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 Showing 21-40 of 53 Articles
Comment & Response 
Marijn M. Speeckaert, MD, PhD; Joris R. Delanghe, MD, PhD

To the Editor We read with interest the article by Miller et al.1 In a general population, it was demonstrated for the first time that vitamin D insufficiency, which was more frequently observed in African American and Hispanic individuals, was associated with significantly faster declines in both ...

Comment & Response 
Joshua W. Miller, PhD; Ralph Green, MD, PhD; Charles DeCarli, MD

In Reply Muratli et al raise the critical issue of whether there is a cause and effect relationship between low vitamin D status and accelerated rates of cognitive decline in older adults. We agree that dementia may lead to reduced vitamin D status owing to reduced exposure to ...

Comment & Response 
Sevilay Muratli, MD; Ozlem Soyluk, MD; Fatih Tufan

To the Editor We read with interest the well-designed study by Miller et al.1Vitamin D deficiency (VDD) is an important health problem in elderly individuals, and the association of VDD and cognitive functions is an area that has drawn significant interest. There is also a great ...

Viewpoint 
Ryan D. Jacobson, MD; Eva L. Feldman, MD, PhD

This Viewpoint discusses the use of exon skipping therapies eteplirsen and drisapersen in Duchenne muscular dystrophy.

In this issue of JAMA Neurology, Mez and colleagues1 present a case of a young former amateur football player diagnosed with chronic traumatic encephalopathy (CTE), identified pathologically at autopsy at age 25 years, following death due to complications of endocarditis. This athlete is just one in ...

Original Investigation 
Sandeep Kumar, MD; Magdy Selim, MD, PhD; Sarah Marchina, PhD; Louis R. Caplan, MD
Includes: Supplemental Content

Importance  Transient symptoms from an intracerebral hemorrhage (ICH) are not well recognized and have previously not been reported.

Objective  To describe the clinical presentations and neuroimaging findings in a subset of patients with ICH presenting with transient neurological signs and symptoms.

Design, Setting, and Participants  ...

Original Investigation 
Michael F. Waters, MD, PhD; Brian L. Hoh, MD; Michael J. Lynn, MS; Hyung-Min Kwon, MD; Tanya N. Turan, MD; Colin P. Derdeyn, MD; David Fiorella, MD, PhD; Anna Khanna, MD; Tiffany O. Sheehan, BSN; Bethany F. Lane, RN; Scott Janis, PhD; Jean Montgomery, RN; Marc I. Chimowitz, MBChB; for the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) Trial Investigators

Importance  The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) Trial showed that aggressive medical therapy was more effective than stenting for preventing stroke in patients with symptomatic intracranial stenosis. However, 15% of patients in the medical group still experienced a primary ...

Images in Neurology 
Salvatore Rudilosso, MD; Xabier Urra, MD, PhD; Oscar Chirife, MD; Ángel Chamorro, MD, PhD

This article describes 2 cases where computed tomography perfusion showed acute ischemic lesions not visible on diffusion-weighted imaging.

Observation 
Jesse Mez, MD, MS; Todd M. Solomon, PhD; Daniel H. Daneshvar, MA; Thor D. Stein, MD, PhD; Ann C. McKee, MD

This case report describes a 25-year-old former college football player who had more than 10 concussions while playing football and postmortem pathologically confirmed chronic traumatic encephalopathy.

Editorial: Understanding Chronic Traumatic Encephalopathy; James M. Noble, MD, MS, CPH
Original Investigation 
David M. Greer, MD, MA; Hilary H. Wang, BA; Jennifer D. Robinson, APRN; Panayiotis N. Varelas, MD, PhD; Galen V. Henderson, MD; Eelco F. M. Wijdicks, MD, PhD
Includes: Supplemental Content

Importance  Brain death is the irreversible cessation of function of the entire brain, and it is a medically and legally accepted mechanism of death in the United States and worldwide. Significant variability may exist in individual institutional policies regarding the determination of brain death. It is imperative ...

Original Investigation 
Eitan Auriel, MD, MSc; Andreas Charidimou, MD, PhD; M. Edip Gurol, MD, MSc; Jun Ni, MD; Ellis S. Van Etten, MD; Sergi Martinez-Ramirez, MD; Gregoire Boulouis, MD; Fabrizio Piazza, PhD; Jacopo C. DiFrancesco, MD, PhD; Matthew P. Frosch, MD, PhD; Octάvio M. Pontes-Neto, MD, PhD; Ashkan Shoamanesh, MD; Yael Reijmer, PhD; Anastasia Vashkevich, BA; Alison M. Ayres, BA; Kristin M. Schwab, BA; Anand Viswanathan, MD, PhD; Steven M. Greenberg, MD, PhD

Importance  Cerebral amyloid angiopathy–related inflammation (CAA-ri) is an important diagnosis to reach in clinical practice because many patients with the disease respond to immunosuppressive therapy. Reliable noninvasive diagnostic criteria for CAA-ri would allow some patients to avoid the risk of brain biopsy.

Objective  To test the ...

Review 
Erin E. Longbrake, MD, PhD; Anne H. Cross, MD

The unequivocal success of B-cell–depleting agents in reducing magnetic resonance imaging and clinical activity in therapeutic trials indicates that B cells play a vital role in mediating the clinical course of relapsing multiple sclerosis (MS). Although no agent that specifically targets B cells has yet been approved for ...

