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May 2012
Vol 69, No. 5

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Published monthly, Archives of Neurology brings you an international perspective on a wide range of topics from the leading centers of neurological research. Subscribe/Learn More

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Observation | May 14, 2012

A Novel Mutation in PNPLA2 Leading to Neutral Lipid Storage Disease With MyopathyMutation in PNPLA2 Leading to NLSD With Myopathy

Ash and coauthors report the clinical and molecular features of a case of neutral lipid storage disease with myopathy resulting from a novel mutation in PNPLA2.
Original Contribution | May 14, 2012

Frontotemporal Dementia in a Brazilian Kindred With the C9orf72 MutationFrontotemporal Dementia and C9orf72 Mutation

Takada et al describe the clinical features of a Brazilian kindred with C9orf72 frontotemporal dementia–amyotrophic lateral sclerosis and compare them with other described families with C9orf72 and frontotemporal dementia–amyotrophic lateral sclerosis–causing mutations.
Original Contributions | May 7, 2012

Increased Cerebral Metabolism After 1 Year of Deep Brain Stimulation in Alzheimer DiseaseIncreased Cerebral Metabolism After 1 Year of DBS

Smith and coauthors used an open-label trial to test the hypotheses that deep brain stimulation would increase cerebral glucose metabolism in cortical and hippocampal circuits and that increased metabolism would be correlated with better clinical outcomes.
Original Contribution | May 7, 2012

Cellular Immune Suppression in Paraneoplastic Neurologic Syndromes Targeting Intracellular AntigensCellular Immune Suppression in PNDs

Orange and colleagues conducted a retrospective case series of 26 patients with paraneoplastic neurologic disorders (PNDs) to evaluate the short-term use of a combination of prednisone and tacrolimus for acute neurologic worsening in PND in which intracellular antigens are targeted.

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Interview with Leonel T. Takada, MD, author of Frontotemporal Dementia in a Brazilian Kindred With the C9orf72 Mutation.

Frontotemporal Dementia in a Brazilian Kindred With the C9orf72 MutationFrontotemporal Dementia and C9orf72 Mutation

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Painful Legs and Moving Toes Syndrome (01:00)

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Predictors of Survival in Patients With Parkinson Disease

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What is your diagnosis?

A 40-year-old right-handed man previously functioning well at a high-level occupation presented with a 2-year history of increasing drug and alcohol abuse leading to attendance at multiple rehabilitation programs, which, however, was unsuccessful.

What is your diagnosis?

Call for Papers

Archives of Neurology will publish a special theme issue in March 2013 on Genomics/Genetics and Epigenetics. We invite the submission of papers as Neurological Reviews, Clinical Trials, Original Contributions, Case Reports, Images in Neurology, and Research Letters. Papers submitted by September 1, 2012, will have the best opportunity to be considered for this theme issue.

Take a video tour and read the JAMA editorial about the all-new jamanetwork.com.

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Alzheimer's Association International Conference

Announcing the Alzheimer's Association International Conference, Vancouver, BC, Canada, July 4-19, 2012

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Latest Content Highlights

A Novel Mutation in PNPLA2 Leading to Neutral Lipid Storage Disease With MyopathyMutation in PNPLA2 Leading to NLSD With Myopathy

Frontotemporal Dementia in a Brazilian Kindred With the C9orf72 MutationFrontotemporal Dementia and C9orf72 Mutation

Increased Cerebral Metabolism After 1 Year of Deep Brain Stimulation in Alzheimer DiseaseIncreased Cerebral Metabolism After 1 Year of DBS

Cellular Immune Suppression in Paraneoplastic Neurologic Syndromes Targeting Intracellular AntigensCellular Immune Suppression in PNDs

Multimedia >

Frontotemporal Dementia in a Brazilian Kindred With the C9orf72 MutationFrontotemporal Dementia and C9orf72 Mutation

CME >

Predictors of Survival in Patients With Parkinson Disease

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Alzheimer's Association International Conference

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