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 Showing 21-34 of 34 Articles
Original Investigation 
Maxwell Greene, MD; Yongjie Lai, MD; Nicolle Baella; Josep Dalmau, MD, PhD; Eric Lancaster, MD, PhD

Importance  The anti-Tr immune response is associated with paraneoplastic cerebellar degeneration and Hodgkin lymphoma (HL). One case series has reported that the Delta/notch-like epidermal growth factor–related receptor (DNER) is the actual target for anti-Tr antibodies, but this result has not been replicated.

Objective  To describe a ...

Original Investigation 
Helena Ariño, MD; Nuria Gresa-Arribas, PhD; Yolanda Blanco, MD, PhD; Eugenia Martínez-Hernández, MD, PhD; Lidia Sabater, PhD; Mar Petit-Pedrol, BS; Idoia Rouco, MD; Luis Bataller, MD; Josep O. Dalmau, MD, PhD; Albert Saiz, MD, PhD; Francesc Graus, MD, PhD
Includes: Supplemental Content

Importance  Current clinical and immunologic knowledge on cerebellar ataxia (CA) with glutamic acid decarboxylase 65 antibodies (GAD65-Abs) is based on case reports and small series with short-term follow-up data.

Objective  To report the symptoms, additional antibodies, prognostic factors, and long-term outcomes in a cohort of patients ...

Original Investigation 
Christine L. Mac Donald, PhD; Ann M. Johnson; Linda Wierzechowski, RN; Elizabeth Kassner, RN; Theresa Stewart, RN; Elliot C. Nelson, MD; Nicole J. Werner, PhD; David Zonies, MD, MPH; John Oh, MD; Raymond Fang, MD; David L. Brody, MD, PhD

Importance  Blast injury has been identified as the signature injury in the conflicts in Iraq and Afghanistan. However it remains to be determined whether fundamental differences may exist between blast-related traumatic brain injury (TBI) and TBI due to other mechanisms.

Objectives  To determine similarities and differences ...

Case Report/Case Series 
Yong Guo, MD, PhD; Vanda A. Lennon, MD, PhD; Bogdan F. Gh. Popescu, MD, PhD; Carrie Katherine Grouse, MD; Jordan Topel, MD; Margherita Milone, MD, PhD; Hans Lassmann, MD; Joseph E. Parisi, MD; Sean J. Pittock, MD; Dusan Stefoski, MD; Roumen Balabanov, MD; Claudia F. Lucchinetti, MD

Importance  Documentation of muscle pathology compatible with targeting of sarcolemmal aquaporin-4 (AQP4) by complement-activating IgG implies involvement of organs beyond the central nervous system in neuromyelitis optica spectrum disorders.

Observations  We report on a 51-year-old woman who had relapsing optic neuritis, transverse myelitis, AQP4-IgG seropositivity, and ...

Images in Neurology 
Seong-il Oh, MD; Seung Hyun Kim, MD; Hee-Jin Kim, MD
A 46-year-old woman developed dysarthria for 2 weeks. She also manifested headaches for several years. Her blood pressure was 140/99 mm Hg. The results of a neurologic examination showed right hemiparesis with a power grade of 3/5 in the right upper limb and lower limb, but her cognitive function and ...
Original Investigation 
Jay M. Margolis, PharmD; Bong-Chul Chu, PhD; Zhixiao J. Wang, PhD; Ronda Copher, PhD; Jose E. Cavazos, MD, PhD

Importance  To our knowledge, the current study is the first to describe antiepileptic drug (AED) combination therapy patterns according to their mechanism of action (MOA) in a real-world setting and to evaluate the differences in outcomes comparing different-MOA combination therapy with same-MOA combination therapy for patients with ...

