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 Showing 1-20 of 62 Articles

Childhood stroke studies often cite differences in risk factors between adult and pediatric patients, namely that traditional adult stroke risk factors, such as hypertension and hyperglycemia, are not common causes of childhood stroke.14 In a study2 of 83 children from the United Kingdom, only ...

Stephen W. Clark, MD, PhD

The world’s population is aging and rapidly increasing; it is estimated to reach 9.4 billion in 2050, with 1.5 billion people older than 65 years.1 In parallel to an aging population, cancer incidence is expected to rise, and in 2035 it is estimated that 70% of diagnosed ...

Original Investigation  FREE
Chad G. Rusthoven, MD; Matthew Koshy, MD; David J. Sher, MD; Douglas E. Ney, MD; Laurie E. Gaspar, MD; Bernard L. Jones, PhD; Sana D. Karam, MD, PhD; Arya Amini, MD; D. Ryan Ormond, MD; A. Samy Youssef, MD, PhD; Brian D. Kavanagh, MD
Includes: Supplemental Content

Importance  The optimal management for elderly patients with glioblastoma (GBM) is controversial. Following maximal safe resection or biopsy, accepted treatment paradigms for elderly patients with GBM include combined-modality therapy (CMT) with both radiotherapy (RT) and chemotherapy (CT), RT alone, and CT alone.

Objective  To evaluate the ...

Editorial: The Age Factor in the Treatment of Glioblastoma; Stephen W. Clark, MD, PhD
Original Investigation 
Kimberly N. Grelli, MD; Melissa C. Gindville, MS; C. Haley Walker, BA; Lori C. Jordan, MD, PhD
Includes: Supplemental Content

Importance  To our knowledge, no evidence-based guidelines are available for the best medical management of blood pressure, blood glucose levels, and temperature in pediatric patients after arterial ischemic stroke.

Objective  To determine the prevalence of abnormal blood pressure, blood glucose levels, and temperature in pediatric patients ...

Clinical Pathologic Conference 
Nathan H. Kung, MD; Robert C. Bucelli, MD, PhD; Renee B. Van Stavern, MD; Joel A. Goebel, MD; Gregory P. Van Stavern, MD
Includes: Supplemental Content

A 37-year-old man with a history of progressive bilateral sensorineural hearing loss presented to a neuro-ophthalmology clinic with an acute left homonymous hemianopsia. In this article, we discuss the clinical approach and differential diagnosis of progressive combined vision and hearing loss and guide the reader to discover the ...

Comment & Response 
Rita Cardoso, SLT, MSc; Diana Miranda, RDN; Joaquim J. Ferreira, MD, PhD

To the Editor In the article by Wills and coauthors,1 it is hypothesized that a lower body mass index (BMI) in Parkinson disease (PD) is associated with shorter survival based on the extrapolation from the association found in Huntington disease and amyotrophic lateral sclerosis. However, it is ...

Comment & Response 
Anne-Marie Wills, MD; James Boyd, MD; Adriana Pérez, PhD

In Reply We wish to clarify that our study1 was not designed to look at nutritional status in Parkinson disease. The article that we cited by Paganoni et al2 on the association between body mass index and amyotrophic lateral sclerosis found a dose-dependent effect of body ...

The ability to diagnose the pathology of neurodegenerative diseases in patients during life remains one of the holy grails of behavioral neurology. Considerable progress has been made over the past decade or so. We can now accurately predict the pathology—Alzheimer disease (AD) with plaques and tangles—in patients with ...

Original Investigation 
Noah A. Kolb, MD; A. Gordon Smith, MD; J. Robinson Singleton, MD; Susan L. Beck, PhD, APRN, AOCN; Gregory J. Stoddard, MS; Summer Brown, MD; Kathi Mooney, PhD, RN

Importance  Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of neurotoxic chemotherapy resulting in pain, sensory loss, and decreased quality of life. Few studies have prospectively examined the relationship between sensory neuropathy symptoms, falls, and fall-related injuries for patients receiving neurotoxic chemotherapy.

Objective  To determine ...

Original Investigation 
Stephanie Kielb, MS; Amanda Cook, MA; Christina Wieneke, BA; Alfred Rademaker, PhD; Eileen H. Bigio, MD; Marek-Marsel Mesulam, MD; Emily Rogalski, PhD; Sandra Weintraub, PhD

Importance  The dementia syndrome of primary progressive aphasia (PPA) can be caused by 1 of several neuropathologic entities, including forms of frontotemporal lobar degeneration (FTLD) or Alzheimer disease (AD). Although episodic memory is initially spared in this syndrome, the subtle learning and memory features of PPA and ...

Review  FREE
J. David Beckham, MD; Daniel M. Pastula, MD, MHS; Aaron Massey, MS; Kenneth L. Tyler, MD

Importance  Zika virus (ZIKV) is an emerging arthropod-borne virus (arbovirus) in the genus Flavivirus that has caused a widespread outbreak of febrile illness, is associated with neurological disease, and has spread across the Pacific to the Americas in a short period.

Observations  In this review, we ...

