TY  - JOUR
T1  - MIconazole therapy for fungal meningitis
AU  - Sung JP, Campbell GD, Grendahl JG
Y1  - 1978/07/01
N1  - 10.1001/archneur.1978.00500310045009
JO  - Archives of Neurology
SP  - 443
EP  - 447
VL  - 35
IS  - 7
N2  - • Eight patients with fungal meningitis (5 with the coccidioidal type, 2 with cryptococcal, and 1 with histoplasmosis) were treated with intravenous (IV) and intrathecal (IT) miconazole after previous therapy with amphotericin B proved unsuccessful.Miconazole was well tolerated with both IV and IT administration. The CSF concentration of miconazole one hour after an IV infusion of 800 mg was 0.1 to 0.3 μ/ml. When 20 mg of miconazole was administered intrathecally via lumbar injection in patients with coccidioidal meningitis, 6.5, 2.4, 0.77, and 0.24 μg/ml, respectively, was found in the CSF at the cisternal level at 12, 24, 48, and 72 hours, respectively.Miconazole is apparently an effective fungistatic drug of low toxicity and is a potentially useful agent in the treatment of systemic mycoses and fungal meningitis, in particular.
SN  - 0003-9942
M3  - doi: 10.1001/archneur.1978.00500310045009
UR  - http://dx.doi.org/10.1001/archneur.1978.00500310045009
ER  -