RT Journal
A1 O'Brien MD, Jordan MM, Waltz AG
T1 Ischemic cerebral edema and the blood-brain barrier: Distributions of pertechnetate, albumin, sodium, and antipyrine in brains of cats after occlusion of the middle cerebral artery
JF Archives of Neurology
JO Archives of Neurology
YR 1974
FD June 1
VO 30
IS 6
SP 461
OP 465
DO 10.1001/archneur.1974.00490360037008
UL http://dx.doi.org/10.1001/archneur.1974.00490360037008
AB Distributions of pertechnetate, albumin, sodium, and antipyrine in cat brains were studied four hours to 20 days after occlusion of one middle cerebral artery (MCA). Brain:blood ratios for each substance were greatest in infarcted tissue and least in nonischemic tissue. Higher ratios for pertechnetate than for albumin in nonischemic tissue indicated a normal extravascular distribution of pertechnetate. In ischemic and infarcted tissue, brain:blood ratios for pertechnetate, albumin, and sodium were increased as early as four hours after MCA occlusion, were maximal at four to seven days, and remained high (for pertechnetate) until 20 days. Distributions of water after MCA occlusion did not have the same temporal or spatial characteristics as distributions of the other substances; thus, ischemic cerebral edema is not related solely to disruptions of the blood-brain barrier or to extravascular accumulations of sodium and protein.