Published monthly, JAMA Neurology brings you an international perspective on a wide range of topics from the leading centers of neurological research.
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Mormino et al assess whether neuroimaging markers of β-amyloid and neurodegeneration are synergistically associated with longitudinal cognitive decline in clinically normal individuals.
This case report describes a patient with "ping-pong" eye movements and decerebrate rigidity due to an ischemic stroke in the midbrain.
Huh et al evaluate the efficacy and safety of mycophenolate mofetil treatment in patients with neuromyelitis optica spectrum disorder.
This GWAS study characterizes associations between known genetic risk loci for Alzheimer disease and age at onset.
George et al describe 2 patients with aquaporin-4 antibodies who experienced vision loss resulting from opportunistic infections during immunosuppressive therapy.
Interview with Shivanand P. Lad, MD, PhD, author of Effect of Advancing Age on Outcomes of Deep Brain Stimulation for Parkinson Disease
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Periodic alternating gaze (ping-pong gaze), with conjugate roving of the eyes from one extreme of horizontal gaze to the other, holding the extreme position for 2 to 3 seconds.
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A 48-year-old woman was brought to the local hospital emergency department because of a month-long history of increasing depression, insomnia, anorexia, and weight loss and a 2-week lack of speech communication.
What is your diagnosis?
Announcing the American Neurological Association annual meeting, Baltimore, Maryland, October 12-14, 2014
JAMA Neurology is announcing a new journal feature, Clinical Challenge, which will be published quarterly, under the section editorship of Lawrence S. Honig, MD, PhD. The goal of this feature is to present short clinical problems to challenge readers to arrive at the correct diagnosis from a small data set, including images. Readers will see a short clinical synopsis and relevant images or laboratory information allowing them to exercise their diagnostic skills. Actual correct diagnosis and a brief discussion will be available on the following page of the journal or on the Discussion tab online. The overall format of this feature will be like that of the current highly successful feature What is Your Diagnosis?, which has been running since January 2011, available on the web quarterly, only online. Clinical Challenge will be the successor to this feature but will be an integral journal section, viewable interactively online and in the print version of the journal, and indexed like other articles. JAMA Neurology welcomes submissions to this feature, for which any submission should include a maximum of up to 3 authors. The format must include (1) a paragraph introducing and describing the clinical case (no more than 250 words); (2) 1 to 3 figures including imaging, electrophysiological, and/or other laboratory data; (3) 4 multiple-choice potential answers for diagnosis; and (4) a paragraph of discussion (no more than 600 words) disclosing the actual diagnosis (confirmed by conclusive tissue pathology, genetic, or other test), and including up to 10 references. We invite submissions through the standard JAMA Neurology submissions process.
International translations of Author Video Interviews
Author Saurav Chatterjee, MD, discusses Oral Anticoagulants and Intracranial Hemorrhage.
Author Lorina Naci, PhD, discusses Making Every Word Count for Nonresponsive Patients.
Author Gil Rabinovici, MD, discusses Progranulin Mutations as Risk Factors for Alzheimer Disease.
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