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 Showing 21-40 of 40 Articles
Original Investigation 
Michela Ripolone, PhD; Dario Ronchi, PhD; Raffaella Violano, BS; Dionis Vallejo, MD; Gigliola Fagiolari, BS; Emanuele Barca, MD; Valeria Lucchini, PhD; Irene Colombo, MD; Luisa Villa, MD; Angela Berardinelli, MD; Umberto Balottin, MD; Lucia Morandi, MD; Marina Mora, BS; Andreina Bordoni, BS; Francesco Fortunato, BS; Stefania Corti, PhD; Daniela Parisi, BS; Antonio Toscano, MD; Monica Sciacco, PhD; Salvatore DiMauro, MD; Giacomo P. Comi, MD; Maurizio Moggio, MD
Includes: Supplemental Content

Importance  The important depletion of mitochondrial DNA (mtDNA) and the general depression of mitochondrial respiratory chain complex levels (including complex II) have been confirmed, implying an increasing paucity of mitochondria in the muscle from patients with types I, II, and III spinal muscular atrophy (SMA-I, -II, and ...

Original Investigation 
Daniel A. Nation, PhD; Emily C. Edmonds, PhD; Katherine J. Bangen, PhD; Lisa Delano-Wood, PhD; Blake K. Scanlon, PhD; S. Duke Han, PhD; Steven D. Edland, PhD; David P. Salmon, PhD; Douglas R. Galasko, MD; Mark W. Bondi, PhD; for the Alzheimer’s Disease Neuroimaging Initiative Investigators
Includes: Supplemental Content

Importance  Increased pulse pressure associated with age-related arterial stiffening increases risk for Alzheimer dementia but the mechanism responsible for this association remains unclear.

Objectives  To determine the relationship between pulse pressure and cerebral spinal fluid biomarker profiles of preclinical Alzheimer disease, investigate whether observed relationships are ...

Original Investigation 
Jon B. Toledo, MD; Maria Bjerke, PhD; Xiao Da, MS; Susan M. Landau, PhD; Norman L Foster, MD; William Jagust, MD; Clifford Jack Jr, MD; Michael Weiner, MD; Christos Davatzikos, PhD; Leslie M. Shaw, PhD; John Q. Trojanowski, MD, PhD; for the Alzheimer’s Disease Neuroimaging Initiative Investigators
Includes: Supplemental Content

Importance  Cerebrospinal fluid (CSF) and positron emission tomographic (PET) amyloid biomarkers have been proposed for the detection of Alzheimer disease (AD) pathology in living patients and for the tracking of longitudinal changes, but the relation between biomarkers needs further study.

Objective  To determine the association between ...

Clinical Implications of Basic Neuroscience Research 
Oren J. Zarnett, BSc; Arjun Sahgal, MD; Jessica Gosio; James Perry, MD; Mitchel S. Berger, MD; Susan Chang, MD; Sunit Das, MD, PhD
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Importance  Despite improvements in survival with aggressive chemoradiation, outcomes for patients diagnosed as having glioblastoma multiforme (GBM) remain poor. Survival is further limited in elderly patients, who are often unable to tolerate multimodality therapy. The appropriate treatment approach for elderly patients (aged >65 years) with GBM remains ...

JAMA Neurology Clinical Challenge 
Lawrence S. Honig, MD, PhD
Pravin Khemani, MD; Richard B. Dewey Jr, MD

Parkinson disease (PD) is known to affect multiple neurotransmitter systems, resulting in both motor and nonmotor symptoms. Pain is an underrecognized but important nonmotor symptom of PD that may be very disabling and is known to impair quality of life.1 While significant progress has been made in ...

Original Investigation 
Marije R. Benedictus, MSc; Niels D. Prins, PhD; Jeroen D. C. Goos, PhD; Philip Scheltens, PhD; Frederik Barkhof, PhD; Wiesje M. van der Flier, PhD
Includes: Supplemental Content

Importance  Microbleeds are more prevalent in patients with Alzheimer disease (AD) compared with the general elderly population. In addition, microbleeds have been found to predict mortality in AD.

Objective  To investigate whether microbleeds in AD increase the risk for mortality, stroke (including intracerebral hemorrhage), and cardiovascular ...

Original Investigation 
Yu Jin Jung, MD; Han-Joon Kim, MD, PhD; Beom S. Jeon, MD, PhD; Hyeyoung Park, MD; Woong-Woo Lee, MD; Sun Ha Paek, MD, PhD
Includes: Supplemental Content

Importance  Pain is a common and distressing feature in Parkinson disease (PD). The major indication of subthalamic nucleus deep brain stimulation (STN DBS) is motor complications in advanced PD; however, pain reduction after STN DBS has been noted.

Objective  To evaluate the long-term effect of STN ...

Editorial: Subthalamic Nucleus Deep Brain Stimulation; Pravin Khemani, MD; Richard B. Dewey Jr, MD
Images in Neurology 
Fu-liang Zhang, MD; Yang Liu, MD; Ying-qi Xing, MD, PhD; Yi Yang, MD, PhD

A previously healthy woman in her 30s presented to the Department of Neurology at First Norman Bethune Hospital of Jilin University with thunderclap neck pain that radiated to the left occiput for 4 days after working for a long time at a computer with lateroversion of the neck. ...

