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 Showing 1-20 of 53 Articles
Steven T. DeKosky, MD; John H. Growdon, MD

This Viewpoint outlines the roles and interactions of organizations conducting research leadsing to effective treatments for Alzheimer disease.

Wolf-Dieter Heiss, MD

The burden of cerebrovascular disease is high: each year, approximately 795 000 people in the United States experience a new or recurrent stroke, leading to death in 128 824 individuals or being associated with death in 215 864 cases.1 However, the number of silent infarcts and microhemorrhages is much higher, ...

Original Investigation  FREE
Helena M. van der Holst, MD; Ingeborg W. M. van Uden, MD; Anil M. Tuladhar, MD; Karlijn F. de Laat, MD, PhD; Anouk G. W. van Norden, MD, PhD; David G. Norris, PhD; Ewoud J. van Dijk, MD, PhD; Loes C. Rutten-Jacobs, PhD; Frank-Erik de Leeuw, MD, PhD
Includes: Supplemental Content

Importance  Gait and cognition have been related to mortality in population-based studies. This association is possibly mediated by cerebral small vessel disease (SVD), which has been associated with mortality as well. It is unknown which factors can predict mortality in individuals with SVD. Identification of high-risk patients ...

Original Investigation 
Rabe E. Alhurani, MBBS; Maria Vassilaki, MD, PhD; Jeremiah A. Aakre, MPH; Michelle M. Mielke, PhD; Walter K. Kremers, PhD; Mary M. Machulda, PhD; Yonas E. Geda, MD, MSc; David S. Knopman, MD; Ronald C. Peterson, MD, PhD; Rosebud O. Roberts, MB, ChB

Importance  Unintentional weight loss has been associated with risk of dementia. Because mild cognitive impairment (MCI) is a prodromal stage for dementia, we sought to evaluate whether changes in weight and body mass index (BMI) may predict incident MCI.

Objective  To investigate the association of change ...

Pierre R. Bourque, MD, FRCPC; Sharmi Shafi, MD; Gerard H. Jansen, MD, FRCPC; Arleigh McCurdy, MD, FRCPC; Jodi Warman Chardon, MD, FRCPC

This case report describes possible stabilization of liver transplant–acquired amyloid neuropathy with diflunisal.

The US Preventive Services Task Force (USPSTF) has offered its updated recommendations for the screening for depression in adults. The document, published this week in JAMA,1 updates a 2009 review of the evidence as to the net benefit of accurate diagnosis, effective treatment, and appropriate follow-up ...

The results of recently completed clinical trials15 of acute ischemic stroke that report a clear and unequivocal benefit of stent-retriever devices used with intravenous recombinant tissue plasminogen activator (rtPA) vs rtPA alone are the second revolutionary therapeutic breakthrough in acute stroke care in the last ...

Magnetic resonance imaging (MRI) is a powerful tool that allows us to not only assess atrophic patterns associated with disease but to start to unravel the complex associations between regional tissue loss and specific clinical symptoms. Patterns of atrophy associated with frontotemporal dementia (FTD) and its clinical variants ...

Original Investigation  FREE
Lahoud Touma; Kristian B. Filion, PhD; Lee H. Sterling; Renée Atallah, MSc; Sarah B. Windle, MPH; Mark J. Eisenberg, MD, MPH
Includes: Supplemental Content

Importance  Stent retrievers are a promising alternative for the treatment of acute ischemic stroke (AIS). Several recently completed clinical trials have examined the use of stent retrievers with intravenous recombinant tissue plasminogen activator (rtPA) compared with rtPA alone.

Objective  To conduct a systematic review and meta-analysis ...

Editorial: Recombinant Tissue Plasminogen Activator Stroke Therapy; Raphael A. Carandang, MD
Original Investigation 
Rebekah M. Ahmed, MBBS; Muireann Irish, PhD; Elana Henning, BSc; Nadene Dermody, BSc; Lauren Bartley, BSc; Matthew C. Kiernan, DSc; Olivier Piguet, PhD; Sadaf Farooqi, MB, ChB, PhD; John R. Hodges, MD
Includes: Supplemental Content

Importance  Abnormal eating behaviors are common in patients with frontotemporal dementia (FTD), yet their exact prevalence, severity, and underlying biological mechanisms are not understood.

Objective  To define the severity of abnormal eating behavior and sucrose preference and their neural correlates in patients with behavioral variant FTD ...

Images in Neurology 
Aakash S. Shetty, MBBS, MD, DM; Ritu Kashikar, MBBS, DNB; Aabha Nagral, MBBS, MD, DNB; Pettarusp M. Wadia, MD, DM, DNB

This case report discusses a patient with Wilson disease with unusual extensive cortical cystic lesions and partial poor response to decupuration and seizures.

