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January 1987, Vol 44, No. 1 >
Article | January 1987

Late-Convalescent Poliomyelitis: Title and subTitle BreakCorticospinal Tract Integrity

Paul S. Fishman, MD, PhD
[+] Author Affiliations

Accepted for publication July 24, 1986.

Reprint requests to Department of Neurology and Veterans Administration Research Laboratories, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201 (Dr Fishman).


Arch Neurol. 1987;44(1):98-100. doi:10.1001/archneur.1987.00520130076021
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• Since both poliomyelitis and amyotrophic lateral sclerosis affect spinal motor neurons, a relationship between these two diseases has been suggested. Corticospinal tract (CST) degeneration, a prominent aspect of amyotrophic lateral sclerosis, is rarely observed in acute poliomyelitis. Autopsy material from seven patients who had survived long periods after severe paralytic poliomyelitis was examined for evidence of CST degeneration. Although there was severe motor neuron loss and destruction of ventral horn cytoarchitecture, none of the spinal cords showed significant demyelination, fiber loss, or gliosis in the region of the CST. The structural integrity of the CST is maintained for many years after severe motor neuron loss due to poliomyelitis.

REFERENCES

1 +
Campbell AMG, Williams ER, Pearce J:  Late motor neuron degeneration following poliomyelitis . Neurology 1969;;19:1101-1106.
2 +
Mulder DW, Rosenbaum RA, Layton DD Jr:  Late progression of poliomyelitis or forme fruste of ALS . Mayo Clin Proc 1972;;47:756-761.
3 +
Roos RP, Viola MV, Wollman R, et al:  Amyotrophic lateral sclerosis with antecedent poliomyelitis . Arch Neurol 1980;;37:312-313.
4 +
Viola MV, Lazarus M, Antel J, et al:  Nucleic acid probes in the study of amyotrophic lateral sclerosis , in Rowland LP (ed): Human Motor Neuron Diseases . New York, Raven Press, 1982;, pp 159-164.
5 +
Bell ET:  The progressive pathology of poliomyelitis , in First International Poliomyelitis Congress . New York, JB Lippincott, 1949;, pp 135-141.
6 +
Bodian D:  Histopathological basis of clinical findings in poliomyelitis . Am J Med 1949;;6:563-578.
7 +
Horstmann DM:  Clinical aspects of acute poliomyelitis . Am J Med 1949;;6:592-605.
8 +
Baker AB, Cornell S:  Poliomyelitis: XV. The spinal cord . Arch Pathol Lab Med 1956;;61:185-206.
9 +
Bertrand I, van Bogaert L:  Rapport sur à sclerose laterale amyotrophique . Rev Neurol 1925;;1:779-806.
10 +
Davidson C:  Amyotrophic lateral sclerosis: Origin and extent of the upper motor neuron lesion . Arch Neurol Psychiatry 1941;;46:1039-1056.
11 +
Lawyer T, Netsky MG:  Amyotrophic lateral sclerosis: A clinico-anatomic study of 53 cases . Arch Neurol Psychiatry 1953;;60:171-192.
12 +
Smith MC:  Nerve fiber degeneration in the brain in amyotrophic lateral sclerosis . J Neurol Neurosurg Psychiatry 1960;;23:269-282.
13 +
Brownell B, Oppenheimer DR, Hughes JT:  The central nervous system in motor neuron disease . J Neurol Neurosurg Psychiatry 1970;;33:338-357.
14 +
Hughes JT:  Pathology of amyotrophic lateral sclerosis , in Rowland LP (ed): Human Motor Neuron Diseases . New York, Raven Press, 1982;, pp 61-73.
15 +
Peers JH:  Pathology of convalescent poliomyelitis in man . Am J Pathol 1950;;19:673-695.
16 +
Iwata M, Hirano A:  'Glial bundles' in the spinal cord late after paralytic anterior poliomyelitis . Ann Neurol 1978;;4:562-563.
17 +
Luna LG (ed): Manual of Histologic Staining of the Armed Forces Institute of Pathology . New York, McGraw-Hill International Book Co, 1968;, pp 189-216.
18 +
Miller JR:  Prolonged intracerebral infection with poliovirus in asymptomatic mice . Ann Neurol 1981;;9:590-596.
19 +
Jubelt B, Meagher JB:  Poliovirus infection of cyclophosphamide-treated mice results in persistent and late paralysis . Neurology 1984;;34:486-499.
20 +
Brahic ME, Smith RA, Gibbs CJ, et al:  Detection of picornavirus sequences in CNS tissues of amyotrophic lateral sclerosis and control patients . Ann Neurol 1985;;18:337-343.
21 +
Dalakas M, Elder G, Sever J:  A nine-year follow-up study of patients with late postpoliomyelitis muscular atrophy (PPMA) . Neurology 1985;;35( (suppl 1) ):108.
22 +
Bodian P, Howe HA:  An experimental study of the role of neurons in the dissemination of poliomyelitis virus in the nervous system . Brain 1941;;63:135-161.
23 +
Jubelt B, Gallez-Hawkins G, Narayan O, et al:  Pathogenesis of human poliovirus infection in mice: I. Clinical and pathological studies . J Neuropathol Exp Neurol 1980;;39:149-159.
24 +
Appel SH:  A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer's disease . Ann Neurol 1981;;10:499-505.
25 +
Hollyday M, Hamburger V:  Reduction of naturally occurring motor neuron loss by enlargement of the periphery . J Comp Neurol 1976;;170:311-320.
26 +
Pittman RW, Oppenheim RW:  Neuromuscular blockage increases motor neuron survival during normal cell death in the chick embryo . Nature 1978;;271:364-366.
27 +
Slack JR, Hopkins WG, Pockett S:  Evidence for a motor nerve growth factor . Muscle Nerve 1983;;6:243-252.

