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Krogias et al describe a patient with a Caspr2 autoantibodies–associated syndrome who had an unusual clinical triad of epilepsy, dysarthria, and paroxysmal kinesigenic dystonia and an excellent response to B-cell–anergizing therapy using the humanized monoclonal antibody tocilizumab directed against the interleukin 6 receptor.
Haight et al examine cerebrovascular disease and AD markers in relation to brain glucose metabolism in patients with mild cognitive impairment in a cohort study among the Alzheimer Disease Neuroimaging Initiative clinical sites in the United States and Canada. Two hundred three patients with serial imaging were studied during a 3-year follow-up period.
Hanson et al characterize the lipidation states of β-amyloid peptides and apolipoprotein E in the cerebrospinal fluid in adults with respect to cognitive diagnosis and APOE ε4 allele carrier status at baseline and after a dietary intervention. See the editorial by Blacker.
Wang and coauthors examine the associations of CGG repeat and FMR1 mRNA with motor-related fiber tracts in males with premutation alleles.
Alkawadri and colleagues studied 14 consecutive cingulate gyrus epilepsy cases identified retrospectively to characterize the clinical and electrophysiological findings of epilepsies arising from the anterior and posterior cingulate gyrus.
Interview with Rafeed Alkawadri, MD, author of Cingulate Epilepsy: Report of 3 Electroclinical Subtypes With Surgical Outcomes
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Demonstration of Kinesigenic Dyskinesia
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A 65-year-old man presented to his local emergency department after noticing that he was staggering and had slurred speech for much of the day.
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Announcing the American Neurological Association annual meeting, New Orleans, Louisiana, October 13-15, 2013.
Author Gil Rabinovici, MD, discusses Progranulin Mutations as Risk Factors for Alzheimer Disease
Author Bruce R. Reed, PhD, discusses The Aging Brain and Cognition: Contribution of Vascular Injury and Aβ to Mild Cognitive Dysfunction
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