TY  - JOUR
T1  - ANti–myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis
AU  - Rostasy K, Mader S, Schanda K, et al
Y1  - 2012/06/01
N1  - 10.1001/archneurol.2011.2956
JO  - Archives of Neurology
SP  - 752
EP  - 756
VL  - 69
IS  - 6
N2  - Objective 
                  To study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG) in pediatric patients with isolated and recurrent optic neuritis (ON).Design 
                  Observational prospective case series.Setting 
                  Six pediatric hospitals in Germany and Austria.Patients 
                  Thirty-seven patients 18 years or younger with single or recurrent episodes of ON were recruited from 6 different hospitals.Main Outcome Measures 
                  Clinical features, magnetic resonance imaging findings, intrathecal IgG synthesis, and outcome were recorded. A live cell–based immunofluorescence assay was used to measure serum IgG antibodies to MOG and aquaporin 4.Results 
                  A single episode of ON was observed in 10 patients, and 15 experienced 2 to 12 episodes. The acute episode of ON was part of a clinically isolated syndrome in 12 patients, of whom 8 were subsequently classified as having multiple sclerosis. High-titer serum MOG-IgG antibodies (≥1:160) were detected in 17 patients (46%). In addition, high titers of MOG-IgG antibodies were more frequently observed in 12 of the 15 patients with recurrent episodes of ON (80%; median titer, 1:640) compared with 2 of the 10 patients with monophasic ON (20%; median titer, 0) and 3 of the 12 patients with ON as part of a clinically isolated syndrome (25%; median titer, 0).Conclusion 
                  High-titer MOG-IgG antibodies are predominantly detected in pediatric patients with recurrent ON, indicating that anti–MOG-specific antibodies may exert a direct role in the pathogenesis of ON in this subgroup.
SN  - 0003-9942
M3  - doi: 10.1001/archneurol.2011.2956
UR  - http://dx.doi.org/10.1001/archneurol.2011.2956
ER  -