To the Editor. —Rozental et al1 reported the effect of chemotherapy on the uptake of fluorodeoxyglucose F18 into human gliomas determined by positron emission scanning. They confirmed previous reports that glucose uptake correlates with the histological degree of malignancy and, as had others, attributed the increased uptake to an intrinsically high aerobic glycolytic rate in tumors. Although it is true that most neoplastic cells have a higher rate of aerobic glycolysis (metabolism when fully oxygenated) than their nonneoplastic cells of origin2; it is doubtful that the metabolism of malignant gliomas is truly aerobic. Several years ago we noted that the metabolic enzyme profiles of several experimental neoplasms did suggest a high glycolytic capacity,3 but that changes in glucose, lactate, and high-energy phosphates during ischemia in an experimental ependymoblastoma implanted in mouse brain indicated that the tumors functioned at less than adequate oxygen levels.4,5 Indeed, the high
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
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