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 Showing 1-20 of 34 Articles
Original Investigation 
Kerstin Hellwig, MD; Milena Rockhoff, MD; Sandra Herbstritt, PharmD; Nadja Borisow, MD; Aiden Haghikia, MD; Birte Elias-Hamp, MD; Sylvia Menck, MD; Ralf Gold, MD; Annette Langer-Gould, MD, PhD

Importance  Women with multiple sclerosis (MS) experience an elevated risk of relapse after giving birth. The effect of exclusive breastfeeding on postpartum risk of MS relapse is unclear.

Objectives  To determine the effect of exclusive breastfeeding on postpartum risk of MS relapse and to investigate the ...

Special Communication 
Michelle Bowman, MD; Michael Racke, MD; John Kissel, MD; Jaime Imitola, MD

“Stem cell tourism” is a rising Internet-based industry that aims to offer unproven procedures to patients with incurable diseases. This unregulated activity is reaching the neurologist’s office as well as across the world, as patients request information or clearance for such procedures. Herein, we posit the need for ...

Editorial 
Stephen Salloway, MD, MS; Reisa Sperling, MD, MMSc

How accurate is the clinical diagnosis of Alzheimer disease (AD), and can we identify factors that predict other etiologies for dementia? In this issue of JAMA Neurology, Monsell et al1 report that 25% of individuals clinically diagnosed as having mild to moderate Alzheimer dementia with a ...

Original Investigation 
Sarah E. Monsell, MS; Walter A. Kukull, PhD; Alex E. Roher, MD, PhD; Chera L. Maarouf, BS; Geidy Serrano, PhD; Thomas G. Beach, MD, PhD; Richard J. Caselli, MD; Thomas J. Montine, MD, PhD; Eric M. Reiman, MD
Includes: Supplemental Content

Importance  β-Amyloid peptide (Aβ) plaques are a cardinal neuropathologic feature of Alzheimer disease (AD), yet more than one-third of apolipoprotein E ε4 (APOE4) noncarriers with the clinical diagnosis of mild to moderate Alzheimer dementia may not meet positron emission tomographic criteria for significant cerebral amyloidosis....

Editorial: Conflicting Neuropathological Findings in Alzheimer Dementia; Stephen Salloway, MD, MS; Reisa Sperling, MD, MMSc
Original Investigation  FREE
Mark H. Tuszynski, MD, PhD; Jennifer H. Yang, BS; David Barba, MD; Hoi-Sang U, MD; Roy A. E. Bakay, MD; Mary M. Pay, NP; Eliezer Masliah, MD; James M. Conner, PhD; Peter Kobalka, MD; Subhojit Roy, MD, PhD; Alan H. Nagahara, PhD
Includes: Supplemental Content

Importance  Alzheimer disease (AD) is the most common neurodegenerative disorder and lacks effective disease-modifying therapies. In 2001, we initiated a clinical trial of nerve growth factor (NGF) gene therapy in AD, the first effort at gene delivery in an adult neurodegenerative disorder. This program aimed to determine ...

Original Investigation  FREE
Mark H. B. Huisman, MD; Meinie Seelen, MD, PhD; Perry T. C. van Doormaal, MD; Sonja W. de Jong, MD, PhD; Jeanne H. M. de Vries, PhD; Anneke J. van der Kooi, MD, PhD; Marianne de Visser, MD, PhD; H. Jurgen Schelhaas, MD, PhD; Leonard H. van den Berg, MD, PhD; Jan H. Veldink, MD, PhD
Includes: Supplemental Content

Importance  Because dietary intake may influence pathophysiologic mechanisms in sporadic amyotrophic lateral sclerosis (ALS), the association between premorbid dietary intake and the risk of sporadic ALS will provide insight into which mechanisms are possibly involved in ALS pathophogenesis.

Objective  To systematically determine the association between premorbid ...

