TY  - JOUR
T1  - Evidence of intrathecal immunoglobulin synthesis in stroke: A cohort study
AU  - Prüss H, Iggena D, Baldinger T, et al
Y1  - 2012/06/01
N1  - 10.1001/archneurol.2011.3252
JO  - Archives of Neurology
SP  - 714
EP  - 717
VL  - 69
IS  - 6
N2  - Background 
                  Immune mechanisms are included in stroke pathophysiologic factors, but the frequency and role of intrathecal antibodies is unclear and diagnostic tests are not routinely performed on cerebrospinal fluid (CSF).Objective 
                  To determine the frequency of intrathecal immunoglobulin synthesis in a well-characterized cohort of patients who experienced “noninflammatory” acute stroke.Design 
                  Retrospective cohort study.Setting 
                  University hospital neurology department.Patients 
                  Patients (n = 318) with stroke who were undergoing lumbar puncture during diagnostic workup and 79 control patients.Results 
                  Cerebrospinal fluid–specific immunoglobulin (IgG, IgM, and IgA) synthesis was significantly (P < .001) more frequent after stroke (24.8%) compared with the incidence in age- and sex-matched controls (2.5%). Furthermore, 31.3% of stroke patients demonstrated blood-brain barrier dysfunction and 18.1% displayed pleocytosis.Conclusion 
                  The strong association between CSF-specific immunoglobulin synthesis and stroke suggests a role in the development of cerebral ischemia and might constitute an immunologically defined stroke subgroup.
SN  - 0003-9942
M3  - doi: 10.1001/archneurol.2011.3252
UR  - http://dx.doi.org/10.1001/archneurol.2011.3252
ER  -