0
January 1995, Vol 52, No. 1 >
Article | January 1995

Medical Treatment of Cysticercosis—Effective

Oscar H. Del Brutto, MD
Arch Neurol. 1995;52(1):102-104. doi:10.1001/archneur.1995.00540250110021
Text Size: A A A
Published online
Article
References
Comments

The first studies on specific drug therapy for neurocysticercosis (NCC) appeared more than one decade ago.1-5 As usually occurs with pioneer work with many other drugs, such studies only included anecdotal case reports or small series of patients with different forms of the disease. Therefore, the efficacy of anticysticercal drugs was difficult to evaluate. A new age of knowledge on medical treatment for NCC began when Sotelo and coworkers6,7 published the first controlled trials of praziquantel therapy in patients with parenchymal brain cysts. The authors used historical controls to demonstrate that viable cysticerci may live unchanged for several years within the brain parenchyma and that a course with praziquantel at daily doses of 50 mg per kilogram of body weight for 15 days destroys more than 60% of these cysts in less than 3 months. Using a similar design, several articles from different areas of the world further

REFERENCES

1 +
Robles C, Chavarría M.  Presentación de un caso clínico de cisticercosis cerebral curado médicamente con un nuevo fármaco: praziquantel . Salud Pub Mex . 1979;;21:603-618.
2 +
Gomez JG, Peña G, Patiño R, Pradilla G.  Neurocysticercosis treated with praziquantel . Neurol Colombia . 1981;;5:665-670.
3 +
Botero D, Castaño S.  Treatment of cysticercosis with praziquantel in Colombia . Am J Trop Med Hyg . 1982;;31:811-821.
4 +
Spina-Franca A, Nobrega JPS, Livramento JA, Machado LR.  Administration of praziquantel in neurocysticercosis . Tropenmed Parasitol . 1982;; 33:1-4.
5 +
Lombardo L, Vasconcelos D, Cruz-Segura H.  Tratamiento de la cisticercosis con praziquantel: informe preliminar de diez casos . Gac Med Mex . 1983;;119:17-22.
6 +
Sotelo J, Escobedo F, Rodriguez-Carbajal J, Torres B, Rubio-Donnadieu F.  Therapy of parenchymal brain cysticercosis with praziquantel . N Engl J Med . 1984;;301:1001-1007.
7 +
Sotelo J, Torres B, Rubio-Donnadieu F, Escobedo F, Rodriguez-Carbajal J.  Praziquantel in the treatment of neurocysticercosis: long-term follow-up . Neurology . 1985;;35:752-754.
8 +
Gómez J, Bustamante-Zuleta E, Sánchez E.  Tratamiento de la cisticercosis con praziquantel: presentación de 50 casos . Neurol Colombia . 1985;; 9:29-35.
9 +
Robles C, Sedano AM, Vargas-Tentori N,  Galindo-Virgen S. Long-term results of praziquantel therapy in neurocysticercosis . J Neurosurg . 1987;;66: 359-363.
10 +
Vasconcelos D, Cruz-Segura H,  Mateos-Gómez H, Zenteno-Alanís G. Selective indications for the use of praziquantel in the treatment of brain cysticercosis . J Neurol Neurosurg Psychiatry . 1987;; 50:383-388.
11 +
vanDellen JR, McKeown CP.  Praziquantel (pirazynoisoquinolone) in active cerebral cysticercosis . Neurosurgery . 1988;;22:92-96.
12 +
Escobedo F, Penagos P, Rodriguez J, Sotelo J.  Albendazole therapy for neurocysticercosis . Arch Intern Med . 1987;;147:738-741.
13 +
Sotelo J, Penagos P, Escobedo F, Del Brutto OH.  Short course of albendazole therapy for neurocysticercosis . Arch Neurol . 1988;;45:1130-1133.
14 +
Escobedo F, Sotelo J, Penagos P, Rodriguez J, Del Brutto OH.  Albendazole therapy for human neurocysticercosis: a controlled trial with computerized tomography and magnetic resonance imaging . Acta Leidensia . 1989;;57:247-254.
15 +
