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Basic View | Expanded View
 Showing 21-37 of 37 Articles
Original Investigation 
Andrés E. Monserrate, BS; Davis C. Ryman, MD, PhD; Shengmei Ma, MS; Chengjie Xiong, PhD; James M. Noble, MD, MS, CPH; John M. Ringman, MD, MS; John C. Morris, MD; Adrian Danek, MD; Felix Müller-Sarnowski, MD; David B. Clifford, MD; Eric M. McDade, DO; William S. Brooks, MBBS; David G. Darby, PhD; Colin L. Masters, MD; Philip S. J. Weston, MD; Martin R. Farlow, MD; Neill R. Graff-Radford, MD; Stephen P. Salloway, MD, MS; Anne M. Fagan, PhD; Angela Oliver, RN; Randall J. Bateman, MD; for the Dominantly Inherited Alzheimer Network

Importance  This study assesses factors associated with the most common adverse event following lumbar puncture.

Objective  To identify factors associated with the risk, onset, and persistence of post–dural puncture headache (PDPH).

Design, Setting, and Participants  We performed univariate and multivariable analyses of 338 lumbar punctures ...

Original Investigation 
Craig Curtis, MD; Jose E. Gamez, MD; Upinder Singh, MD; Carl H. Sadowsky, MD; Teresa Villena, MD; Marwan N. Sabbagh, MD; Thomas G. Beach, MD, PhD; Ranjan Duara, MD; Adam S. Fleisher, MD, MAS; Kirk A. Frey, MD, PhD; Zuzana Walker, MD; Arvinder Hunjan, MRCPysch; Clive Holmes, MRCPsych, PhD; Yavir M. Escovar, MD; Carla X. Vera, CCRC; Marc E. Agronin, MD; Joel Ross, MD, CMD, CPI; Andrea Bozoki, MD; Mary Akinola, MB, BS; Jiong Shi, MD, PhD; Rik Vandenberghe, MD, PhD; Milos D. Ikonomovic, MD; Paul F. Sherwin, MD, PhD; Igor D. Grachev, MD, PhD; Gillian Farrar, PhD; Adrian P. L. Smith, BSc, PhD; Christopher J. Buckley, BSc, PhD; Richard McLain, MS; Stephen Salloway, MD, MS
Includes: Supplemental Content

Importance  In vivo imaging of brain β-amyloid, a hallmark of Alzheimer disease, may assist in the clinical assessment of suspected Alzheimer disease.

Objective  To determine the sensitivity and specificity of positron emission tomography imaging with flutemetamol injection labeled with radioactive fluorine 18 to detect β-amyloid in ...

Editorial: Translational Journey of Amyloid Imaging; Gil D. Rabinovici, MD
Clinical Pathologic Conference 
Mark R. Etherton, MD, PhD; Martha R. Neagu, MD, PhD; Derek H. Oakley, MD; Matthew J. Koch, MD; John H. Shin, MD; Matthew P. Frosch, MD, PhD; Aaron L. Berkowitz, MD, PhD; Jorg Dietrich, MD, PhD

A 20-year-old man presented with 1 week of low back pain and progressive lower extremity weakness. Results of cerebrospinal fluid analysis demonstrated elevated total protein and a mildly elevated white blood cell count with lymphocytic predominance. Findings from imaging studies revealed a multifocal, heterogeneously enhancing, intramedullary lesion involving ...

Original Investigation 
Pengcheng Han, MD, PhD; Richard J. Caselli, MD; Leslie Baxter, PhD; Geidy Serrano, PhD; Junxiang Yin, MD, PhD; Thomas G. Beach, MD, PhD; Eric M. Reiman, MD; Jiong Shi, MD, PhD

Importance  There is a deficit of pituitary adenylate cyclase–activating polypeptide (PACAP) in patients with neuropathologically confirmed Alzheimer dementia. However, whether this deficit is associated with the earlier stages of Alzheimer disease (AD) is unknown. This study was conducted to clarify the association between PACAP biomarkers and preclinical, ...