Original Investigation 
Stefanie Schreiber, MD; Susan M. Landau, PhD; Allison Fero, BSc; Frank Schreiber, MSc; William J. Jagust, MD; for the Alzheimer’s Disease Neuroimaging Initiative
Includes: Supplemental Content

Importance  The applicability of β-amyloid peptide (Aβ) positron emission tomography (PET) as a biomarker in clinical settings to aid in selection of individuals at preclinical and prodromal Alzheimer disease (AD) will depend on the practicality of PET image analysis. In this context, visual-based Aβ PET assessment seems ...

Original Investigation 
Bastien Joubert, MD; Philippe Kerschen, MD; Anastasia Zekeridou, MD; Virginie Desestret, MD, PhD; Véronique Rogemond, PhD; Marie-Océane Chaffois, BTech; François Ducray, MD, PhD; Vincent Larrue, MD, PhD; Benoit Daubail, MD; Ahmed Idbaih, MD, PhD; Dimitri Psimaras, MD; Jean-Christophe Antoine, MD, PhD; Jean-Yves Delattre, MD, PhD; Jérôme Honnorat, MD, PhD
Includes: Supplemental Content

Importance  The clinical features of autoimmune encephalitis associated with antibodies against the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR-Abs) remain poorly defined.

Objectives  To describe 7 patients with encephalitis and AMPAR-Abs and to provide a review of the literature on this disease entity.

Design, Setting, and Participants  The ...

Images in Neurology 
Jung E. Park, MD; Katharine Alter, MD; Mark Hallett, MD

This case report describes involuntary lingual dyskinesia with nearly continuous rhythmic movements of the genioglossus in a patient with multiple sclerosis.

Original Investigation 
Crandall E. Peeler, MD; Lindsey B. De Lott, MD; Lina Nagia, DO; Joao Lemos, MD; Eric R. Eggenberger, DO, MSEpi; Wayne T. Cornblath, MD

Importance  The sensitivity of acetylcholine receptor (AChR) antibody testing is thought to be lower in ocular myasthenia gravis (OMG) compared with generalized disease, although estimates in small-scale studies vary. There is little information in the literature about the implications of AChR antibody levels and progression from OMG ...

Original Investigation 
David C. Bäckström, MD; Magdalena Eriksson Domellöf, PhD; Jan Linder, MD, PhD; Bob Olsson, PhD; Annika Öhrfelt, PhD; Miles Trupp, PhD; Henrik Zetterberg, MD, PhD; Kaj Blennow, MD, PhD; Lars Forsgren, MD, PhD
Includes: Supplemental Content

Importance  Alterations in cerebrospinal fluid (CSF) have been found in Parkinson disease (PD) and in PD dementia (PDD), but the prognostic importance of such changes is not well known. In vivo biomarkers for disease processes in PD are important for future development of disease-modifying therapies.

Objective  ...

Original Investigation  FREE
Matthew Schrag, MD; Teddy Youn, MD; Joseph Schindler, MD; Howard Kirshner, MD; David Greer, MD

Importance  Central retinal artery occlusion (CRAO) is an ophthalmologic emergency that can result in blindness. At present, no proven therapy for CRAO exists. Treatment with fibrinolytic agents has shown promise but remains of unproven benefit.

Objectives  To assess the efficacy of systemic fibrinolytic therapy for patients ...

Images in Neurology 
José Rafael P. Zuzuárregui, MD; Samuel A. Frank, MD

This case report describes ataxia with uncontrollable palatal tremor in an elderly man.

Editorial 
Mark J. Alberts, MD; Ty Shang, MD, PhD; Alejandro Magadan, MD

Patients with an occlusion of the distal internal carotid or proximal middle cerebral artery have among the most severe types of ischemic stroke that typically produce life-altering disabilities. Prior to a few months ago, the standard of care for such patients included intravenous (IV) alteplase and comprehensive peristroke ...

