β-amyloid (Aβ) deposition is one of the hallmarks of Alzheimer disease. Aβ deposition accelerates gray matter atrophy at early stages of ...
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JAMA Neurol. Published online May 27, 2013. doi:10.1001/jamaneurol.2013.1062
Images in Neurology | May 27, 2013 
Cortical Vein Air Emboli With Gyriform Infarcts
Daniel Lai, MD; Tudor G. Jovin, MD; Ashutosh P. Jadhav, MD, PhD
A 67-year-old man with stage III lung cancer complicated by lung abscesses was receiving fluid resuscitation for dehydration through a left subclavian ...
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JAMA Neurol. Published online May 27, 2013. doi:10.1001/jamaneurol.2013.1949
Images in Neurology | May 27, 2013 
Fulminant Idiopathic Intracranial Hypertension
Aasef G. Shaikh, MD, PhD; James H. Bates, MD; Scott W. Yeates, MD; Bashar Katirji, MD; Michael W. Devereaux, MD
Fulminant idiopathic intracranial hypertension is extremely rare but invariably is associated with permanent blindness unless there is prompt intervention. Hypothetically, a rapid ...
JAMA Neurol. Published online May 27, 2013. doi:10.1001/jamaneurol.2013.1951
Viewpoint | May 27, 2013 
Inpatient Neurologic Care:  Continued Challenges of a Neurohospitalist Model
S. Andrew Josephson, MD
Over the past 5 years, the neurohospitalist model of care has grown rapidly in both academic and community settings and appears poised ...
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JAMA Neurol. Published online May 27, 2013. doi:10.1001/jamaneurol.2013.2968
Clinical Pathologic Conference | May 27, 2013 
Blind and Confused
Vibhash D. Sharma, MD; Patrick Malafronte, MD; Nicole De Simone, MD; Benjamin M. Greenberg, MD, MHS
A 62-year-old man developed confusion and was diagnosed as having encephalitis. The etiology was not identified. He continued to have cognitive impairment ...
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JAMA Neurol. Published online May 27, 2013. doi:10.1001/jamaneurol.2013.3105

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