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 Showing 41-57 of 57 Articles
Original Investigation 
Giuseppe Tosto, MD, PhD; Thomas D. Bird, MD; David A. Bennett, MD; Bradley F. Boeve, MD; Adam M. Brickman, PhD; Carlos Cruchaga, PhD; Kelley Faber, MS; Tatiana M. Foroud, PhD; Martin Farlow, MD; Alison M. Goate, DPhil; Neill R. Graff-Radford, MD; Rafael Lantigua, MD; Jennifer Manly, PhD; Ruth Ottman, PhD; Roger Rosenberg, MD; Daniel J. Schaid, PhD; Nicole Schupf, PhD; Yaakov Stern, PhD; Robert A. Sweet, MD; Richard Mayeux, MD, MSc; for the National Institute on Aging Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) Family Study Group
Includes: Supplemental Content

Importance  The contribution of cardiovascular disease (CV) and cerebrovascular disease to the risk for late-onset Alzheimer disease (LOAD) has been long debated. Investigations have shown that antecedent CV risk factors increase the risk for LOAD, although other investigations have failed to validate this association.

Objective  To ...

Volker Behrendt, MD; Christos Krogias, MD; Anke Reinacher-Schick, MD; Ralf Gold, MD; Ingo Kleiter, MD

This case series describes 2 women with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis whose disease remitted with bortezomib treatment.

Comment & Response 
Georgios Tsivgoulis, MD; Aristeidis H. Katsanos, MD; Andrei V. Alexandrov, MD

In Reply We thank Charidimou for reading our recently published article1 in JAMA Neurology on the risk for symptomatic intracerebral hemorrhage after intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) and high cerebral microbleed (CMB) burden on pre-IVT magnetic resonance imaging (MRI) screening,1 and ...

Comment & Response 
Andreas Charidimou, MD, MSc (Clinical Neurology), PhD

To the Editor I read with interest the article by Tsivgoulis et al1 in JAMA Neurology on cerebral microbleeds (CMBs) and the risk for symptomatic intracerebral hemorrhage (ICH) after intravenous thrombolysis for acute stroke, as well as the accompanying Editorial by Fisher.2 This work follows and ...

Joseph F. Quinn, MD

Numerous epidemiologic studies suggest that dietary consumption of fish or of ω-3 fatty acids (the putative “active ingredient” in fish) may reduce the risk of late-life dementia including Alzheimer disease (AD). However, clinical trials have failed to demonstrate disease-modifying effects in mild to moderate AD,1,2...

Original Investigation 
Reinier C. van Houwelingen, MD; Gert-Jan Luijckx, MD, PhD; Aryan Mazuri, MD; Reinoud P. H. Bokkers, MD, PhD; Omid S. Eshghi, MD; Maarten Uyttenboogaart, MD, PhD
Includes: Supplemental Content

Importance  After the many positive results in thrombectomy trials in ischemic stroke of the anterior circulation, the question arises whether these positive results also apply to the patient with basilar artery occlusion (BAO).

Objective  To report up-to-date outcome data of intra-arterial (IA) treatment in patients with ...

Original Investigation 
Hussein N. Yassine, MD; Qingru Feng, MSc; Ida Azizkhanian, MSc; Varun Rawat, PhD; Katherine Castor, PhD; Alfred N. Fonteh, PhD; Michael G. Harrington, MB, ChB; Ling Zheng, PhD; Bruce R. Reed, PhD; Charles DeCarli, MD; William J. Jagust, MD; Helena C. Chui, MD

Importance  Higher dietary intake of the essential fatty acid docosahexaenoic (DHA) has been associated with better cognitive performance in several epidemiological studies. Animal and in vitro studies also indicate that DHA prevents amyloid deposition in the brain.

Objective  To determine the association between serum DHA levels, ...

Editorial: Do ω-3 Fatty Acids Regulate Cerebral β Amyloid?; Joseph F. Quinn, MD
Images in Neurology 
Antonio Cruz-Culebras, MD; Rocío Vera, MD, PhD; Juan Martinez San Millan, MD

This case report describes the clinical and imaging features of a man in his 60s who had occlusion of a single pericallosal artery causing

bilateral corpus callosum infarction.

Comment & Response 
Qinghua Jiang, PhD; Yang Hu, PhD; Guiyou Liu, PhD

To the Editor We read with interest the study from Yokoyama et al.1 In this study, Yokoyama et al1 investigated the genetic overlap between Alzheimer disease and immune-mediated diseases including Crohn disease, ulcerative colitis, rheumatoid arthritis, type 1 diabetes, celiac disease, and psoriasis using 7 genome-wide ...

Comment & Response 
Jennifer S. Yokoyama, PhD; Rahul S. Desikan, MD, PhD

In Reply We appreciate the interest of Jiang et al and the research community in our work examining genetic overlap between Alzheimer disease (AD) and autoimmune disease. As we noted in our article,1 given the extensive linkage disequilibrium structure of regions, such as the HLA on chromosome ...

Lyell K. Jones Jr, MD

This Viewpoint discusses how the US health care system will transition from volume-based to value-based payment and care under the Medicare Access and Children’s Health Insurance Program Reauthorization Act of 2015.

Jill Sergesketter Butler, PhD; Marek Napierala, PhD

The use of short, synthetic nucleic acids as potential therapeutics was proposed more than 3 decades ago. However, improvements in the design and synthesis of nucleic acids have recently piqued the interest of researchers and physicians searching for alternative approaches for treating diseases that do not conform to ...

Clinical Implications of Basic Neuroscience Research 
David R. Corey, PhD

Importance  The ability to control gene expression with antisense oligonucleotides (ASOs) could provide a new treatment strategy for disease.

Objective  To review the use of ASOs for the treatment of neurological disorders.

Evidence Review  Articles were identified through a search of PubMed references from 2000 ...

Editorial: Therapeutic Potential of Synthetic Nucleic Acids for Neurological Diseases; Jill Sergesketter Butler, PhD; Marek Napierala, PhD
JAMA Neurology Clinical Challenge 
Zubeda Sheikh, MD; Weizhen Wang, MD; Machteld Hillen, MD

A man in his 30s presented with a 5-day history of vomiting, followed by lethargy and confusion. Two years prior, he had been hospitalized with coma with no identifiable precipitant. What is your diagnosis?

Comment & Response 
Mika H. Martikainen, MD, PhD; David J. Burn, PhD, FRCP; Doug M. Turnbull, PhD, FRCP

In Reply Finsterer and Zarrouk-Mahjoub list movement disorders not mentioned in our article1; however, we would question their relevance. The article they referenced by Gimelli et al2 reports 4 cases of inherited Tourette syndrome. Although the protein localizes to mitochondria, no evidence of mitochondrial dysfunction ...

Comment & Response 
Josef Finsterer, MD, PhD; Sinda Zarrouk-Mahjoub, PhD

To the Editor With interest we read the article by Martikainen et al1 about 42 genetically or biochemically confirmed adult (n = 30) and pediatric (n = 12) patients with a mitochondrial disorder (MID) who also presented with various types of an extrapyramidal movement disorder. We have the following comments and ...

Correction  FREE

In the Original Investigation article by Santos-Santos et al titled “Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration,” published online April 25, 2016, and also in the June 2016 print issue of JAMA Neurology,1 there was an ...

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