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In reply
In the May 2009 issue of the Archives of Neurology, we published a study describing cross-reactive T cells between tumor and nervous system in a patient with a paraneoplastic syndrome.1 This detailed molecular analysis of lymphocytes' T-cell receptor complementarity-determining region 3 sequence was retrieved from this patient's tumor, peripheral blood, and cerebrospinal fluid, describing ontogenetically distinct, but functionally identical, clones in the different tissues.
The cerebrospinal fluid of this patient was also analyzed for MRZ (measles, rubella, zoster) reaction as 1 of a cohort of 76 patients, without specific reference to individual patients.2 The full neurological and oncological details of this patient can now also be found in another article,3 which describes the antibody status in serum and imaging data (fludeoxyglucose [FDG]–PET). This patient is unusual both oncologically (good tumor prognosis of an adult neuroblastoma) and neurologically (long-term survivor of anti-Hu associated paraneoplastic syndrome).
Both articles1 ,3 present completely separate sets of data from separate biological material (represented by, basically, 2 different groups of investigators), albeit from the same patient. By oversight, we did not cross-reference these 2 complementary articles during an essentially parallel review process. As readers may find added value in considering these 2 studies together, we would have loved to do this, and are very grateful for the opportunity to cross-reference them now.
Correspondence: Dr Voltz, Department of Palliative Medicine, University of Cologne, Kerpener Strasse 62, D-50937 Cologne, Germany (raymond.voltz@uk-koeln.de).
Financial Disclosure: None reported.
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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