0
Article |

Diagnosis of Alzheimer's Disease

Zaven S. Khachaturian, PhD
[+] Author Affiliations

Accepted for publication June 25, 1985.

Reprint requests to National Institute on Aging, 9000 Rockville Pike, Bldg 31, Room 5C27, Bethesda, MD 20205 (Dr Khachaturian).


Arch Neurol. 1985;42(11):1097-1105. doi:10.1001/archneur.1985.04060100083029
Text Size: A A A
Published online

Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. To address the problems involved in diagnosing AD in its earliest stages, the National Institute on Aging, the American Association of Retired Persons, the National Institute of Neurological and Communicative Disorders and Stroke, and the National Institute of Mental Health jointly sponsored a workshop for planning research.

The purpose of the meeting was to identify the most important scientific research opportunities and the crucial clinical and technical issues that influence the progress of research on the diagnosis of AD. The 37 participants included some of the most knowledgeable and eminent scientists and physicians actively involved in the study of AD. The participants were divided among six panels representing the disciplines of neurochemistry, neuropathology, neuroradiology, neurology, neuropsychology, and psychiatry. Within each of the panels, participants discussed specific areas of research requiring further

REFERENCES

National Institute on Aging Task Force Report:  Senility reconsidered: Treatment possibilities for mental impairment in the elderly . JAMA 1980;;244:259-263.
Yahr MD, Wolf A, Antunes JL, et al:  Autopsy findings in parkinsonism following treatment with levodopa . Neurology 1972;;22:56-71.
Chase GA, Folstein MF, Breitner JS, et al:  The use of life tables and survival analysis in testing genetic hypotheses with an application to Alzheimer's disease . Am J Epidemiol 1983;; 117:590-597.
Breitner JCS, Folstein MF:  Familial Alzheimer dementia: A prevalent disorder with specific clinical features . Psychol Med 1984;;14:63-80.
Martin WRW, Adam MJ, Ruth TJ, et al:  The study of dopa metabolism in man with positron emission tomography . Neurology 1985;;35:115.
Wooten GF, Ferrari MB:  Compounds for imaging brain dopamine receptors in vivo . Neurology 1985;;35:115.
Growdon JH, Corkin S, Buonano F, et al: Diagnostic methods in Alzheimer's disease: NMR brain imaging and CSF neurotransmitter markers, in Fisher A, Hanin I, Lachman C (eds): Alzheimer's and Parkinson's Disease: Strategies in Research and Development. New York, Plenum Press, in press.
Kay DWK:  The epidemiology and identification of brain deficit in the elderly , in Eisdorfer C, Friedel RO (ed): Cognitive and Emotional Disturbance in the Elderly . Chicago, Year Book Medical Publishers Inc, 1977;, pp 11-26.
Huff FJ, Maire JC, Growdon JH, et al:  CSF cholinesterases in Alzheimer's disease . Neurology 1985;;35:218.
Hanin I, Reynolds C, Kupfur DJ, et al:  Elevated red blood cell plasma choline ratio in dementia of Alzheimer's type: Clinical and polysomnographic correlates . Psychiatry Res 1984;;13:167-173.
Barclay LL, Kheyfets S, Zemcov A: Red cell plasma choline as marker of severity and genetic predisposition of Alzheimer disease. Neurology, in press.
Richardson AP:  Congo red: Absorption, distribution, and sojourn in blood . Am J Med Sci 1939;;198:87-94.
Richardson AP:  Congo red: Hematologic actions . Am J Med Sci 1939;;198:87-94.
Richardson AP, Dillon JR:  Congo red: Toxicity and systemic actions . Am J Med Sci 1939;; 198:73-82.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

National Institute on Aging Task Force Report:  Senility reconsidered: Treatment possibilities for mental impairment in the elderly . JAMA 1980;;244:259-263.
Yahr MD, Wolf A, Antunes JL, et al:  Autopsy findings in parkinsonism following treatment with levodopa . Neurology 1972;;22:56-71.
Chase GA, Folstein MF, Breitner JS, et al:  The use of life tables and survival analysis in testing genetic hypotheses with an application to Alzheimer's disease . Am J Epidemiol 1983;; 117:590-597.
Breitner JCS, Folstein MF:  Familial Alzheimer dementia: A prevalent disorder with specific clinical features . Psychol Med 1984;;14:63-80.
Martin WRW, Adam MJ, Ruth TJ, et al:  The study of dopa metabolism in man with positron emission tomography . Neurology 1985;;35:115.
Wooten GF, Ferrari MB:  Compounds for imaging brain dopamine receptors in vivo . Neurology 1985;;35:115.
Growdon JH, Corkin S, Buonano F, et al: Diagnostic methods in Alzheimer's disease: NMR brain imaging and CSF neurotransmitter markers, in Fisher A, Hanin I, Lachman C (eds): Alzheimer's and Parkinson's Disease: Strategies in Research and Development. New York, Plenum Press, in press.
Kay DWK:  The epidemiology and identification of brain deficit in the elderly , in Eisdorfer C, Friedel RO (ed): Cognitive and Emotional Disturbance in the Elderly . Chicago, Year Book Medical Publishers Inc, 1977;, pp 11-26.
Huff FJ, Maire JC, Growdon JH, et al:  CSF cholinesterases in Alzheimer's disease . Neurology 1985;;35:218.
Hanin I, Reynolds C, Kupfur DJ, et al:  Elevated red blood cell plasma choline ratio in dementia of Alzheimer's type: Clinical and polysomnographic correlates . Psychiatry Res 1984;;13:167-173.
Barclay LL, Kheyfets S, Zemcov A: Red cell plasma choline as marker of severity and genetic predisposition of Alzheimer disease. Neurology, in press.
Richardson AP:  Congo red: Absorption, distribution, and sojourn in blood . Am J Med Sci 1939;;198:87-94.
Richardson AP:  Congo red: Hematologic actions . Am J Med Sci 1939;;198:87-94.
Richardson AP, Dillon JR:  Congo red: Toxicity and systemic actions . Am J Med Sci 1939;; 198:73-82.

Correspondence

CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.