The impact of betaine treatment on outcome in patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency is presently unclear.
To investigate the effect of betaine treatment on development and survival in patients with severe MTHFR deficiency.
MEDLINE, EMBASE, and Cochrane databases between ...
JAMA Neurol. Published online December 09, 2013. doi:10.1001/jamaneurol.2013.4915