Carpio A, Santillán F, León P, Borrero A, Tinoco L.  New treatment of brain cysticercosis with albendazole . Ann Neurol . 1988;;24:144. Abstract.
16 +
Sotelo J, Escobedo F, Penagos P.  Albendazole VB praziquantel for therapy of neurocysticercosis: a controlled trial . Arch Neurol . 1988;;45:532-534.
17 +
Sotelo J, Del Brutto OH, Penagos P, et al.  Comparison of therapeutic regimen of anticysticercal drugs for parenchymal brain cysticercosis . J Neurol . 1990;;237:69-72.
18 +
Cruz M, Cruz I, Horton J.  Albendazole vs praziquantel in the treatment of cerebral cysticercosis: clinical evaluation . Trans R Soc Trop Med Hyg . 1991;;85:244-247.
19 +
Takayanagui OM, Jardim E.  Therapy for neurocysticercosis: comparison between albendazole and praziquantel . Arch Neurol . 1992;;49:290-294.
20 +
Jung H, Hurtado M, Sánchez M, Medina MT,  Sotelo J. Plasma and CSF levels of albendazole and praziquantel in patients with neurocysticercosis . Clin Neuropharmacol . 1990;:13:559-564.
21 +
Del Brutto OH, Sotelo J.  Albendazole therapy for subarachnoid and ventricular cysticercosis . J Neurosurg . 1990;;72:816-817.
22 +
Santoyo H, Corona R, Sotelo J.  Total recovery of visual function after treatment for cerebral cysticercosis . N Engl J Med . 1991;;324:1137-1139.
23 +
Del Brutto OH, Sotelo J, Aguirre R, Díaz-Calderón E, Alarcón TA.  Albendazole therapy for giant subarachnoid cysticerci . Arch Neurol . 1992;; 49:535-538.
24 +
Del Brutto OH, Sotelo J, Roman GC. Therapy for neurocysticercosis: a reappraisal. Clin Infect Dis. In press.
25 +
Mitchell WG, Crawford TO.  Intraparenchymal cerebral cysticercosis in children: diagnosis and treatment . Pediatrics . 1988;;82:76-82.
26 +
Alcalá H, Sánchez E, Malagón J, Dávila G.  Neurocysticercosis in Mexican children: report of 29 cases . Ann Neurol . 1988;;2:341. Abstract.
27 +
Kramer LD, Locke GE, Byrd SE, Daryabagi J.  Cerebral cysticercosis: documentation of natural history with CT . Radiology . 1989;;170:459-462.
28 +
Medina MT, Cordova S, Genton P, Sotelo J, Dravet C, Montoya MC.  Prognosis of epilepsy in neurocysticercosis: the effect of anticysticercal drug therapy . Epilepsia . 1991;;32( (suppl 1) ):110-111. Abstract.
29 +
Del Brutto OH, Santibañez R, Noboa CA,  Aguirre R, Díaz E, Alarcón TA. Epilepsy due to neurocysticercosis: analysis of 203 patients . Neurology . 1992;; 42:389-392.
30 +
Vazquez N, Sotelo J.  The course of seizures after treatment for cerebral cysticercosis . N Engl J Med . 1992;;327:696-701.
31 +
Kramer LD.  Antihelminthic therapy for neurocysticercosis . Arch Neurol . 1990;;47:1059.
32 +
Chandy MJ, Rajshekhar V, Ghosh S, et al.  Single small enhancing CT lesions in Indian patients with epilepsy: clinical, radiological and pathological considerations . J Neurol Neurosurg Psychiatry . 1991;;54:702-705.
33 +
Ralshekhar V.  Etiology and management of single small CT lesions in patients with seizures: understanding a controversy . Acta Neurol Scand . 1991;;84:465-470.
34 +
Del Brutto OH.  The use of albendazole in patients with single lesions enhanced on contrast CT . N Engl J Med . 1993;;328:356-357.
35 +
Rangel R, Torres B, Del Brutto O, Sotelo J.  Cysticercotic encephalitis: a severe form in young females . Am J Trop Med Hyg . 1987;;36:387-392.
36 +
Sotelo J, Del Brutto OH.  Therapy for neurocysticercosis . Childs Nerv Syst . 1987;;3:208-211.
37 +
Del Brutto OH.  Diagnosis and management of cysticercosis . J Trop Geogr Neurol . 1992;;2:1-9.
38 +
Sotelo J, Guerrero V, Rubio F.  Neurocysticercosis: a new classification based on active and inactive forms . Arch Intern Med . 1985;;145:442-445.
39 +
