TY  - JOUR
T1  - Optical coherence tomography in clinically isolated syndrome: No evidence of subclinical retinal axonal loss
AU  - Outteryck O, Zephir H, Defoort S, et al
Y1  - 2009/11/01
N1  - 10.1001/archneurol.2009.265
JO  - Archives of Neurology
SP  - 1373
EP  - 1377
VL  - 66
IS  - 11
N2  - Background 
    Optical coherence tomography has emerged as a new tool for quantifying axonal loss in multiple sclerosis (MS). A reduction in retinal nerve fiber layer (RNFL) thickness is correlated with Expanded Disability Status Scale score and brain atrophy.Objective 
    To investigate RNFL and macular volume measurements using optical coherence tomography in the clinically isolated syndrome population.Design 
    Prospective case series.Settings 
    Neurologic clinics at the university hospitals of Lille and Strasbourg (France).Participants 
    Fifty-six consecutive patients with clinically isolated syndrome (18 with optic neuritis and 38 without optic neuritis) and 32 control subjects.Main Outcome Measures 
    Macular volume and RNFL thickness.Results 
    Mean (SD) overall RNFL thickness (98.98 [10.26] μm) and macular volume (6.86 [0.32] μm3) in the clinically isolated syndrome population were not significantly different compared with the controls (98.71 [9.08] μm and 6.92 [0.38] μm3, respectively). No link was noted between atrophy of the RNFL or macula and conversion to MS at 6 months.Conclusions 
    Optical coherence tomography does not reveal retinal axonal loss at the earliest clinical stage of MS and does not predict conversion to MS at 6 months.
SN  - 0003-9942
M3  - doi: 10.1001/archneurol.2009.265
UR  - http://dx.doi.org/10.1001/archneurol.2009.265
ER  -