Images in Neurology 
Patricia H. McNamara, MRCPUK, PhD; Jennifer Williams, MRCPI; Dominick J. H. McCabe, PhD, FRCPI; Richard A. Walsh, MD, MRCPI

This case report describes of a man in his 70s with known alcohol dependence syndrome whose neuroimaging revealed a striking triangular central pontine defect in keeping with central pontine myelinolysis.

Comment & Response 
Yi-cheng Tai, MD; Michael Wang Keong Fong, MBBS(Hons); Victor S. C. Fung, MBBS(Hons), PhD, FRACP

To the Editor We read with interest the report by Pandey and Sarma1 of a patient with an acute left thalamic infarction who developed seemingly purposeless tapping movements in the right hand. In the accompanying video, the movement on day 6 was confined to the right hand, ...

Comment & Response 
Sanjay Pandey, DM; Neelav Sarma, MD

In Reply We thank Tai and colleagues for their comments regarding our article.1

Viewpoint 
Nicholas E. Johnson, MD; Amy Kaloides, BA; Elaine Jones, MD

This Viewpoint examines the reforms needed in the field of neurology after the repeal of the sustainable growth rate.

Editorial 
James F. Meschia, MD

Symptomatic atherosclerosis of the vertebral artery remains a challenging condition with no proven interventional therapy. Completed randomized trials of angioplasty with or without stenting involving patients with symptomatic vertebral artery stenosis include Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS),1 Stenting vs Aggressive Medical Management for Preventing ...

Original Investigation 
Sepideh Amin-Hanjani, MD; Dilip K. Pandey, MD, PhD; Linda Rose-Finnell, MPA; Xinjian Du, MD, MPH; DeJuran Richardson, PhD; Keith R. Thulborn, MD, PhD; Mitchell S. V. Elkind, MD, MS; Gregory J. Zipfel, MD; David S. Liebeskind, MD; Frank L. Silver, MD; Scott E. Kasner, MD; Victor A. Aletich, MD; Louis R. Caplan, MD; Colin P. Derdeyn, MD; Philip B. Gorelick, MD, MPH; Fady T. Charbel, MD; for the Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) Study Group
Includes: Supplemental Content

Importance  Atherosclerotic vertebrobasilar (VB) occlusive disease is a significant etiology of posterior circulation stroke, with regional hypoperfusion as an important potential contributor to stroke risk.

Objective  To test the hypothesis that, among patients with symptomatic VB stenosis or occlusion, those with distal blood flow compromise as ...

Editorial: The High Risk of Low Distal Flow; James F. Meschia, MD
Original Investigation 
Puck S. S. Fransen, MD; Olvert A. Berkhemer, MD; Hester F. Lingsma, PhD; Debbie Beumer, MD; Lucie A. van den Berg, MD; Albert J. Yoo, MD; Wouter J. Schonewille, MD, PhD; Jan Albert Vos, MD, PhD; Paul J. Nederkoorn, MD, PhD; Marieke J. H. Wermer, MD, PhD; Marianne A. A. van Walderveen, MD, PhD; Julie Staals, MD, PhD; Jeannette Hofmeijer, MD, PhD; Jacques A. van Oostayen, MD, PhD; Geert J. Lycklama à Nijeholt, MD, PhD; Jelis Boiten, MD, PhD; Patrick A. Brouwer, MD; Bart J. Emmer, MD, PhD; Sebastiaan F. de Bruijn, MD, PhD; Lukas C. van Dijk, MD; L. Jaap Kappelle, MD, PhD; Rob H. Lo, MD; Ewoud J. van Dijk, MD, PhD; Joost de Vries, MD, PhD; Paul L. M. de Kort, MD, PhD; J. S. Peter van den Berg, MD, PhD; Boudewijn A. A. M. van Hasselt, MD; Leo A. M. Aerden, MD, PhD; René J. Dallinga, MD; Marieke C. Visser, MD, PhD; Joseph C. J. Bot, MD, PhD; Patrick C. Vroomen, MD, PhD; Omid Eshghi, MD; Tobien H. C. M. L. Schreuder, MD; Roel J. J. Heijboer, MD; Koos Keizer, MD, PhD; Alexander V. Tielbeek, MD, PhD; Heleen M. den Hertog, MD, PhD; Dick G. Gerrits, MD; Renske M. van den Berg-Vos, MD, PhD; Giorgos B. Karas, MD, PhD, MBA; Ewout W. Steyerberg, PhD; H. Zwenneke Flach, MD; Henk A. Marquering, PhD; Marieke E. S. Sprengers, MD, PhD; Sjoerd F. M. Jenniskens, MD, PhD; Ludo F. M. Beenen, MD; René van den Berg, MD, PhD; Peter J. Koudstaal, MD, PhD; Wim H. van Zwam, MD, PhD; Yvo B.W. E. M. Roos, MD, PhD; Robert J. van Oostenbrugge, MD, PhD; Charles B. L. M. Majoie, MD, PhD; Aad van der Lugt, MD, PhD; Diederik W. J. Dippel, MD, PhD; for the Multicenter Randomized Clinical Trial of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands (MR CLEAN) investigators
Includes: Supplemental Content

Importance  Intra-arterial treatment (IAT) for acute ischemic stroke caused by intracranial arterial occlusion leads to improved functional outcome in patients treated within 6 hours after onset. The influence of treatment delay on treatment effect is not yet known.

Objective  To evaluate the influence of time from ...

Comment & Response 
Sevilay Muratli, MD; Ozlem Soyluk, MD; Fatih Tufan, MD

To the Editor We read the article by Willette et al1 with interest. The findings of this study are important because insulin resistance is a growing health problem, and measures to decrease the incidence of Alzheimer disease (AD) are urgently needed. However, we have some comments on ...

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