Multiple sclerosis (MS) is an autoimmune demyelinating disease characterized by a complex mix of genetics and gene-environment interactions. As compared with white Americans, African Americans are thought to have a lower risk for developing MS but a greater risk of disability and more opticospinal MS. Data show that MS in ...
The chief difference between a primary prevention trial and a secondary prevention trial (SPT) in Alzheimer disease (AD) is related to the targeted group of participants. As currently conceptualized, a primary prevention trial recruits asymptomatic individuals from the general population, whereas an SPT recruits only asymptomatic (or preclinical) individuals who ...
Original Investigation 
Michael C. Donohue, PhD; Reisa A. Sperling, MD; David P. Salmon, PhD; Dorene M. Rentz, PsyD; Rema Raman, PhD; Ronald G. Thomas, PhD; Michael Weiner, MD; Paul S. Aisen, MD; for the Australian Imaging, Biomarkers, and Lifestyle Flagship Study of Ageing; the Alzheimer’s Disease Neuroimaging Initiative; and the Alzheimer’s Disease Cooperative Study
Includes: Supplemental Content

Importance  As Alzheimer disease (AD) research moves to intervene in presymptomatic phases of the disease, we must develop outcome measures sensitive to the earliest disease-related changes.

Objective  To demonstrate the feasibility of a cognitive composite outcome for clinically normal elderly participants with evidence of AD pathology ...

Original Investigation 
Christian Dehlendorff, MS, PhD; Klaus K. Andersen, MS, PhD; Tom S. Olsen, MD, PhD

Importance  Reports of an obesity paradox have led to uncertainty about secondary prevention in obese patients with stroke. The paradox is disputed and has been claimed to be an artifact due to selection bias.

Objective  To determine whether the obesity paradox in stroke is real or ...

Original Investigation 
Sharon Ooms, MSc; Sebastiaan Overeem, MD; Kees Besse, MD; Marcel Olde Rikkert, MD, PhD; Marcel Verbeek, MSc, PhD; Jurgen A. H. R. Claassen, MD, PhD

Importance  Increasing evidence suggests a relationship between poor sleep and the risk of developing Alzheimer disease. A previous study found an effect of sleep on β-amyloid (Aβ), which is a key protein in Alzheimer disease pathology.

Objective  To determine the effect of 1 night of total ...

In this issue of Archives, McKeon et al1 report that 10 of 81 patients with stiff-man syndrome from the Mayo Clinic in Rochester, Minnesota, had serum and/or cerebrospinal fluid IgG antibodies that bound to fixed, permeabilized HEK293 cells (an immortalized human kidney line) that had been transfected to express the ...
Topics: autoantibodies
Original Contribution  FREE
Ross W. Paterson, MRCP; Charles C. Torres-Chae, MPA; Amy L. Kuo, MS, RN, GNP; Tim Ando, BA; Elizabeth A. Nguyen, BS; Katherine Wong, BS; Stephen J. DeArmond, MD, PhD; Aissa Haman, MD; Paul Garcia, MD; David Y. Johnson; Bruce L. Miller, MD; Michael D. Geschwind, MD, PhD

Objectives To identify the misdiagnoses of patients with sporadic Jakob-Creutzfeldt disease (sCJD) during the course of their disease and determine which medical specialties saw patients with sCJD prior to the correct diagnosis being made and at what point in the disease course a correct diagnosis was made.

Design...

Original Contribution  FREE
Yafei Huang, PhD; Rachel Potter, BA; Wendy Sigurdson, MSN; Tom Kasten, PhD; Rose Connors, BA; John C. Morris, MD; Tammie Benzinger, MD; Mark Mintun, MD; Tim Ashwood, PhD; Mats Ferm, PhD; Samantha L. Budd, PhD; Randall J. Bateman, MD
Includes: Supplemental Content

Objectives To investigate dynamic changes in human plasma β-amyloid (Aβ) concentrations, evaluate the effects of aging and amyloidosis on these dynamics, and determine their correlation with cerebrospinal fluid (CSF) Aβ concentrations.

Design A repeated plasma and CSF sampling study.

Setting The Washington University School of Medicine in St ...

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