RT Journal
A1 Korth C
T1 Identification of dominant human aquaporin 4 t-cell epitopes: Observations in neuromyelitis optica with implications for other autoimmune disorders
JF Archives of Neurology
JO Archives of Neurology
YR 2012
FD September 1
VO 69
IS 9
SP 1111
OP 1112
DO 10.1001/archneurol.2012.1561
UL http://dx.doi.org/10.1001/archneurol.2012.1561
AB 
Neuromyelitis optica (NMO), formerly known as Devic disease, is a relatively rare autoimmune disease of the central nervous system (CNS) clinically characterized by prominent, mostly relapsing-remitting symptoms that affect vision and loss of motoric, sensory, or autonomic functions.1 Current diagnostic criteria require the presence of optic neuritis, myelitis, and 2 of the following 3 criteria: (1) evidence of a contiguous spinal cord lesion of 3 or more segments in length by magnetic resonance imaging, (2) the magnetic resonance imaging at disease onset is nondiagnostic for multiple sclerosis (MS), or (3) NMO-IgG seropositivity.2 By convenience, CNS involvement beyond symptoms of optic neuritis and myelitis are compatible with NMO diagnosis. These current diagnostic criteria were 90% specific and 99% sensitive in various populations.