JAMA Neurology Clinical Challenge 
Treasach C. Vargas, DO; Richard L. Thomas, DO; Jay C. Erickson, MD, PhD

A 69-year-old white man presented to the emergency department reporting 2 months of progressive bilateral lower extremity weakness, left facial weakness, and diplopia in the setting of a 20.4-kg weight loss over the previous 6 months and new onset urinary incontinence. What is your diagnosis?

Hannah Machemehl, BS; Dala Eloubeidi; Hassan Fathallah-Shaykh, MD, PhD

This Viewpoint provides examples of diseases to illustrate how the understanding of neurological disease has evolved from an elementary mendelian view.

J. Eric Ahlskog, PhD, MD

Physical and occupational therapy have long been components of Parkinson disease (PD) treatment. Prior to the advent of levodopa, this was a primary therapeutic modality. What is the current role for physical therapy in PD? Should everyone with PD be referred? Is it cost-effective? What should be the ...

Original Investigation 
Hooi-Ling Teoh, MBBS; Shekeeb S. Mohammad, FRACP; Philip N. Britton, FRACP; Tejaswi Kandula, FRACP; Michelle S. Lorentzos, MBBS; Robert Booy, PhD; Cheryl A. Jones, PhD; William Rawlinson, PhD; Vidiya Ramachandran, MBBS; Michael L. Rodriguez, FRCPA; P. Ian Andrews, FRACP; Russell C. Dale, PhD; Michelle A. Farrar, PhD; Hugo Sampaio, FRACP
Includes: Supplemental Content

Importance  Enterovirus 71 (EV71) causes a spectrum of neurological complications with significant morbidity and mortality. Further understanding of the characteristics of EV71-related neurological disease, factors related to outcome, and potential responsiveness to treatments is important in developing therapeutic guidelines.

Objective  To further characterize EV71-related neurological disease ...

Original Investigation 
Carl E. Clarke, MD; Smitaa Patel, MSc; Natalie Ives, MSc; Caroline E. Rick, PhD; Francis Dowling, BSc; Rebecca Woolley, MSc; Keith Wheatley, DPhil; Marion F. Walker, PhD; Catherine M. Sackley, PhD; for the PD REHAB Collaborative Group
Includes: Supplemental Content

Importance  It is unclear whether physiotherapy and occupational therapy are clinically effective and cost-effective in Parkinson disease (PD).

Objective  To perform a large pragmatic randomized clinical trial to evaluate the clinical effectiveness of individualized physiotherapy and occupational therapy in PD.

Design, Setting, and Participants  The ...

Editorial: Goals for Parkinson Disease Physical Therapy; J. Eric Ahlskog, PhD, MD
Original Investigation 
Yvonne L. Eaglehouse, PhD, MPH; Evelyn O. Talbott, DrPH; Yuefang Chang, PhD; Lewis H. Kuller, MD, DrPH
Includes: Supplemental Content

Importance  Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease with no known cause. Case studies primarily of athletes and several case-control studies have suggested that high levels of strenuous physical activity (PA) may increase the risk for ALS. This relationship has yet to be evaluated among ...

Original Investigation 
Anne-Marie A. Wills, MD, MPH; Adriana Pérez, PhD; Jue Wang, MS; Xiao Su, BSc; John Morgan, MD; Suja S. Rajan, PhD; Maureen A. Leehey, MD; Gregory M. Pontone, MD; Kelvin L. Chou, MD; Chizoba Umeh, MD; Zoltan Mari, MD; James Boyd, MD; for the NINDS Exploratory Trials in Parkinson Disease (NET-PD) Investigators

Importance  Greater body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) is associated with improved survival among persons with Huntington disease or amyotrophic lateral sclerosis. Weight loss is common among persons with Parkinson disease (PD) and is associated with worse quality ...

Original Investigation 
Panayiota Petrou, MD; Yael Gothelf, PhD; Zohar Argov, MD; Marc Gotkine, MD; Yossef S. Levy, PhD; Ibrahim Kassis, PhD; Adi Vaknin-Dembinsky, MD; Tamir Ben-Hur, MD; Daniel Offen, PhD; Oded Abramsky, MD; Eldad Melamed, MD†; Dimitrios Karussis, MD, PhD
Includes: Supplemental Content

Importance  Preclinical studies have shown that neurotrophic growth factors (NTFs) extend the survival of motor neurons in amyotrophic lateral sclerosis (ALS) and that the combined delivery of these neurotrophic factors has a strong synergistic effect. We have developed a culture-based method for inducing mesenchymal stem cells (MSCs) ...

Amy K. Forrestel, MD; Badri G Modi, MD; Sarah Longworth, MD; Marissa B. Wilck, MD; Robert G. Micheletti, MD

A 62-year-old woman with multiple sclerosis treated with fingolimod for 3 years presented to clinic with a tender nodule on the forehead that was diagnosed by a tissue culture as Cryptococcus neoformans. The patient was diagnosed with primary cutaneous cryptococcosis.

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