Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
We regret the following errors in our ARCHIVES publication.1 Part of our article described the analysis of a polymorphism of the dopamine D4 receptor (DRD4) gene among subjects with Alzheimer disease (AD). We incorrectly referenced the published assay used by one of the coauthors (V.L.N.). The assays actually involved another method.2
Recently, we noted significant differences in the frequency of DRD4 long (DRD4L) alleles among our subjects compared with published figures for normal controls.3 - 5 This prompted us to re-assay DRD4 genotypes among available DNA samples from the original cohort (n = 213) and an additional sample of AD subjects (n = 202), using a minor modification of a published method (details available from R.A.S.).6 These assays were conducted in another coauthor's laboratory (M.I.K.). The DRD4L frequency estimates from the assays using this method were significantly lower than the estimates found using the initial assays. The DRD4 allele frequencies found using the second assays do not differ from published values for normal controls.3 - 5 We consider the second assays more reliable.
The associations of DRD4L examined in our article were retested using the new assay results. Our original manuscript described a weak but statistically significant association between cognitive impairment measured on the Mattis Dementia Rating Scale and the presence of DRD4L. This relationship persisted in the retyped data set but was nonsignificant after controlling for demographic and clinical covariates. None of the other analyses deviated from those in the original report. Further details, including DRD4 allele frequencies, are available from the authors.
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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