TY  - JOUR
T1  - PRogressive ataxia and palatal tremor
AU  - Brinar VV, Barun B, Zadro I, Ozretić D, Habek M
Y1  - 2008/09/01
N1  - 10.1001/archneur.65.9.1248
JO  - Archives of Neurology
SP  - 1248
EP  - 1249
VL  - 65
IS  - 9
N2  - 
On admission, the patient had severe palatal tremor (a video is available here) with Romberg and walking instability. She had no signs of pyramidal or sensory involvement and cognitive examination results were normal. Magnetic resonance imaging (3-T) was performed and revealed atrophy of the vermis and both cerebellar hemispheres and bilateral symmetrical hyperintensity of olivary nuclei (Figure). Brain single-photon emission computed tomographic results were normal. Results of standard laboratory tests (sedimentation rate, complete blood count, serum glucose, electrolytes, liver enzymes, urea, creatinine, creatine kinase, lactate dehydrogenase, and C-reactive protein) were within normal limits. Serum and urine copper and ceruloplasmin levels were also normal. Results of genetic analysis for spinocerebellar ataxias 1, 2, 3, and 6; fragile X–associated tremor; ataxia syndrome; and Huntington disease were negative. Cerebrospinal fluid analysis revealed 1 lymphocyte and a slightly elevated protein level (0.062 g/dL [to convert to grams per liter, multiply by 10.0]) with negative oligoclonal bands.

SN  - 0003-9942
M3  - doi: 10.1001/archneur.65.9.1248
UR  - http://dx.doi.org/10.1001/archneur.65.9.1248
ER  -