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Demyelinating Polyradiculitis and Multiple Sclerosis

Charles M. Poser, MD
Arch Neurol. 1982;39(1):67-67. doi:10.1001/archneur.1982.00510130069023
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To the Editor.—  The extraordinarily interesting report by Lassmann et al entitled "Inflammatory Demyelinating Polyradiculitis in a Patient with Multiple Sclerosis" (Archives 1981;38:99-102) must be considered as an important contribution in an area of extreme controversy. First of all, it is regrettable that the clinical history provided is not only scanty but fails to describe the results of neurological examinations in favor of laboratory data. The patient's appearance, with acute bilateral swelling of lids and lips accompanied by facial numbness, is indicative of neither multiple sclerosis nor polyradiculitis! The illustrations of the pathological changes in the CNS, in particular those labeled a through d in their Fig 1, are so miniscule that they provide very little information, although they certainly are suggestive of the lesions of multiple sclerosis. The author's conclusion that "in MS [multiple sclerosis], similarly to EAE [experimental allergic encephalomyelitis],... inflammatory demyelination may sometimes take place in the

REFERENCES

Poser CM:  Exacerbations, activity, and progression in multiple sclerosis . Arch Neurol 1980;;37:471-474.
Uchimura I, Shiraki H:  A contribution to the classification and pathogenesis of demyelinating encephalomyelitis with special reference to the central nervous system lesions caused by preventive inoculation against rabies . J Neuropathol Exp Neurol 1957;;16:139-203.
Iizuka R, Jacob H, Solcher H:  Multiple Sklerose-plaques nach Rubeolenerkrankung . J Neurol Sci 1972;;15:327-338.
Carpenter S, Lampert P:  Post-infectious perivenous encephalitis and acute hemorrhagic leukoencephalitis , in Minckler J (ed): Pathology of the Nervous System . New York, McGraw-Hill Book Co, 1972;, vol 3, pp 2260-2269.
Van Bogaert L:  Histopathologische Studie uber die Encephalitis nach Windpocken (encephalitis post-varicellosa) . Z Neurol Psychiatr 1932;;140:201-217.
Forrester C, Lascelles RG:  Association between polyneuritis and multiple sclerosis . J Neurol Neurosurg Psychiatry 1979;;42:864-866.

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Poser CM:  Exacerbations, activity, and progression in multiple sclerosis . Arch Neurol 1980;;37:471-474.
Uchimura I, Shiraki H:  A contribution to the classification and pathogenesis of demyelinating encephalomyelitis with special reference to the central nervous system lesions caused by preventive inoculation against rabies . J Neuropathol Exp Neurol 1957;;16:139-203.
Iizuka R, Jacob H, Solcher H:  Multiple Sklerose-plaques nach Rubeolenerkrankung . J Neurol Sci 1972;;15:327-338.
Carpenter S, Lampert P:  Post-infectious perivenous encephalitis and acute hemorrhagic leukoencephalitis , in Minckler J (ed): Pathology of the Nervous System . New York, McGraw-Hill Book Co, 1972;, vol 3, pp 2260-2269.
Van Bogaert L:  Histopathologische Studie uber die Encephalitis nach Windpocken (encephalitis post-varicellosa) . Z Neurol Psychiatr 1932;;140:201-217.
Forrester C, Lascelles RG:  Association between polyneuritis and multiple sclerosis . J Neurol Neurosurg Psychiatry 1979;;42:864-866.

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