0
Article |

A Community-Based Study of Parental Age in Alzheimer-Type Dementia in Western Japan

Katsuya Urakami, MD; Yoshiki Adachi, MD; Kazuro Takahashi, MD
Arch Neurol. 1988;45(4):375-375. doi:10.1001/archneur.1988.00520280017009
Text Size: A A A
Published online

To the Editor.  —A number of studies have identified structural and biochemical similarities between dementia of the Alzheimer type (DAT) and Down's syndrome. Heston1 has reported interesting data that support a common genetic origin for DAT and Down's syndrome. Cohen et al2 first described the fact that offspring born to comparatively old mothers may be at high risk for developing DAT. However, the association between DATAge of Parents at Time of Subject's Birth for Patients With DAT and MID* Mother's Father's Group No. Age, y† Age, y† DAT 77 26.58 ± 6.63‡ 31.44 ± 8.65§ MID 52 24.12 ± 5.73 27.21 ± 6.99 *DAT indicates dementia of the Alzheimer type; MID, multi-infarct dementia. †Values are means ± SDs. ‡P <.05 vs MID group. §P<.01 vs MID group. and maternal age is not yet clarified, and is still controversial.3-7 No information on association between DAT and parental

REFERENCES

Heston LL:  Alzheimer's disease, trisomy 21, and myeloproliferative disorders: Associations suggesting a genetic diathesis . Science 1977;;196:322-323.
Cohen D, Eisdorfer C, Leverenz J:  Alzheimer's disease and maternal age . J Am Geriatr Soc 1982;;30:656-659.
Whalley LJ, Carothers AD, Collyer S, et al:  A study of familial factors in Alzheimer's disease . Br J Psychiatry 1982;;140:249-256.
Corkin S, Growdon JH, Rasmussen L:  Parental age as a risk factor in Alzheimer's disease . Ann Neurol 1983;;13:674-676.
English D, Cohen D:  A case-control study of maternal age in Alzheimer's disease . J Am Geriatr Soc 1985;;33:167-169.
Amaducci L, Fratiglioni L, Rocca WA, et al:  Risk factors for clinically diagnosed Alzheimer's disease: A case-control study of an Italian population . Neurology 1986;;36:922-931.
American Psychiatric Association:  Quick reference to the diagnostic criteria , in Diagnostic and Statistical Manual of Mental Disorders , ed 3. Washington, DC, American Psychiatric Association, 1980;.
Hachinski VC, Illiff LD, Zilhaka E, et al:  Cerebral blood flow in dementia . Arch Neurol 1975;;32:632-637.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Heston LL:  Alzheimer's disease, trisomy 21, and myeloproliferative disorders: Associations suggesting a genetic diathesis . Science 1977;;196:322-323.
Cohen D, Eisdorfer C, Leverenz J:  Alzheimer's disease and maternal age . J Am Geriatr Soc 1982;;30:656-659.
Whalley LJ, Carothers AD, Collyer S, et al:  A study of familial factors in Alzheimer's disease . Br J Psychiatry 1982;;140:249-256.
Corkin S, Growdon JH, Rasmussen L:  Parental age as a risk factor in Alzheimer's disease . Ann Neurol 1983;;13:674-676.
English D, Cohen D:  A case-control study of maternal age in Alzheimer's disease . J Am Geriatr Soc 1985;;33:167-169.
Amaducci L, Fratiglioni L, Rocca WA, et al:  Risk factors for clinically diagnosed Alzheimer's disease: A case-control study of an Italian population . Neurology 1986;;36:922-931.
American Psychiatric Association:  Quick reference to the diagnostic criteria , in Diagnostic and Statistical Manual of Mental Disorders , ed 3. Washington, DC, American Psychiatric Association, 1980;.
Hachinski VC, Illiff LD, Zilhaka E, et al:  Cerebral blood flow in dementia . Arch Neurol 1975;;32:632-637.

Correspondence

CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.