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1 +
Campbell AMG, Williams ER, Pearce J:  Late motor neuron degeneration following poliomyelitis . Neurology 1969;;19:1101-1106.
2 +
Mulder DW, Rosenbaum RA, Layton DD Jr:  Late progression of poliomyelitis or forme fruste of ALS . Mayo Clin Proc 1972;;47:756-761.
3 +
Roos RP, Viola MV, Wollman R, et al:  Amyotrophic lateral sclerosis with antecedent poliomyelitis . Arch Neurol 1980;;37:312-313.
4 +
Viola MV, Lazarus M, Antel J, et al:  Nucleic acid probes in the study of amyotrophic lateral sclerosis , in Rowland LP (ed): Human Motor Neuron Diseases . New York, Raven Press, 1982;, pp 159-164.
5 +
Bell ET:  The progressive pathology of poliomyelitis , in First International Poliomyelitis Congress . New York, JB Lippincott, 1949;, pp 135-141.
6 +
Bodian D:  Histopathological basis of clinical findings in poliomyelitis . Am J Med 1949;;6:563-578.
7 +
Horstmann DM:  Clinical aspects of acute poliomyelitis . Am J Med 1949;;6:592-605.
8 +
Baker AB, Cornell S:  Poliomyelitis: XV. The spinal cord . Arch Pathol Lab Med 1956;;61:185-206.
9 +
Bertrand I, van Bogaert L:  Rapport sur à sclerose laterale amyotrophique . Rev Neurol 1925;;1:779-806.
10 +
Davidson C:  Amyotrophic lateral sclerosis: Origin and extent of the upper motor neuron lesion . Arch Neurol Psychiatry 1941;;46:1039-1056.
11 +
Lawyer T, Netsky MG:  Amyotrophic lateral sclerosis: A clinico-anatomic study of 53 cases . Arch Neurol Psychiatry 1953;;60:171-192.
12 +
Smith MC:  Nerve fiber degeneration in the brain in amyotrophic lateral sclerosis . J Neurol Neurosurg Psychiatry 1960;;23:269-282.
13 +
Brownell B, Oppenheimer DR, Hughes JT:  The central nervous system in motor neuron disease . J Neurol Neurosurg Psychiatry 1970;;33:338-357.
14 +
Hughes JT:  Pathology of amyotrophic lateral sclerosis , in Rowland LP (ed): Human Motor Neuron Diseases . New York, Raven Press, 1982;, pp 61-73.
15 +
Peers JH:  Pathology of convalescent poliomyelitis in man . Am J Pathol 1950;;19:673-695.
16 +
Iwata M, Hirano A:  'Glial bundles' in the spinal cord late after paralytic anterior poliomyelitis . Ann Neurol 1978;;4:562-563.
17 +
Luna LG (ed): Manual of Histologic Staining of the Armed Forces Institute of Pathology . New York, McGraw-Hill International Book Co, 1968;, pp 189-216.
18 +
Miller JR:  Prolonged intracerebral infection with poliovirus in asymptomatic mice . Ann Neurol 1981;;9:590-596.
19 +
Jubelt B, Meagher JB:  Poliovirus infection of cyclophosphamide-treated mice results in persistent and late paralysis . Neurology 1984;;34:486-499.
20 +
Brahic ME, Smith RA, Gibbs CJ, et al:  Detection of picornavirus sequences in CNS tissues of amyotrophic lateral sclerosis and control patients . Ann Neurol 1985;;18:337-343.
21 +
Dalakas M, Elder G, Sever J:  A nine-year follow-up study of patients with late postpoliomyelitis muscular atrophy (PPMA) . Neurology 1985;;35( (suppl 1) ):108.
22 +
Bodian P, Howe HA:  An experimental study of the role of neurons in the dissemination of poliomyelitis virus in the nervous system . Brain 1941;;63:135-161.
23 +
Jubelt B, Gallez-Hawkins G, Narayan O, et al:  Pathogenesis of human poliovirus infection in mice: I. Clinical and pathological studies . J Neuropathol Exp Neurol 1980;;39:149-159.
24 +
Appel SH:  A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism, and Alzheimer's disease . Ann Neurol 1981;;10:499-505.
25 +
Hollyday M, Hamburger V:  Reduction of naturally occurring motor neuron loss by enlargement of the periphery . J Comp Neurol 1976;;170:311-320.
26 +
Pittman RW, Oppenheim RW:  Neuromuscular blockage increases motor neuron survival during normal cell death in the chick embryo . Nature 1978;;271:364-366.
27 +
Slack JR, Hopkins WG, Pockett S:  Evidence for a motor nerve growth factor . Muscle Nerve 1983;;6:243-252.

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