Del Brutto OH, Sotelo J.  Neurocysticercosis: an update . Rev Infect Dis . 1988;;10:1075-1087.
40 +
deGhetaldi LD, Norman RM, Douville AW Jr.  Cerebral cysticercosis treated biphasically with dexamethasone and praziquantel . Ann Intern Med . 1983;;99:179-181.
41 +
Ciferri F.  Delayed CSF reaction to praziquantel . Lancet . 1988;;1:642-643.
42 +
Del Brutto OH.  Delayed CSF reaction to praziquantel . Lancet . 1988;;2:341.
43 +
Del Brutto OH.  Cysticercosis and cerebrovascular disease: a review . J Neurol Neurosurg Psychiatry . 1992;;55:252-254.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Robles C, Chavarría M.  Presentación de un caso clínico de cisticercosis cerebral curado médicamente con un nuevo fármaco: praziquantel . Salud Pub Mex . 1979;;21:603-618.
2 +
Gomez JG, Peña G, Patiño R, Pradilla G.  Neurocysticercosis treated with praziquantel . Neurol Colombia . 1981;;5:665-670.
3 +
Botero D, Castaño S.  Treatment of cysticercosis with praziquantel in Colombia . Am J Trop Med Hyg . 1982;;31:811-821.
4 +
Spina-Franca A, Nobrega JPS, Livramento JA, Machado LR.  Administration of praziquantel in neurocysticercosis . Tropenmed Parasitol . 1982;; 33:1-4.
5 +
Lombardo L, Vasconcelos D, Cruz-Segura H.  Tratamiento de la cisticercosis con praziquantel: informe preliminar de diez casos . Gac Med Mex . 1983;;119:17-22.
6 +
Sotelo J, Escobedo F, Rodriguez-Carbajal J, Torres B, Rubio-Donnadieu F.  Therapy of parenchymal brain cysticercosis with praziquantel . N Engl J Med . 1984;;301:1001-1007.
7 +
Sotelo J, Torres B, Rubio-Donnadieu F, Escobedo F, Rodriguez-Carbajal J.  Praziquantel in the treatment of neurocysticercosis: long-term follow-up . Neurology . 1985;;35:752-754.
8 +
Gómez J, Bustamante-Zuleta E, Sánchez E.  Tratamiento de la cisticercosis con praziquantel: presentación de 50 casos . Neurol Colombia . 1985;; 9:29-35.
9 +
Robles C, Sedano AM, Vargas-Tentori N,  Galindo-Virgen S. Long-term results of praziquantel therapy in neurocysticercosis . J Neurosurg . 1987;;66: 359-363.
10 +
Vasconcelos D, Cruz-Segura H,  Mateos-Gómez H, Zenteno-Alanís G. Selective indications for the use of praziquantel in the treatment of brain cysticercosis . J Neurol Neurosurg Psychiatry . 1987;; 50:383-388.
11 +
vanDellen JR, McKeown CP.  Praziquantel (pirazynoisoquinolone) in active cerebral cysticercosis . Neurosurgery . 1988;;22:92-96.
12 +
Escobedo F, Penagos P, Rodriguez J, Sotelo J.  Albendazole therapy for neurocysticercosis . Arch Intern Med . 1987;;147:738-741.
13 +
Sotelo J, Penagos P, Escobedo F, Del Brutto OH.  Short course of albendazole therapy for neurocysticercosis . Arch Neurol . 1988;;45:1130-1133.
14 +
Escobedo F, Sotelo J, Penagos P, Rodriguez J, Del Brutto OH.  Albendazole therapy for human neurocysticercosis: a controlled trial with computerized tomography and magnetic resonance imaging . Acta Leidensia . 1989;;57:247-254.
15 +
Carpio A, Santillán F, León P, Borrero A, Tinoco L.  New treatment of brain cysticercosis with albendazole . Ann Neurol . 1988;;24:144. Abstract.
16 +
Sotelo J, Escobedo F, Penagos P.  Albendazole VB praziquantel for therapy of neurocysticercosis: a controlled trial . Arch Neurol . 1988;;45:532-534.
17 +
Sotelo J, Del Brutto OH, Penagos P, et al.  Comparison of therapeutic regimen of anticysticercal drugs for parenchymal brain cysticercosis . J Neurol . 1990;;237:69-72.
18 +
Cruz M, Cruz I, Horton J.  Albendazole vs praziquantel in the treatment of cerebral cysticercosis: clinical evaluation . Trans R Soc Trop Med Hyg . 1991;;85:244-247.
19 +
