Accepted for publication Oct 7, 1987.
Reprints not available.
The use of levodopa for the treatment of Parkinson's disease has had a remarkable impact on the prognosis of the disorder. Survival now approaches normal age-adjusted life expectancy and levodopa has clearly resulted in lessened morbidity as well, and, thus, an improved quality of life. The limitations of levodopa treatment, however, have become clear. Neurologic disability reappears and worsens over time despite levodopa therapy, the beneficial response to levodopa being lost steadily over several years. Levodopa is symptomatic therapy only, having no influence on the progressive loss of nigral neurons. In addition, levodopa therapy, even in combination with a peripheral levodopa decarboxylase inhibitor, is accompanied by a variety of acute and chronic side effects. The appearance of involuntary movements and fluctuations in motor performance have become major limiting side effects of chronic levodopa therapy.
Due to the limitations of long-term levodopa therapy, attempts have been made to develop novel
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
Instructions
Comments are moderated and will appear on the site at the discretion of the Archives of Neurology editors. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest* Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Customize your page view by dragging & repositioning the boxes below.
and access these and other features:
Register Now
Enter your username and email address. We'll send you a reminder to the email address on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.