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To determine if patients having PD with vs without GBA mutations differ in clinical phenotype or plasma protein expression, Chahine et al performed a casecontrol study. Clinical characteristics were compared between groups, and biochemical profiling of 40 plasma proteins was performed to identify proteins that differed in expression between groups.
Angus-Leppan et al illustrate potential difficulties in differentiating autoimmune encephalopathies from sporadic Creutzfeldt-Jakob disease.
In a retrospective cohort study, Rangaraju and coauthors assess whether patients with intracranial large-vessel occlusions who received intra-arterial therapy have smaller final infarct volumes than patients who received either intravenous tissue plasminogen activator therapy or no reperfusion therapy. See the editorial by Adams and Froehler.
Alloush and Weisleder reviewed the literature on membrane repair in the past decade, considering recent discoveries of genes associated with the membrane repair process in skeletal muscle and the implications for treatment of muscular dystrophy.
Vissing et al evaluate the use of muscle biopsy vs blood-based enzymatic assays in the diagnosis of late-onset Pompe disease.
Interview with Rishi Gupta, MD, author of Comparison of Final Infarct Volumes in Patients Who Received Endovascular Therapy or Intravenous Thrombolysis for Acute Intracranial Large-Vessel Occlusions
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Corneomandibular Reflex in Coma
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A 65-year-old man presented to his local emergency department after noticing that he was staggering and had slurred speech for much of the day.
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Announcing the American Neurological Association annual meeting, New Orleans, Louisiana, October 13-15, 2013.
Author Gil Rabinovici, MD, discusses Progranulin Mutations as Risk Factors for Alzheimer Disease
Author Bruce R. Reed, PhD, discusses The Aging Brain and Cognition: Contribution of Vascular Injury and Aβ to Mild Cognitive Dysfunction
A discussion with Drs. Atul Gawande and Uwe Reinhardt about health care reform in the U.S.
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