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Original Investigation | October 5, 2015 ONLINE FIRST

Whole-Exome Sequencing for Diagnosis of Limb-Girdle Muscular Dystrophy

This study translates whole-exome sequencing to clinical practice for the genetic diagnosis of a large cohort of patients with limb-girdle muscular dystrophy for whom protein-based analyses and targeted Sanger sequencing failed to identify the genetic cause of their disorder.

Original Investigation | October 5, 2015 FREE ONLINE FIRST

β-Amyloidosis and Neurodegeneration in Mild Cognitive Impairment

This longitudinal, observational study with serial brain imaging aimed to define the role of β-amyloidosis and neurodegeneration in the subsequent progression of topographic cortical structural and metabolic changes in mild cognitive impairment.

Review | October 5, 2015 ONLINE FIRST

Importance of Rare Subtypes in Peripheral Neuropathy

This review article describes rare localizations of peripheral neuropathy, including the appropriate diagnostic evaluation and available treatments.

Original Investigation | September 28, 2015 FREE ONLINE FIRST

Autoimmune Cerebellar Ataxia Accompanying Neural Antibodies in Adults

This case series from the Mayo Clinic describes treatment responses and outcomes of adults with autoimmune cerebellar ataxia.

Original Investigation | September 28, 2015 ONLINE FIRST

Long-term Cardiac Outcome and Survival Predictors in Friedreich Ataxia

This cohort study characterizes cardiac outcomes and survival in 138 patients with genetically confirmed Friedreich ataxia.

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Author Interview

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Interview with Joshua W. Miller, PhD, author of Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults

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Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults

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Patient Before and After Deep Brain Stimulation (02:35)

A, Patient before deep brain stimulation. B, Patient 2 months after deep brain stimulation.

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Latest Quiz

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Personality Change and Gait Dysfunction

A woman in her 50s was referred to a neurologist for a history of gait, balance, personality, and judgment changes over 4 years.

What is your diagnosis?

American Neurological Association Satellite Symposium

The American Neurological Association is having a satellite symposium “Circuits and Circuit Disorders: Approaches to Neuromodulation,” Saturday, September 26, 2015, 7:00 pm, Marriott Downtown Hotel, Chicago, Illinois, the evening before the start of the annual meeting. It is cosponsored by the Annals of Neurology and JAMA Neurology and features Mahlon Delong, MD, Emory University, 2014 Lasker Prize in Medicine recipient for his research in developing deep brain stimulation; Philip Starr, MD, PhD, University of California, San Francisco, the dystonias; Jonathan Mink, MD, PhD, University of Rochester Medical Center, Tourette syndrome; Helen Mayberg, MD, Emory University, depression; and Bryan L. Roth, PhD, University of North Carolina, chemogenetics.

Registration for the meeting and hotel accommodations can be obtained at http://myana.org/events/ana-2015-annual-meeting.

Annual Meeting: American Neurological Association

Announcing the American Neurological Association’s 140th annual meeting, Chicago, Illinois, September 27-29, 2015.

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