Toshitaka Kawarai, MD; Ryosuke Miyamoto, MD; Yoshimitsu Shimatani, MD; Antonio Orlacchio, MD, PhD; Ryuji Kaji, MD

This case series describes members of the same family with spinocerebellar ataxia type 16 with choreoathetosis, dystonia, and myoclonus.

Jacquelyn J. Cragg, PhD; Merit E. Cudkowicz, MD, FRCPC; Marc G. Weisskopf, PhD

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that carries a high degree of disability and eventually leads to respiratory failure. The incidence of ALS is estimated to be approximately 2 to 3 per 100 000 per year.1 Between October 2010 and December 2011, the US National ...

Juan M. Pascual, MD, PhD

Epilepsies caused by mutation of unexcitable, non–ion channel gene products constitute an important and active area of investigation. Genes involved in virtually all kinds of intracellular processes have been linked to abnormalities in neural membrane excitability and epilepsy. Among these, the MTOR gene is a prominent example. Mammalian ...

Original Investigation 
Ghayda M. Mirzaa, MD; Catarina D. Campbell, PhD; Nadia Solovieff, PhD; Carleton P. Goold, PhD; Laura A. Jansen, MD, PhD; Suchithra Menon, PhD; Andrew E. Timms, PhD; Valerio Conti, BSc, PhD; Jonathan D. Biag, MS; Carissa Olds, MSc; Evan August Boyle, BS; Sarah Collins, MS; Gisele Ishak, MD; Sandra L. Poliachik, PhD; Katta M. Girisha, MD; Kit-San Yeung, BSc, MPhil; Brian Hon Yin Chung, MD; Elisa Rahikkala, MD, PhD; Sonya A. Gunter, MS; Sharon S. McDaniel, MD; Colleen Forsyth Macmurdo, DO; Jonathan A. Bernstein, MD, PhD; Beth Martin, BS; Rebecca J. Leary, PhD; Scott Mahan, MT(ASCP); Shanming Liu, MSc; Molly Weaver, BS; Michael O. Dorschner, PhD; Shalini Jhangiani, MS; Donna M. Muzny, MSc; Eric Boerwinkle, PhD; Richard A. Gibbs, PhD; James R. Lupski, MD, PhD, DSc(Hon); Jay Shendure, MD, PhD; Russell P. Saneto, DO, PhD; Edward J. Novotny, MD; Christopher J. Wilson, PhD; William R. Sellers, MD; Michael P. Morrissey, PhD; Robert F. Hevner, MD, PhD; Jeffrey G. Ojemann, MD; Renzo Guerrini, MD; Leon O. Murphy, PhD; Wendy Winckler, PhD; William B. Dobyns, MD
Includes: Supplemental Content

Importance  Focal cortical dysplasia (FCD), hemimegalencephaly, and megalencephaly constitute a spectrum of malformations of cortical development with shared neuropathologic features. These disorders are associated with significant childhood morbidity and mortality.

Objective  To identify the underlying molecular cause of FCD, hemimegalencephaly, and diffuse megalencephaly.

Design, Setting, and ...

Editorial: Genetic Gradients in Epileptic Brain Malformations; Juan M. Pascual, MD, PhD
Original Investigation  FREE
Feng-Chiao Su, PhD; Stephen A. Goutman, MD; Sergey Chernyak, PhD; Bhramar Mukherjee, PhD; Brian C. Callaghan, MD; Stuart Batterman, PhD; Eva L. Feldman, MD, PhD
Includes: Supplemental Content

Importance  Persistent environmental pollutants may represent a modifiable risk factor involved in the gene-time-environment hypothesis in amyotrophic lateral sclerosis (ALS).

Objective  To evaluate the association of occupational exposures and environmental toxins on the odds of developing ALS in Michigan.

Design, Setting, and Participants  Case-control study ...

Editorial: The Role of Environmental Toxins in Amyotrophic Lateral Sclerosis Risk; Jacquelyn J. Cragg, PhD; Merit E. Cudkowicz, MD, FRCPC; Marc G. Weisskopf, PhD
Images in Neurology 
Nikisha Kothari, MD; Ajay E. Kuriyan, MD

This case report describes a woman in her early 40s who presented to the emergency department with multiple scotomas in both eyes and auditory changes in her left ear.

Comment & Response 
Simone Gallerini, MD; Luca Marsili, MD; Roberto Marconi, MD

To the Editor We read with interest the study by Armangué and colleagues1 about the clinical and immunological features of opsoclonus-myoclonus syndrome (OMS). Opsoclonus-myoclonus syndrome is a rare movement disorder characterized by involuntary saccades, limb myoclonus, and cerebellar ataxia.2 Its etiology is idiopathic or paraneoplastic (P-OMS). ...

Comment & Response 
Francesc Graus, MD, PhD; Helena Ariño, MD; Josep Dalmau, MD, PhD

In Reply We thank Gallerini and colleagues for bringing to our attention a new case of opsoclonus associated with a gastric adenocarcinoma. The patient confirms the tight association of older age with a paraneoplastic etiology of the opsoclonus.1

Sara K. Rostanski, MD; Randolph S. Marshall, MD, MS

This Viewpoint discusses the future of precision medicine in the field of ischemic stroke, first looking at the current status of genetic approaches and then exploring the status of phenotype-based delineations.

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