RT Journal
A1 Manyam N, Katz L, Hare TA, Gerber JC, III, Grossman MH
T1 LEvels of γ-aminobutyric acid in cerebrospinal fluid in various neurologic disorders
JF Archives of Neurology
JO Archives of Neurology
YR 1980
FD June 1
VO 37
IS 6
SP 352
OP 355
DO 10.1001/archneur.1980.00500550054006
UL http://dx.doi.org/10.1001/archneur.1980.00500550054006
AB • Levels of γ-aminobutyric acid (GABA) in CSF were measured by the ion exchange-fluorometric method in 136 patients who underwent evaluation for neurologic disorders. In 19 patients with no organic neurologic or mental disorders who acted as normal controls, the mean ( ± SD) GABA level in CSF was 239 ± 76 picomoles/mL. Patients with acute hypoxic encephalopathy showed a mean GABA level in CSF higher than that of the controls, a difference that was statistically significant. In all the other disorders studied, the mean GABA level in CSF was either equal to or lower than that found in the controls. Statistically significant reductions of the GABA level in CSF were seen in patients with Huntington's disease, dementias, cerebellar cortical atrophy, multiple sclerosis, epilepsy, and Parkinson's disease.