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 Showing 1-20 of 66 Articles
Editorial 
Honglei Chen, MD, PhD

Parkinson disease (PD) is a slowly progressing neurodegenerative disease that primarily affects older adults. It rarely occurs before age 60 years and is more common in men, with a male to female ratio of approximately 1.5. The disease may have a decades-long prodromal stage before it can be clinically diagnosed. ...

Mitochondrial diseases are a group of heterogeneous disorders caused by inherited mutations in the mitochondrial genome (mtDNA) and nuclear genome. Typically, mutations in the mtDNA are maternally inherited and cause respiratory chain defects and account for a substantial fraction of childhood and adult neurometabolic disease, with an estimated ...

Editorial 
Louis R. Caplan, MD

One early and dramatic clinical account of hematoma expansion concerns a man who developed a hematoma that evolved under observation in 1937.1 He was sent to the hospital because of “malignant hypertension.” While his medical history was being taken, the patient complained of weakness, dizziness, and numbness ...

Original Investigation 
Kengo Maeda, PhD, MD; Hiromichi Kawai, PhD, MD; Mitsuru Sanada, PhD, MD; Tomoya Terashima, PhD, MD; Nobuhiro Ogawa, PhD, MD; Ryo Idehara, MD; Tetsuya Makiishi, PhD, MD; Hitoshi Yasuda, PhD, MD; Shun-ichi Sato, PhD, MD; Ken-ichi Hoshi, PhD, MD; Hiroyuki Yahikozawa, PhD, MD; Katsuji Nishi, PhD, MD; Yasushi Itoh, PhD, MD; Kazumasa Ogasawara, PhD, MD; Kazuo Tomita, PhD; Hiroko P. Indo, DDS, PhD; Hideyuki J. Majima, DDS, PhD

Importance  The regulatory factors explaining the wide spectrum of clinical phenotypes for mitochondrial 3243A>G mutation are not known. Crosstalk between nuclear genes and mitochondrial DNA might be one factor.

Observations  In this case series, we compared 2 pairs of male twins with the mitochondrial 3243 A>G ...

Editorial: Phenotypic Destiny in Mitochondrial Disease?; Martin Picard, PhD; Michio Hirano, MD
Original Investigation 
Rodolfo Savica, MD, MSc, PhD; Brandon R. Grossardt, MS; James H. Bower, MD, MSc; J. Eric Ahlskog, PhD, MD; Walter A. Rocca, MD, MPH

Importance  Changes over time in the incidence of parkinsonism and Parkinson disease (PD) remain uncertain.

Objective  To investigate secular trends (period effects) and birth cohort trends in the incidence of parkinsonism and PD over 30 years in a geographically defined American population.

Design, Setting, and Participants...

Editorial: Potential Increase in Parkinson Incidence ; Honglei Chen, MD, PhD
Original Investigation  FREE
Gregoire Boulouis, MD, MSc; Andrea Morotti, MD; H. Bart Brouwers, MD, PhD; Andreas Charidimou, MD, PhD; Michael J. Jessel, BS; Eitan Auriel, MD; Octávio Pontes-Neto, MD, PhD; Alison Ayres, BA; Anastasia Vashkevich, BA; Kristin M. Schwab, BA; Jonathan Rosand, MD, MSc; Anand Viswanathan, MD, PhD; Mahmut E. Gurol, MD, MSc; Steven M. Greenberg, MD, PhD; Joshua N. Goldstein, MD, PhD
Includes: Supplemental Content

Importance  Hematoma expansion is a potentially modifiable predictor of poor outcome following an acute intracerebral hemorrhage (ICH). The ability to identify patients with ICH who are likeliest to experience hematoma expansion and therefore likeliest to benefit from expansion-targeted treatments remains an unmet need. Hypodensities within an ICH ...

Images in Neurology 
Salman Farooq, MD; Bradley C. Hiner, MD; William J. Rhead, MD, PhD; Alison La Pean Kirschner, MS, CGC; Thomas C. Chelimsky, MD

This case report describes a woman in her 40s who developed pulvinar hyperintensity through pseudo-α-galactosidase deficiency syndrome.

Comment & Response 
David Louis Keller, MD

To the Editor Dietary aluminum ingestion is theorized to be neurotoxic and play a causative role in the onset and progression of dementia.13 A recent meta-analysis showed that individuals chronically exposed to aluminum were 71% more likely to develop Alzheimer disease (odds ratio, 1.71; 95% ...