Original Investigation 
Jose Gutierrez, MD, MPH; Randolph S. Marshall, MD, MS; Ronald M. Lazar, PhD

Importance  Whether cognition is influenced by arterial stiffness in the absence of vascular disease remains uncertain.

Objective  To test the hypotheses that indirect measures of arterial stiffness are important predictors of cognitive performance and that this relationship varies depending on the presence of vascular disease.

Design, ...

Original Investigation 
Allison R. Kaup, PhD; Jasmine Nettiksimmons, PhD; Tamara B. Harris, MD; Kaycee M. Sink, MD, MAS; Suzanne Satterfield, MD, DrPH; Andrea L. Metti, PhD; Hilsa N. Ayonayon, PhD; Kristine Yaffe, MD; for the Health, Aging, and Body Composition (Health ABC) Study
Includes: Supplemental Content

Importance  Apolipoprotein E (APOE) ε4 is an established risk factor for cognitive decline and the development of dementia, but other factors may help to minimize its effects.

Objective  Using APOE ε4 as an indicator of high risk, we investigated factors associated with cognitive resilience ...

Clinical Implications of Basic Neuroscience Research 
Kara N. Corps, DVM, DACVP; Theodore L. Roth, MS; Dorian B. McGavern, PhD

Importance  Traumatic brain injury (TBI) is a significant public health concern that affects individuals in all demographics. With increasing interest in the medical and public communities, understanding the inflammatory mechanisms that drive the pathologic and consequent cognitive outcomes can inform future research and clinical decisions for patients ...

Mark J. Alberts, MD
In this issue of JAMA Neurology, Jalbert and colleagues1 present the results of a detailed analysis of Centers for Medicare & Medicaid Services (CMS) administrative data on patients with carotid artery stenosis treated with carotid artery stenting. Their well-written manuscript and timely study included more than 22 000 patients treated ...
Original Investigation 
Adam S. Fleisher, MD; Kewei Chen, PhD; Yakeel T. Quiroz, PhD; Laura J. Jakimovich, RN, MS; Madelyn Gutierrez Gomez, BA; Carolyn M. Langois, BA; Jessica B. S. Langbaum, PhD; Auttawut Roontiva, MS; Pradeep Thiyyagura, MS; Wendy Lee, MS; Napatkamon Ayutyanont, PhD; Liliana Lopez, BA; Sonia Moreno, MS; Claudia Muñoz, BA; Victoria Tirado, MS; Natalia Acosta-Baena, MD; Anne M. Fagan, PhD; Margarita Giraldo, MD; Gloria Garcia, MS; Matthew J. Huentelman, PhD; Pierre N. Tariot, MD; Francisco Lopera, MD; Eric M. Reiman, MD

Importance  Age-associated changes in brain imaging and fluid biomarkers are characterized and compared in presenilin 1 (PSEN1)E280A mutation carriers and noncarriers from the world’s largest known autosomal dominant Alzheimer disease (AD) kindred.

Objective  To characterize and compare age-associated changes in brain imaging and fluid ...

Original Investigation 
Jessica J. Jalbert, PhD; Louis L. Nguyen, MD, MBA, MPH; Marie D. Gerhard-Herman, MD; Michael R. Jaff, DO; Christopher J. White, MD; Andrew T. Rothman, MSc; John D. Seeger, PharmD, DrPH; Hiraku Kumamaru, MD, MPH; Lauren A. Williams, BA; Chih-Ying Chen, PhD; Jun Liu, MD, MPH; Thomas T. Tsai, MD, MSc; Herbert D. Aronow, MD, MPH; Joseph A. Johnston, MD, MSc; Thomas G. Brott, MD; Soko Setoguchi, MD, DrPH
Includes: Supplemental Content

Importance  Despite increased carotid artery stenting (CAS) dissemination following the 2005 National Coverage Determination, to our knowledge, periprocedural and long-term outcomes have not been described among Medicare beneficiaries.

Objective  To describe the incidence of outcomes during and after the periprocedural period among Medicare beneficiaries undergoing CAS....

