0
Article |

Eclamptic Seizures, Magnesium, and Semantics

Raj D Sheth, MD; Jack E. Riggs, MD
Arch Neurol. 1996;53(2):122-122. doi:10.1001/archneur.1996.00550020026009
Text Size: A A A
Published online

Obstetricians have traditionally used magnesium sulfate in the treatment of eclamptic seizures.1 Neurologists, on the other hand, have argued that "magnesium sulfate should not be used as an anticonvulsant therapy for either acute seizure control or seizure prophylaxis" in the patient with eclampsia.2 Indeed, some have gone so far as to suggest that "magnesium sulfate should be relegated to the laboratory, a clinical trial, or history."3 This unyielding stance by neurologists is primarily based on the presumption that magnesium has poor anticonvulsant properties.2 However, two recent studies4,5 conclusively demonstrated the superiority of magnesium over phenytoin or diazepam in preventing seizure recurrence in patients with eclampsia.

Seizures in patients with eclampsia are classified as secondary, as opposed to primary. This distinction is important since treatment of the condition underlying secondary seizures will have an "anticonvulsant" effect. For example, correction of hyponatremia lessens seizure recurrence in severe

REFERENCES

Dinsdale HB.  Does magnesium sulfate treat eclamptic seizures? yes . Arch Neurol . 1988;;45:1360-1361.
Kaplan PW, Lesser RP, Fisher R, Repke JT, Hanley DF.  No, magnesium sulfate should not be used in treating eclamptic seizures . Arch Neurol . 1988;;45:1361-1364.
Hachinski V.  Magnesium sulfate in the treatment of eclampsia . Arch Neurol . 1988;;45:1364.
The Eclampsia Trial Collaborative Group.  Which anticonvulsant for women with eclampsia? evidence from the Collaborative Eclampsia Trial . Lancet . 1995;; 345:1455-1463.
Lucas MJ, Leveno KJ, Cunningham FG.  A comparison of magnesium sulfate and phenytoin for the prevention of eclampsia . N Engl J Med . 1995;;333:201-205.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Dinsdale HB.  Does magnesium sulfate treat eclamptic seizures? yes . Arch Neurol . 1988;;45:1360-1361.
Kaplan PW, Lesser RP, Fisher R, Repke JT, Hanley DF.  No, magnesium sulfate should not be used in treating eclamptic seizures . Arch Neurol . 1988;;45:1361-1364.
Hachinski V.  Magnesium sulfate in the treatment of eclampsia . Arch Neurol . 1988;;45:1364.
The Eclampsia Trial Collaborative Group.  Which anticonvulsant for women with eclampsia? evidence from the Collaborative Eclampsia Trial . Lancet . 1995;; 345:1455-1463.
Lucas MJ, Leveno KJ, Cunningham FG.  A comparison of magnesium sulfate and phenytoin for the prevention of eclampsia . N Engl J Med . 1995;;333:201-205.

Correspondence

CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.