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Published monthly, JAMA Neurology brings you an international perspective on a wide range of topics from the leading centers of neurological research. Subscribe/Learn More

In the Media
Dementia Risk After Traumatic Brain Injury vs Nonbrain Trauma: The Role of Age and Severity. Gardner et al.

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Vaccines and the Risk of Multiple Sclerosis and Other Central Nervous System Demyelinating Diseases. Langer-Gould et al.

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Varicella-Zoster Virus Infections in Multiple Sclerosis

This analysis of fingolimod trial data compares incidence of VZV infections in patients assigned to fingolimod vs placebo.

Rasagiline and Antidepressants in Parkinson Disease

This post-hoc analysis of data from a trial of MOAO-B inhibition for patients with Parkinson disease reports that patients who used antidepressants with the study drug had reduced worsening of their nonmotor symptoms vs those who did not use antidepressants.

Outcomes for Patients Given Prehospital Thrombolysis Within One Hour

This post-hoc analysis of data from a mobile stroke unit trial reports improved time-to-thrombolysis and outcomes for patients assigned to prehospital care.

Cancer in Patients with LRRK2 G2019S Mutations and Parkinson Disease

This cross-sectional study reports an association between LRRK2 G2019S mutations and cancer among patients with Parkinson disease.

Axonal Ion Channel Dysfunction in Familial Amyotrophic Lateral Sclerosis

This cross-sectional study compared axonal channel dysfunction in patients with c9orf72 familial and sporadic amyotrophic lateral sclerosis.

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Author Interview

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Interview with Jerry S. Wolinsky, MD, author of Varicella-Zoster Virus Infections in Patients Treated With Fingolimod: Risk Assessment and Consensus Recommendations for Management, and Kenneth L. Tyler, MD, author of Fingolimod and Risk of Varicella-Zoster Virus Infection: Back to the Future With an Old Infection and a New Drug

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Varicella-Zoster Virus Infections in Patients Treated With Fingolimod:  Risk Assessment and Consensus Recommendations for Management

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Hemidystonia (01:59)

The patient has dystonic posturing of her left hand and left foot.


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What is your diagnosis?

A 48-year-old woman was brought to the local hospital emergency department because of a month-long history of increasing depression, insomnia, anorexia, and weight loss and a 2-week lack of speech communication.

What is your diagnosis?

Call for Papers

JAMA Neurology is announcing a new journal feature, Clinical Challenge, which will be published quarterly, under the section editorship of Lawrence S. Honig, MD, PhD. The goal of this feature is to present short clinical problems to challenge readers to arrive at the correct diagnosis from a small data set, including images. Readers will see a short clinical synopsis and relevant images or laboratory information allowing them to exercise their diagnostic skills. Actual correct diagnosis and a brief discussion will be available on the following page of the journal or on the Discussion tab online. The overall format of this feature will be like that of the current highly successful feature What is Your Diagnosis?, which has been running since January 2011, available on the web quarterly, only online. Clinical Challenge will be the successor to this feature but will be an integral journal section, viewable interactively online and in the print version of the journal, and indexed like other articles. JAMA Neurology welcomes submissions to this feature, for which any submission should include a maximum of up to 3 authors. The format must include (1) a paragraph introducing and describing the clinical case (no more than 250 words); (2) 1 to 3 figures including imaging, electrophysiological, and/or other laboratory data; (3) 4 multiple-choice potential answers for diagnosis; and (4) a paragraph of discussion (no more than 600 words) disclosing the actual diagnosis (confirmed by conclusive tissue pathology, genetic, or other test), and including up to 10 references. We invite submissions through the standard JAMA Neurology submissions process.

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Introducing JAMA Network Author Video Interviews

Author Saurav Chatterjee, MD, discusses Oral Anticoagulants and Intracranial Hemorrhage.

Author Lorina Naci, PhD, discusses Making Every Word Count for Nonresponsive Patients.

Author Gil Rabinovici, MD, discusses Progranulin Mutations as Risk Factors for Alzheimer Disease.

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