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 Showing 21-34 of 34 Articles
Ivan Rocha Ferreira Da Silva, MD; Jennifer A. Frontera, MD

Importance  The disparity between patients awaiting organ transplantation and organ availability increases each year. As a consequence, organ trafficking has emerged and developed into a multibillion-dollar-a-year industry.

Objective  To identify and address barriers to organ donation in the United States and globally.

Evidence Review  Evidence-based ...

Original Investigation 
Eoin P. Flanagan, MBBCh; Brian G. Weinshenker, MD; Karl N. Krecke, MD; Vanda A. Lennon, MD, PhD; Claudia F. Lucchinetti, MD; Andrew McKeon, MBBCh; Dean M. Wingerchuk, MD; Elizabeth A. Shuster, MD; Yujuan Jiao, MD; Erika S. Horta, MD; Sean J. Pittock, MD

Importance  Short transverse myelitis (STM; <3 vertebral segments) is considered noncharacteristic of neuromyelitis optica (NMO) spectrum disorders (NMOSDs). Nonappreciation of the potential for STM to occur in NMOSD may lead to increased disability from delay in diagnosis and appropriate treatment.

Objectives  To determine the frequency of ...

Original Investigation 
Nimeshan Geevasinga, MBBS; Parvathi Menon, MBBS; James Howells, PhD; Garth A. Nicholson, PhD; Matthew C. Kiernan, DSc; Steve Vucic, PhD

Importance  Abnormalities of axonal excitability characterized by upregulation of persistent sodium (Na+) conductances and reduced potassium (K+) currents have been reported in sporadic amyotrophic lateral sclerosis (SALS) phenotypes and linked to the development of clinical features such as fasciculations and neurodegeneration.

Objective  ...

Original Investigation 
Enyinna L. Nwachuku, BS; Jeffrey R. Balzer, PhD; Jonathan G. Yabes, PhD; Miguel E. Habeych, MD, MPH; Donald J. Crammond, PhD; Parthasarathy D. Thirumala, MD, MS
Includes: Supplemental Content

Importance  Perioperative stroke is a persistent complication of carotid endarterectomy (CEA) for patients with symptomatic carotid stenosis (CS).

Objective  To evaluate whether changes in somatosensory evoked potential (SSEP) during CEA are diagnostic of perioperative stroke in patients with symptomatic CS.

Design, Setting, and Participants  We ...

Original Investigation 
Feng-Cheng Lin, MD; Ching-Piao Tsai, MD; Johnny Kuang-Wu Lee, PhD; Ming-Tsang Wu, MD, DSc; Charles Tzu-Chi Lee, PhD

Importance  Although several studies have shown that use of angiotensin-converting enzyme inhibitors (ACEIs) potentially decreased amyotrophic lateral sclerosis (ALS) risk in animal models, to our knowledge, there has been no human study in the literature discussing this issue.

Objective  To investigate the association between the use ...

Case Report/Case Series 
Robert Fleischmann, MD; Harald Prüss, MD; Berit Rosche, MD; Markus Bahnemann, MD; Harald Gelderblom, MD; Katrin Deuschle, MD; Lutz Harms, MD; Ute Kopp, MD; Klemens Ruprecht, MD
Includes: Supplemental Content

Importance  Some patients with multiple sclerosis (MS) can either present with or develop severe cognitive impairment during the course of their disease. However, the mechanisms underlying severe cognitive dysfunction in MS are not well understood.

Observations  We report on a woman who was diagnosed as having ...

