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Published monthly, JAMA Neurology brings you an international perspective on a wide range of topics from the leading centers of neurological research. Subscribe/Learn More

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Original Investigation | August 24, 2015 FREE ONLINE FIRST

Nerve Growth Factor Gene Therapy

This postmortem pathology study characterizes neuronal responses of patients with early Alzheimer disease who underwent nerve growth factor gene therapy delivered after disease onset.

Original Investigation | August 17, 2015 ONLINE FIRST

Encephalitis Associated With Antibodies Against the AMPA Receptor

This case series describes 7 patients with autoimmune encephalitis attributable to antibodies against the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR-Abs).

Original Investigation | August 10, 2015 ONLINE FIRST

CSF Patterns and Risk of Future Dementia in Early, Incident PD

This cohort study of patients with idiopathic parkinsonism assesses the diagnostic and prognostic accuracy of cerebrospinal fluid biomarkers in patients with early Parkinson disease and related disorders.

Clinical Implications of Basic Neuroscience Research | August 3, 2015 ONLINE FIRST

Blood-Borne Revitalization of the Aged Brain

This review summarizes evidence from animal model studies that blood from younger animals can rejuvenate cellular elements of the central nervous system, and discusses potential therapeutic implications of the findings.

Original Investigation | July 27, 2015 ONLINE FIRST

Insulin Resistance and Cerebral Glucose Uptake in Alzheimer Disease

This cross-sectional study measures associations between insulin resistance, PET-measured regional cerebral glucose metabolism, and neuropsychological measures in cognitively normal, late middle–aged adults at risk for Alzheimer disease.

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Author Interview

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Interview with Thomas F. McElrath, MD, PhD, author of Mortality and Morbidity During Delivery Hospitalization Among Pregnant Women With Epilepsy in the United States, and Jacqueline A. French, MD, author of Risks of Epilepsy During Pregnancy: How Much Do We Really Know?

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Mortality and Morbidity During Delivery Hospitalization Among Pregnant Women With Epilepsy in the United States

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Progressive Ataxia and Palatal Tremor (01:00)

The patient was unable to stop myoclonus of the palate with voluntary use of the palatal musculature.


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Personality Change and Gait Dysfunction

A woman in her 50s was referred to a neurologist for a history of gait, balance, personality, and judgment changes over 4 years.

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American Neurological Association Satellite Symposium

The American Neurological Association is having a satellite symposium “Circuits and Circuit Disorders: Approaches to Neuromodulation,” Saturday, September 26, 2015, 7:00 pm, Marriott Downtown Hotel, Chicago, Illinois, the evening before the start of the annual meeting. It is cosponsored by the Annals of Neurology and JAMA Neurology and features Mahlon Delong, MD, Emory University, 2014 Lasker Prize in Medicine recipient for his research in developing deep brain stimulation; Philip Starr, MD, PhD, University of California, San Francisco, the dystonias; Jonathan Mink, MD, PhD, University of Rochester Medical Center, Tourette syndrome; Helen Mayberg, MD, Emory University, depression; and Bryan L. Roth, PhD, University of North Carolina, chemogenetics.

Registration for the meeting and hotel accommodations can be obtained at http://myana.org/events/ana-2015-annual-meeting.

Annual Meeting: American Neurological Association

Announcing the American Neurological Association’s 140th annual meeting, Chicago, Illinois, September 27-29, 2015.

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