TY  - JOUR
T1  - Chronic relapsing experimental allergic encephalomyelitis: Immunohistochemical studies
AU  - Grundke-Iqbal I, Lassmann H, Wisniewski HM
Y1  - 1980/10/01
N1  - 10.1001/archneur.1980.00500590075013
JO  - Archives of Neurology
SP  - 651
EP  - 656
VL  - 37
IS  - 10
N2  - • The immunohistochemical staining of immunoglobulins (Ig), complement (C3), and fibrinogen in chronic relapsing experimental allergic encephalomyelitis lesions showed different staining patterns in the acute vs the chronic stage of the disease. In the acute stage, Ig, C3, and fibrinogen were present in the perivascular tissue of the brain and the spinal cord. In hyperacute-type lesions, the binding of Ig and C3 to the parenchyma was especially pronounced. The chronic stage of the disease was characterized by lg-containing cells and Ig binding to white matter in actively demyelinating lesions. Linear or granular deposits of immunoglobulin and complement, reminiscent of those described in immune complex disease, were found in the choroid plexus.
SN  - 0003-9942
M3  - doi: 10.1001/archneur.1980.00500590075013
UR  - http://dx.doi.org/10.1001/archneur.1980.00500590075013
ER  -