Takayuki Itoh, MD, PhD; David Pleasure, MD
This viewpoint focuses on the technological advances in nucleotide sequencing and genetic engineering and on our deepening understanding of the molecular processes underlying Schwann cell–axon interactions and axonal degeneration.
Bryan J. Traynor, MD, PhD; Alan E. Renton, PhD
Genome-wide association studies have been tremendously successful at unraveling the genetic architecture of neurological disorders (see http://www.genome.gov/gwastudies/ for an updated list). Alzheimer disease is a particularly good example of the power of this technology, with multiple loci already identified.1 Although the publication of a susceptibility locus is an important milestone ...
Original Investigation 
Jeffrey M. Gelfand, MD, MAS; Gillian Genrich, MD, MPH; Ari J. Green, MD, MAS; Tarik Tihan, MD, PhD; Bruce A. C. Cree, MD, PhD, MAS

Importance  Brain biopsy specimens that exhibit encephalitis without specific histopathologic features pose a diagnostic challenge to neuropathologists and neurologists. Such cases are generally referred to pathologically as encephalitis, not otherwise specified (ENOS). A systematic approach to diagnostic evaluation in such patients is challenging, and currently there is ...

Original Investigation 
Lei Yu, PhD; Lori B. Chibnik, PhD; Gyan P. Srivastava, PhD; Nathalie Pochet, PhD; Jingyun Yang, PhD; Jishu Xu, MS; James Kozubek, MS; Nikolaus Obholzer, PhD; Sue E. Leurgans, PhD; Julie A. Schneider, MD; Alexander Meissner, PhD; Philip L. De Jager, MD, PhD; David A. Bennett, MD
Includes: Supplemental Content

Importance  Recent large-scale genome-wide association studies have discovered several genetic variants associated with Alzheimer disease (AD); however, the extent to which DNA methylation in these AD loci contributes to the disease susceptibility remains unknown.

Objective  To examine the association of brain DNA methylation in 28 reported ...

Clinical Implications of Basic Neuroscience Research 
Netanel Korin, PhD; Matthew J. Gounis, PhD; Ajay K. Wakhloo, MD, PhD; Donald E. Ingber, MD, PhD

Obstruction of normal blood flow, which occurs in a variety of diseases, including thromboembolism in stroke and atherosclerosis, is a leading cause of death and long-term adult disability in the Western world. This review focuses on a novel nanotherapeutic drug-delivery platform that is mechanically activated within blood vessels ...

In this issue of Archives, McKeon et al1 report that 10 of 81 patients with stiff-man syndrome from the Mayo Clinic in Rochester, Minnesota, had serum and/or cerebrospinal fluid IgG antibodies that bound to fixed, permeabilized HEK293 cells (an immortalized human kidney line) that had been transfected to express the ...
Topics: autoantibodies
Original Contribution  FREE
Ross W. Paterson, MRCP; Charles C. Torres-Chae, MPA; Amy L. Kuo, MS, RN, GNP; Tim Ando, BA; Elizabeth A. Nguyen, BS; Katherine Wong, BS; Stephen J. DeArmond, MD, PhD; Aissa Haman, MD; Paul Garcia, MD; David Y. Johnson; Bruce L. Miller, MD; Michael D. Geschwind, MD, PhD

Objectives To identify the misdiagnoses of patients with sporadic Jakob-Creutzfeldt disease (sCJD) during the course of their disease and determine which medical specialties saw patients with sCJD prior to the correct diagnosis being made and at what point in the disease course a correct diagnosis was made.


Original Contribution  FREE
Yafei Huang, PhD; Rachel Potter, BA; Wendy Sigurdson, MSN; Tom Kasten, PhD; Rose Connors, BA; John C. Morris, MD; Tammie Benzinger, MD; Mark Mintun, MD; Tim Ashwood, PhD; Mats Ferm, PhD; Samantha L. Budd, PhD; Randall J. Bateman, MD
Includes: Supplemental Content

Objectives To investigate dynamic changes in human plasma β-amyloid (Aβ) concentrations, evaluate the effects of aging and amyloidosis on these dynamics, and determine their correlation with cerebrospinal fluid (CSF) Aβ concentrations.

Design A repeated plasma and CSF sampling study.

Setting The Washington University School of Medicine in St ...

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