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Use of Enzyme-Linked Immunosorbent Assay in the Diagnosis of Cysticercosis

Gerardo Ramirez, MD; Gustavo Pradilla, MD
Arch Neurol. 1987;44(9):898-898. doi:10.1001/archneur.1987.00520210006006
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To the Editor.  —We have read with interest the article by Rosas et al1 on the use of enzyme-linked immunosorbent assay (ELISA) in the diagnosis of cysticercosis.Due to the growing number of cases of cysticercosis found in Colombia, we have studied the clinical, epidemiologic, and immunologic characteristics of this disease.2 An ELISA has been standardized to detect the presence of IgG antibodies against cysticercal antigens in the serum and cerebrospinal fluid of patients with cysticercosis, obtaining a good sensitivity (89% ) and specificity (93%) in serum compared with normal individuals.2,3It is surprising that Rosas et al had not been able to standardize ELISAs to determine IgG antibodies. Cysticercosis is a chronic disease with incubation periods up to 30 years.4,5 In this situation, IgG determination is superior for diagnosis, such that the measurement of IgG antibodies, which are of greater significance during the acute phase of

REFERENCES

Rosas N, Sotelo J, Nieto D:  ELISA in the diagnosis of neurocysticercosis . Arch Neurol 1986;;43:353-356.
Ramirez G, Pradilla G, Rodriguez M, et al:  Cisticercosis: Estudio de 80 casos . Acta Med Col 1986;;11:62-73.
Gonzàlez CI, Ramirez G, Rodriguez M:  ELISA en el diagnóstico de cisticercosis . Rev Univ Ind Santand Med 1985;;13:7-14.
Loo L, Braude A:  Cerebral cysticercosis in San Diego: A report of 23 cases and a review of the literature . Medicine 1982;;61:341-359.
Pradilla G:  Aspectos clinicos de la cisticercosis humana . Rev Univ Ind Santand Med 1986;;14:35-49.
Bidwell DE, Buck AA, Diesfend HJ, et al:  The enzyme-linked immunosorbent assay (ELISA) . Bull WHO 1976;;54:129-139.

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Rosas N, Sotelo J, Nieto D:  ELISA in the diagnosis of neurocysticercosis . Arch Neurol 1986;;43:353-356.
Ramirez G, Pradilla G, Rodriguez M, et al:  Cisticercosis: Estudio de 80 casos . Acta Med Col 1986;;11:62-73.
Gonzàlez CI, Ramirez G, Rodriguez M:  ELISA en el diagnóstico de cisticercosis . Rev Univ Ind Santand Med 1985;;13:7-14.
Loo L, Braude A:  Cerebral cysticercosis in San Diego: A report of 23 cases and a review of the literature . Medicine 1982;;61:341-359.
Pradilla G:  Aspectos clinicos de la cisticercosis humana . Rev Univ Ind Santand Med 1986;;14:35-49.
Bidwell DE, Buck AA, Diesfend HJ, et al:  The enzyme-linked immunosorbent assay (ELISA) . Bull WHO 1976;;54:129-139.

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