Takayanagui OM, Jardim E.  Therapy for neurocysticercosis: comparison between albendazole and praziquantel . Arch Neurol . 1992;;49:290-294.
20 +
Jung H, Hurtado M, Sánchez M, Medina MT,  Sotelo J. Plasma and CSF levels of albendazole and praziquantel in patients with neurocysticercosis . Clin Neuropharmacol . 1990;:13:559-564.
21 +
Del Brutto OH, Sotelo J.  Albendazole therapy for subarachnoid and ventricular cysticercosis . J Neurosurg . 1990;;72:816-817.
22 +
Santoyo H, Corona R, Sotelo J.  Total recovery of visual function after treatment for cerebral cysticercosis . N Engl J Med . 1991;;324:1137-1139.
23 +
Del Brutto OH, Sotelo J, Aguirre R, Díaz-Calderón E, Alarcón TA.  Albendazole therapy for giant subarachnoid cysticerci . Arch Neurol . 1992;; 49:535-538.
24 +
Del Brutto OH, Sotelo J, Roman GC. Therapy for neurocysticercosis: a reappraisal. Clin Infect Dis. In press.
25 +
Mitchell WG, Crawford TO.  Intraparenchymal cerebral cysticercosis in children: diagnosis and treatment . Pediatrics . 1988;;82:76-82.
26 +
Alcalá H, Sánchez E, Malagón J, Dávila G.  Neurocysticercosis in Mexican children: report of 29 cases . Ann Neurol . 1988;;2:341. Abstract.
27 +
Kramer LD, Locke GE, Byrd SE, Daryabagi J.  Cerebral cysticercosis: documentation of natural history with CT . Radiology . 1989;;170:459-462.
28 +
Medina MT, Cordova S, Genton P, Sotelo J, Dravet C, Montoya MC.  Prognosis of epilepsy in neurocysticercosis: the effect of anticysticercal drug therapy . Epilepsia . 1991;;32( (suppl 1) ):110-111. Abstract.
29 +
Del Brutto OH, Santibañez R, Noboa CA,  Aguirre R, Díaz E, Alarcón TA. Epilepsy due to neurocysticercosis: analysis of 203 patients . Neurology . 1992;; 42:389-392.
30 +
Vazquez N, Sotelo J.  The course of seizures after treatment for cerebral cysticercosis . N Engl J Med . 1992;;327:696-701.
31 +
Kramer LD.  Antihelminthic therapy for neurocysticercosis . Arch Neurol . 1990;;47:1059.
32 +
Chandy MJ, Rajshekhar V, Ghosh S, et al.  Single small enhancing CT lesions in Indian patients with epilepsy: clinical, radiological and pathological considerations . J Neurol Neurosurg Psychiatry . 1991;;54:702-705.
33 +
Ralshekhar V.  Etiology and management of single small CT lesions in patients with seizures: understanding a controversy . Acta Neurol Scand . 1991;;84:465-470.
34 +
Del Brutto OH.  The use of albendazole in patients with single lesions enhanced on contrast CT . N Engl J Med . 1993;;328:356-357.
35 +
Rangel R, Torres B, Del Brutto O, Sotelo J.  Cysticercotic encephalitis: a severe form in young females . Am J Trop Med Hyg . 1987;;36:387-392.
36 +
Sotelo J, Del Brutto OH.  Therapy for neurocysticercosis . Childs Nerv Syst . 1987;;3:208-211.
37 +
Del Brutto OH.  Diagnosis and management of cysticercosis . J Trop Geogr Neurol . 1992;;2:1-9.
38 +
Sotelo J, Guerrero V, Rubio F.  Neurocysticercosis: a new classification based on active and inactive forms . Arch Intern Med . 1985;;145:442-445.
39 +
Del Brutto OH, Sotelo J.  Neurocysticercosis: an update . Rev Infect Dis . 1988;;10:1075-1087.
40 +
deGhetaldi LD, Norman RM, Douville AW Jr.  Cerebral cysticercosis treated biphasically with dexamethasone and praziquantel . Ann Intern Med . 1983;;99:179-181.
41 +
Ciferri F.  Delayed CSF reaction to praziquantel . Lancet . 1988;;1:642-643.
42 +
Del Brutto OH.  Delayed CSF reaction to praziquantel . Lancet . 1988;;2:341.
43 +
Del Brutto OH.  Cysticercosis and cerebrovascular disease: a review . J Neurol Neurosurg Psychiatry . 1992;;55:252-254.

Correspondence

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems