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 Showing 41-48 of 48 Articles
Original Investigation 
Crandall E. Peeler, MD; Lindsey B. De Lott, MD; Lina Nagia, DO; Joao Lemos, MD; Eric R. Eggenberger, DO, MSEpi; Wayne T. Cornblath, MD

Importance  The sensitivity of acetylcholine receptor (AChR) antibody testing is thought to be lower in ocular myasthenia gravis (OMG) compared with generalized disease, although estimates in small-scale studies vary. There is little information in the literature about the implications of AChR antibody levels and progression from OMG ...

Original Investigation 
David C. Bäckström, MD; Magdalena Eriksson Domellöf, PhD; Jan Linder, MD, PhD; Bob Olsson, PhD; Annika Öhrfelt, PhD; Miles Trupp, PhD; Henrik Zetterberg, MD, PhD; Kaj Blennow, MD, PhD; Lars Forsgren, MD, PhD
Includes: Supplemental Content

Importance  Alterations in cerebrospinal fluid (CSF) have been found in Parkinson disease (PD) and in PD dementia (PDD), but the prognostic importance of such changes is not well known. In vivo biomarkers for disease processes in PD are important for future development of disease-modifying therapies.

Objective  ...

Original Investigation 
Matthew Schrag, MD; Teddy Youn, MD; Joseph Schindler, MD; Howard Kirshner, MD; David Greer, MD

Importance  Central retinal artery occlusion (CRAO) is an ophthalmologic emergency that can result in blindness. At present, no proven therapy for CRAO exists. Treatment with fibrinolytic agents has shown promise but remains of unproven benefit.

Objectives  To assess the efficacy of systemic fibrinolytic therapy for patients ...

Images in Neurology 
José Rafael P. Zuzuárregui, MD; Samuel A. Frank, MD

This case report describes ataxia with uncontrollable palatal tremor in an elderly man.

Mark J. Alberts, MD; Ty Shang, MD, PhD; Alejandro Magadan, MD

Patients with an occlusion of the distal internal carotid or proximal middle cerebral artery have among the most severe types of ischemic stroke that typically produce life-altering disabilities. Prior to a few months ago, the standard of care for such patients included intravenous (IV) alteplase and comprehensive peristroke ...

Elaine R. Peskind, MD; Brian Kraemer, PhD; Jing Zhang, MD, PhD

The search for plasma biomarkers of mild traumatic brain injury (mTBI) remains intense. The US Department of Defense and US Department of Veterans Affairs have invested more than $100 million toward this effort and the General Electric National Football League Challenge award made to Quanterix and Banyan Biomarkers ...

Original Investigation 
Anlys Olivera, PhD; Natasha Lejbman, BS; Andreas Jeromin, PhD; Louis M. French, PsyD; Hyung-Suk Kim, PhD; Ann Cashion, PhD; Vincent Mysliwiec, MD; Ramon Diaz-Arrastia, MD, PhD; Jessica Gill, RN, PhD

Importance  Approximately one-third of military personnel who deploy for combat operations sustain 1 or more traumatic brain injuries (TBIs), which increases the risk for chronic symptoms of postconcussive disorder, posttraumatic stress disorder, and depression and for the development of chronic traumatic encephalopathy. Elevated concentrations of tau are ...

Editorial: Biofluid Biomarkers of Mild Traumatic Brain Injury; Elaine R. Peskind, MD; Brian Kraemer, PhD; Jing Zhang, MD, PhD
Clinical Implications of Basic Neuroscience Research 
Joseph M. Castellano, PhD; Elizabeth D. Kirby, PhD; Tony Wyss-Coray, PhD

In the modern medical era, more diverse and effective treatment options have translated to increased life expectancy. With this increased life span comes increased age-associated disease and the dire need to understand underlying causes so that therapies can be designed to mitigate the burden to health and the ...

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