RT Journal
A1 Stüve O, Wang J, Chan A, et al
T1 NO association between genetic polymorphism at codon 129 of the prion protein gene and primary progressive multiple sclerosis
JF Archives of Neurology
JO Archives of Neurology
YR 2011
FD February 1
VO 68
IS 2
SP 264
OP 271
DO 10.1001/archneurol.2010.354
UL http://dx.doi.org/10.1001/archneurol.2010.354
AB 
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. Approximately 10% to 20% of patients with MS are diagnosed with primary progressive MS (PPMS), defined as a disease course with gradual accumulation of disability without any clinical attacks or remission from onset.1 Primary progressive MS is considered by many to have more neurodegenerative characteristics than other MS phenotypes. In addition, and perhaps supportive of the notion that PPMS has a degenerative rather than an inflammatory pathogenesis, are that (1) immune therapies are ineffective, (2) the age at onset is typically around 40 years and thus significantly later than that of relapsing-remitting MS,2- 5 and (3) that there appears to be no sex predilection.3