Comment & Response 
Tomoyuki Kawada, MD

To the Editor I read with interest the article by Gomm and colleagues,1 which examined the association between the use of proton pump inhibitors (PPIs) and incident dementia in elderly individuals in a prospective study. The authors adopted time-dependent Cox regression analysis, and the time-dependent covariates were ...

Comment & Response 
Willy Gomm, PhD; Britta Haenisch, PhD

In Reply First, we thank the authors of the letters for their interest and comments concerning our article.1

Comment & Response 
Helge L. Waldum, MD, PhD; Tom Christian Martinsen, MD, PhD

To the Editor We read with interest the article by Gomm and colleagues1 on an association between proton pump inhibitors and dementia. Concerning a possible mechanism, we would like to focus on our 2 previous studies showing that acidic gastric juice protected mice against prion infection.2...

Comment & Response 
Jineane V. Venci, PharmD, BCACP; Katherine W. Eisenberg, MD, PhD

To the Editor In their recent publication, Gomm et al1 found that regular proton pump inhibitor (PPI) use was associated with a 44% increased risk for dementia based on claims data from a large German health insurer. The authors concluded that avoidance of PPI use may prevent ...

Comment & Response 
William D. Freeman, MD

To the Editor I read with interest the article by Gomm et al1 investigating the association of proton pump inhibitors and dementia. The authors are to be commended for their large data set, analysis, and detailed proposed pathophysiologic mechanism by which this association might occur. However, 2 ...

Comment & Response 
Kanika Sharma, MD; Alireza Minagar, MD; Hai Sun, MD, PhD

To the Editor Gomm and colleagues1 examine the association of proton pump inhibitor (PPI) use with the risk for incidental dementia in the elderly population. Using longitudinal data derived from the Allgemeine Ortskrankenkassen database, the largest German health insurer, the authors conclude that patients receiving regular PPIs ...

Comment & Response 
Long Nguyen, MD, MS; Chin Hur, MD, MPH

To the Editor We read the article by Gomm et al1 with great interest as the long-term safety with prolonged proton pump inhibitor (PPI) use is of significant concern for both health care prescribers and patients. The investigators analyzed a prospective observational cohort of patients derived from ...

Editorial 
Babu G. Welch, MD; H. Hunt Batjer, MD

The evolution of the treatment of intracranial aneurysms has been fascinating to observe. Since the clipping of intracranial aneurysms began with Dr Walter Dandy in 1933, innovations in the intraoperative and postoperative management of aneurysms have made it possible for these lesions to be treated, rather than being ...

Editorial 
Michael K. Racke, MD; Jaime Imitola, MD

Multiple sclerosis (MS) has been characterized clinically as a disorder manifested by multiple episodes of neurologic dysfunction separated in space and time. Guidelines have been developed that use imaging and the revised McDonald Criteria for the diagnosis of MS.1 Magnetic resonance imaging (MRI) has been a useful ...

Editorial 
Rebecca F. Gottesman, MD, PhD

As acute management of intracerebral hemorrhage (ICH) has improved, more patients survive ICH but are left with significant deficits. In the past, primary evaluations of outcomes after ICH have focused on mortality1 and levels of functional dependence,2 with a relatively modest number of patients experiencing true ...

Original Investigation 
Alessandro Biffi, MD; Destiny Bailey, BS; Christopher D. Anderson, MD, MMSc; Alison M. Ayres, BA; Edip M. Gurol, MD; Steven M. Greenberg, MD, PhD; Jonathan Rosand, MD, MSc; Anand Viswanathan, MD, PhD
Includes: Supplemental Content

Importance  Patients who have experienced intracerebral hemorrhage (ICH) appear to develop cognitive impairment at high rates, both early after ICH and over the long term.

Objective  To identify and compare risk factors for early and delayed dementia after ICH.

Design, Setting, and Participants  A longitudinal ...

Editorial: Dementia After Intracerebral Hemorrhage; Rebecca F. Gottesman, MD, PhD
Original Investigation 
Allan MacKenzie-Graham, PhD; Florian Kurth, MD, PhD; Yuichiro Itoh, PhD; He-Jing Wang, MD; Michael J. Montag, MS; Robert Elashoff, PhD; Rhonda R. Voskuhl, MD

Importance  Multiple sclerosis (MS) is characterized by progressive gray matter (GM) atrophy that strongly correlates with clinical disability. However, whether localized GM atrophy correlates with specific disabilities in patients with MS remains unknown.

Objective  To understand the association between localized GM atrophy and clinical disability in ...

Editorial: Cortical Volume Loss and Neurologic Dysfunction in Multiple Sclerosis; Michael K. Racke, MD; Jaime Imitola, MD

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