Editorial 
Elaine R. Peskind, MD; Brian Kraemer, PhD; Jing Zhang, MD, PhD

The search for plasma biomarkers of mild traumatic brain injury (mTBI) remains intense. The US Department of Defense and US Department of Veterans Affairs have invested more than $100 million toward this effort and the General Electric National Football League Challenge award made to Quanterix and Banyan Biomarkers ...

Original Investigation 
Anlys Olivera, PhD; Natasha Lejbman, BS; Andreas Jeromin, PhD; Louis M. French, PsyD; Hyung-Suk Kim, PhD; Ann Cashion, PhD; Vincent Mysliwiec, MD; Ramon Diaz-Arrastia, MD, PhD; Jessica Gill, RN, PhD

Importance  Approximately one-third of military personnel who deploy for combat operations sustain 1 or more traumatic brain injuries (TBIs), which increases the risk for chronic symptoms of postconcussive disorder, posttraumatic stress disorder, and depression and for the development of chronic traumatic encephalopathy. Elevated concentrations of tau are ...

Editorial: Biofluid Biomarkers of Mild Traumatic Brain Injury; Elaine R. Peskind, MD; Brian Kraemer, PhD; Jing Zhang, MD, PhD
Clinical Implications of Basic Neuroscience Research  FREE
Joseph M. Castellano, PhD; Elizabeth D. Kirby, PhD; Tony Wyss-Coray, PhD

In the modern medical era, more diverse and effective treatment options have translated to increased life expectancy. With this increased life span comes increased age-associated disease and the dire need to understand underlying causes so that therapies can be designed to mitigate the burden to health and the ...

Original Investigation 
Auriel A. Willette, PhD; Barbara B. Bendlin, PhD; Erika J. Starks, BS; Alex C. Birdsill, PhD; Sterling C. Johnson, PhD; Bradley T. Christian, PhD; Ozioma C. Okonkwo, PhD; Asenath La Rue, PhD; Bruce P. Hermann, PhD; Rebecca L. Koscik, PhD; Erin M. Jonaitis, PhD; Mark A. Sager, MD; Sanjay Asthana, MD
Includes: Supplemental Content

Importance  Converging evidence suggests that Alzheimer disease (AD) involves insulin signaling impairment. Patients with AD and individuals at risk for AD show reduced glucose metabolism, as indexed by fludeoxyglucose F 18–labeled positron emission tomography (FDG-PET).

Objectives  To determine whether insulin resistance predicts AD-like global and regional ...

Original Investigation 
Joseph H. Lee, DrPH; Rong Cheng, PhD; Badri Vardarajan, PhD; Rafael Lantigua, MD; Dolly Reyes-Dumeyer, BS; Ward Ortmann, PhD; Robert R. Graham, PhD; Tushar Bhangale, PhD; Timothy W. Behrens, MD; Martin Medrano, MD; Ivonne Z. Jiménez-Velázquez, MD; Richard Mayeux, MD, MSc
Includes: Supplemental Content

Importance  The present study identified potential genetic modifiers that may delay or accelerate age at onset of familial Alzheimer disease (AD) by examining age at onset in PSEN1 mutation carrier families, and further investigation of these modifiers may provide insight into the pathobiology of AD and potential ...

Clinical Pathologic Conference 
Kathleen E. McKee, MD; Mark R. Etherton, MD, PhD; Scott B. Lovitch, MD, PhD; Anoopum S. Gupta, MD, PhD; Douglas S. Micalizzi, MD, PhD; Travis Tierney, MD, PhD; Martha Wadleigh, MD; Henrikas Vaitkevicus, MD

A man in his 40s presented with 1 month of worsening confusion, fatigue, and headache. Results from laboratory analyses were notable for a complete white blood cell count of 17 000/μL (31% blast cells), a platelet count of 76 000/μL, and a hemoglobin level of 16.6 g/dL. Imaging studies revealed ...

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