This Viewpoint discusses the potential antiviral efficacy of fluoxetine in patients with enterovirus-D68–associated acute flaccid myelitis.

Original Investigation 
Niklas Mattsson, MD, PhD; Philip S. Insel, MSc; Michael Donohue, PhD; William Jagust, MD; Reisa Sperling, MD; Paul Aisen, MD, PhD; Michael W. Weiner, MD; for the Alzheimer’s Disease Neuroimaging Initiative
Includes: Supplemental Content

Importance  Alzheimer disease has a long preclinical stage characterized by β-amyloid (Aβ) accumulation without symptoms. Several trials focus on this stage and use biomarkers to include Aβ-positive participants, but an even earlier prevention of Aβ accumulation may be an effective treatment strategy.

Objective  To determine whether ...

Original Investigation 
Clifford R. Jack Jr, MD; Heather J. Wiste, BA; Stephen D. Weigand, MS; David S. Knopman, MD; Prashanthi Vemuri, PhD; Michelle M. Mielke, PhD; Val Lowe, MD; Matthew L. Senjem, MS; Jeffrey L. Gunter, PhD; Mary M. Machulda, PhD; Brian E. Gregg, BS; V. Shane Pankratz, PhD; Walter A. Rocca, MD, MPH; Ronald C. Petersen, MD, PhD
Includes: Supplemental Content

Importance  Typical cognitive aging may be defined as age-associated changes in cognitive performance in individuals who remain free of dementia. Ideally, the full adult age spectrum should be included to assess brain imaging findings associated with typical aging.

Objective  To compare age, sex, and APOE ε4 ...

Axel Montagne, PhD; Judy Pa, PhD; Berislav V. Zlokovic, MD, PhD

This Viewpoint discusses the role the hippocampus may play in dementia.

Peter T. Nelson, MD, PhD; Gregory A. Jicha, MD, PhD

In this issue of JAMA Neurology, Hohman et al1 provide new insights into a biomarker related to cognitive performance in advanced age. They report that elevated levels of vascular endothelial growth factor (VEGF) in cerebrospinal fluid (CSF) are associated with improved hippocampal volume, episodic memory, and ...

Original Investigation 
Timothy J. Hohman, PhD; Susan P. Bell, MBBS, MSCI; Angela L. Jefferson, PhD; for the Alzheimer’s Disease Neuroimaging Initiative
Includes: Supplemental Content

Importance  A subset of older adults present post mortem with Alzheimer disease (AD) pathologic features but without any significant clinical manifestation of dementia. Vascular endothelial growth factor (VEGF) has been implicated in staving off AD-related neurodegeneration.

Objective  To evaluate whether VEGF levels are associated with brain ...

Editorial: CSF Vascular Endothelial Growth Factor; Peter T. Nelson, MD, PhD; Gregory A. Jicha, MD, PhD
Original Investigation 
Carlo Rinaldi, MD, PhD; Thomas Schmidt, PhD; Alan J. Situ, BS; Janel O. Johnson, PhD; Philip R. Lee, PhD; Ke-lian Chen, BS; Laura C. Bott, MSc; Rut Fadó, PhD; George H. Harmison, MSc; Sara Parodi, PhD; Christopher Grunseich, MD; Benoît Renvoisé, PhD; Leslie G. Biesecker, MD; Giuseppe De Michele, MD; Filippo M. Santorelli, MD, PhD; Alessandro Filla, MD; Giovanni Stevanin, PhD; Alexandra Dürr, MD, PhD; Alexis Brice, MD, PhD; Núria Casals, PhD; Bryan J. Traynor, MD, PhD; Craig Blackstone, MD, PhD; Tobias S. Ulmer, PhD; Kenneth H. Fischbeck, MD
Includes: Supplemental Content

Importance  The family of genes implicated in hereditary spastic paraplegias (HSPs) is quickly expanding, mostly owing to the widespread availability of next-generation DNA sequencing methods. Nevertheless, a genetic diagnosis remains unavailable for many patients.

Objective  To identify the genetic cause for a novel form of pure ...

Kenneth S. Kosik, MA, MD

This Viewpoint evaluates the ways in which individualized evaluation in patients with Alzheimer disease may lead to more effective treatments.

Original Investigation 
Timothy B. Meier, PhD; Patrick S. F. Bellgowan, PhD; Rashmi Singh, PhD; Rayus Kuplicki, PhD; David W. Polanski, MS, ATC, LAT; Andrew R. Mayer, PhD
Includes: Supplemental Content

Importance  Animal models suggest that reduced cerebral blood flow (CBF) is one of the most enduring physiological deficits following concussion. Despite this, longitudinal studies documenting serial changes in regional CBF following human concussion have yet to be performed.

Objective  To longitudinally assess the recovery of CBF ...

E. Ray Dorsey, MD, MBA; Charles Venuto, PharmD; Vinayak Venkataraman, BSE; Denzil A. Harris, BA; Karl Kieburtz, MD, MPH
Includes: Supplemental Content

Importance  New technologies are rapidly reshaping health care. However, their effect on drug development to date generally has been limited.

Objectives  To evaluate disease modeling and simulation, alternative study design, novel objective measures, virtual research visits, and enhanced participant engagement and to examine their potential effects ...

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