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Published monthly, JAMA Neurology brings you an international perspective on a wide range of topics from the leading centers of neurological research. Subscribe/Learn More

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Angiotensin-Converting Enzyme Inhibitors and Amyotrophic Lateral Sclerosis Risk. Lin et al.

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Dementia Risk After Traumatic Brain Injury vs Nonbrain Trauma: The Role of Age and Severity. Gardner et al.

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Absence of Disease Activity in Patients With Multiple Sclerosis

This cohort study characterizes how frequently patients with multiple sclerosis demonstrate no evidence of disease activity over 7 years of follow-up.

Rarity of Alzheimer Disease–Protective APP A673T Variant

This case-control study examines the frequency of the A673T variant in the amyloid precursor protein gene (APP) in the United States and Sweden to determine whether it will contribute to risk assessment for Alzheimer disease.

Spinal Cord Injury

This brief review describes the beneficial functions of endogenous neural stem cells after spinal cord injury.

Isolated Optic Neuritis

This case-control study of isolated optic neuritis (ON) finds that nearly half of patients with ON had antibodies to aquaporin 4, myelin-oligodendrocyte glycoprotein, and/or the 1 subunit of the glycine receptor.

Dopaminergic Deficits in Parkinson Disease

This cross-sectional study used PET measures of neurotransmitter levels to assess associations between dopaminergic and cholinergic denervation and cognitive impairment in nondemented patients with Parkinson disease.

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Author Interview

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Interview with Howard L. Weiner, MD, author of Evaluation of No Evidence of Disease Activity in a 7-Year Longitudinal Multiple Sclerosis Cohort, and Michael K. Racke, MD, author of Is No Evidence of Disease Activity a Realistic Goal for Patients With Multiple Sclerosis?

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Evaluation of No Evidence of Disease Activity in a 7-Year Longitudinal Multiple Sclerosis Cohort

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Hemidystonia (01:59)

The patient has dystonic posturing of her left hand and left foot.


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What is your diagnosis?

A 48-year-old woman was brought to the local hospital emergency department because of a month-long history of increasing depression, insomnia, anorexia, and weight loss and a 2-week lack of speech communication.

What is your diagnosis?

Call for Papers

JAMA Neurology is announcing a new journal feature, Clinical Challenge, which will be published quarterly, under the section editorship of Lawrence S. Honig, MD, PhD. The goal of this feature is to present short clinical problems to challenge readers to arrive at the correct diagnosis from a small data set, including images. Readers will see a short clinical synopsis and relevant images or laboratory information allowing them to exercise their diagnostic skills. Actual correct diagnosis and a brief discussion will be available on the following page of the journal or on the Discussion tab online. The overall format of this feature will be like that of the current highly successful feature What is Your Diagnosis?, which has been running since January 2011, available on the web quarterly, only online. Clinical Challenge will be the successor to this feature but will be an integral journal section, viewable interactively online and in the print version of the journal, and indexed like other articles. JAMA Neurology welcomes submissions to this feature, for which any submission should include a maximum of up to 3 authors. The format must include (1) a paragraph introducing and describing the clinical case (no more than 250 words); (2) 1 to 3 figures including imaging, electrophysiological, and/or other laboratory data; (3) 4 multiple-choice potential answers for diagnosis; and (4) a paragraph of discussion (no more than 600 words) disclosing the actual diagnosis (confirmed by conclusive tissue pathology, genetic, or other test), and including up to 10 references. We invite submissions through the standard JAMA Neurology submissions process.

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Introducing JAMA Network Author Video Interviews

Author Saurav Chatterjee, MD, discusses Oral Anticoagulants and Intracranial Hemorrhage.

Author Lorina Naci, PhD, discusses Making Every Word Count for Nonresponsive Patients.

Author Gil Rabinovici, MD, discusses Progranulin Mutations as Risk Factors for Alzheimer Disease.

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