Editorial: Carotid Stenting; Mark J. Alberts, MD
Original Investigation 
Jae-Sung Lim, MD, MSc; Keun-Sik Hong, MD, PhD; Gyeong-Moon Kim, MD, PhD; Oh Young Bang, MD, PhD; Hee-Joon Bae, MD, PhD; Hyung-Min Kwon, MD, PhD; Jong-Moo Park, MD, PhD; Seung-Hoon Lee, MD, PhD; Joung-Ho Rha, MD, PhD; Jaseong Koo, MD, PhD; Kyung-Ho Yu, MD, PhD; Woo-Keun Seo, MD, PhD; Kyung Bok Lee, MD, PhD; Yong-Seok Lee, MD, PhD
Includes: Supplemental Content

Importance  The risk of early recurrent stroke after transient ischemic attack (TIA) may be modifiable by optimal treatment. Although ABCD2 scores, diffusion-weighted imaging lesions, and large artery stenosis are well known to predict early stroke recurrence, other neuroimaging parameters, such as cerebral microbleeds (CMBs), have not ...

Lawrence R. Wechsler, MD

Importance  The growing disparity between the demand for neurological services and the need for neurologists requires new and innovative strategies for delivering care. Teleneurology allows neurological expertise to be delivered to remote locations to supplement or replace in-person neurological care.

Objective  To summarize the current status ...

Maxime W. C. Rousseaux, PhD; Huda Y. Zoghbi, MD
The viewpoint reports on the 2014 Lasker-DeBakey Clinical Medical Research Award honoring Mahlon R. DeLong, MD, and Alim-Louis Benabid, MD, PhD, for their development of deep brain stimulation of the subthalamic nucleus for patients with advanced Parkinson disease.
Brad E. Pfeiffer, PhD; David J. Foster, PhD
This Viewpoint reports on 3 neuroscientists who were recently awarded the 2014 Nobel Prize in Physiology or Medicine for their seminal research in understanding how 2 neighboring brain regions, the hippocampus and the entorhinal cortex, represent spatial information.
Several human degenerative diseases appear as a result of the misfolding and aggregation of proteins.1 The prototype central nervous system proteinopathy is Creutzfeldt-Jakob disease (CJD), in which neuronal prion protein (PrP) with high α-helical content switches into a stable structure rich in β-pleated sheets in a self-catalyzing process that eventually, ...
Original Investigation 
Madeleine Liljegren, MD; Georges Naasan, MD; Julia Temlett, MBBS; David C. Perry, MD; Katherine P. Rankin, PhD; Jennifer Merrilees, PhD; Lea T. Grinberg, MD, PhD; William W. Seeley, MD; Elisabet Englund, MD; Bruce L Miller, MD
Includes: Supplemental Content

Importance  Neurodegenerative diseases can cause dysfunction of neural structures involved in judgment, executive function, emotional processing, sexual behavior, violence, and self-awareness. Such dysfunctions can lead to antisocial and criminal behavior that appears for the first time in the adult or middle-aged individual or even later in life....

Original Investigation 
Aline Dorey, PhD; Yannick Tholance, MSc, PharmD; Alain Vighetto, MD; Armand Perret-Liaudet, PharmD; Ingolf Lachman, PhD; Pierre Krolak-Salmon, MD, PhD; Uta Wagner, PhD; Hanne Struyfs, MSc; Peter P. De Deyn, MD, PhD; Benaissa El-Moualij, PhD; Willy Zorzi, PhD; David Meyronet, MD, PhD; Nathalie Streichenberger, MD; Sebastiaan Engelborghs, MD, PhD; Gabor G. Kovacs, MD, PhD; Isabelle Quadrio, PharmD, PhD
Includes: Supplemental Content

Importance  Although typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atypical AD phenotypes may pose a diagnostic challenge. The major biological diagnostic biomarker for identifying CJD, 14-3-3 protein in cerebrospinal fluid (CSF), unfortunately lacks specificity when confronting a rapid dementia presentation.


Editorial: Cerebrospinal Fluid Total Prion Protein; Henrik Zetterberg, MD, PhD

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