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January 1981, Vol 38, No. 1 >
Article | January 1981

Herpesviruses and Parkinsonism: Title and subTitle BreakHerpes Simplex Virus Types 1 and 2, and Cytomegalovirus Antibodies in Serum and CSF

Reijo J. Marttila, MD; Urpo K. Rinne, MD; Pekka Halonen, MD; David L. Madden, DVM, PhD; John L. Sever, MD, PhD
[+] Author Affiliations

Accepted for publication April 13, 1980.

Reprint requests to Department of Neurology, University of Turku, SF-20520 Turku 52, Finland (Dr Marttila).


Arch Neurol. 1981;38(1):19-21. doi:10.1001/archneur.1981.00510010045007
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• Antibodies against herpes simplex virus (HSV) types 1 and 2 and cytomegalovirus (CMV) were assayed with a microindirect hemagglutination (IHA) test in the serum of 67 pairs of patients with Parkinson's disease and controls. Cerebrospinal fluid from 30 pairs was assayed. All patient and control serum was tested with a radioimmunoassay (RIA) for antibodies against HSV type 1 subunit antigens. Serum IHA antibody level against HSV type 1 was increased in patients with Parkinson's disease and RIA antibody levels against the same viral antigen were significantly higher in the patients than controls. Herpes simplex virus type 2 and CMV serum antibodies were equal in the patient and control groups. Most of the CSF samples tested negatively for IHA; small and comparable numbers of the patients and controls had low antibody levels against HSV and CMV antigens.

REFERENCES

1 +
Gajdusek DC:  Unconventional viruses and the origin and disappearance of kuru . Science 197:943-960, 1977;.
2 +
Marttila RJ, Arstila P, Nikoskelainen J, et al:  Viral antibodies in the sera from patients with Parkinson disease . Eur Neurol 15:25-33, 1977;.
3 +
Marttila RJ, Rinne UK:  Herpes simplex virus antibodies in patients with Parkinson's disease . J Neurol Sci 35:375-379, 1978;.
4 +
Marttila RJ, Kalimo KOK, Ziola BR, et al:  Herpes simplex virus subunit antibodies in patients with Parkinson's disease . Arch Neurol 35:668-671, 1978;.
5 +
Marttila RJ, Rinne UK:  Epidemiology of Parkinson's disease in Finland . Acta Neurol Scand 54:81-102, 1976;.
6 +
Hoehn MM, Yahr MD:  Parkinsonism: Onset, progression, and mortality . Neurology 17:427-442, 1967;.
7 +
Fuccillo DA, Moder FL, Catalano LW, et al:  Herpesvirus hominis types I and II: A specific microindirect hemagglutination test . Proc Soc Exp Biol Med 133:735-739, 1970;.
8 +
Fuccillo DA, Moder FL, Traub RG, et al:  Microindirect hemagglutination test for cytomegalovirus . Appl Microbiol 21:104-107, 1971;.
9 +
Kalimo KOK, Marttila RJ, Granfors K, et al:  Solid-phase radioimmunoassay of human immunoglobulin M and immunoglobulin G antibodies against herpes simplex virus type 1 capsid, envelope, and excreted antigens . Infect Immun 15:883-889, 1977;.
10 +
Armitage P: Statistical Methods in Medical Research . London, Blackwell Scientific Publications, 1971;, p 126.
11 +
Elizan TS, Madden DL, Noble GR, et al:  Viral antibodies in serum and cerebrospinal fluid of parkinsonian patients and controls . Arch Neurol 36:529-534, 1979;.
12 +
Schwartz J, Elizan TS:  Search for viral particles and virus-specific products in idiopathic Parkinson disease material . Ann Neurol 6:261-263, 1979;.
13 +
Wetmur JG, Schwartz J, Elizan TS:  Nucleic acid homology studies of viral nucleic acids in idiopathic Parkinson's disease . Arch Neurol 36:462-464, 1979;.
14 +
Lehrich JR, Arnason BGW:  Histocompatibility types and viral antibodies . Arch Neurol 33:404-405, 1976;.
15 +
Madden DL, Wallen WC, Sever JL:  Cellular immunology in multiple sclerosis: Response to several viruses , in Karchner D, Lowenthal A, Strosberg AD (eds): Humoral Immunity in Neurological Diseases . New York, Plenum Press Inc, 1979;, pp 17-35.
16 +
Dawidovitz S, Zamir R, Kott E:  HLA antigens in Parkinson's disease , in den Hartog Jager WA, Bruyn GW, Heijstee APJ (eds): 11th World Congress of Neurology . Amsterdam, Excerpta Medica, 1977;, p 126.
17 +
Emile J, Truelle JL, Pouplard A, et al:  Association maladie de Parkinson: Antigénes HLA-B17 et B18 . Nouv Presse Med 6:4144, 1977;.

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1 +
Gajdusek DC:  Unconventional viruses and the origin and disappearance of kuru . Science 197:943-960, 1977;.
2 +
Marttila RJ, Arstila P, Nikoskelainen J, et al:  Viral antibodies in the sera from patients with Parkinson disease . Eur Neurol 15:25-33, 1977;.
3 +
Marttila RJ, Rinne UK:  Herpes simplex virus antibodies in patients with Parkinson's disease . J Neurol Sci 35:375-379, 1978;.
4 +
Marttila RJ, Kalimo KOK, Ziola BR, et al:  Herpes simplex virus subunit antibodies in patients with Parkinson's disease . Arch Neurol 35:668-671, 1978;.
5 +
Marttila RJ, Rinne UK:  Epidemiology of Parkinson's disease in Finland . Acta Neurol Scand 54:81-102, 1976;.
6 +
Hoehn MM, Yahr MD:  Parkinsonism: Onset, progression, and mortality . Neurology 17:427-442, 1967;.
7 +
Fuccillo DA, Moder FL, Catalano LW, et al:  Herpesvirus hominis types I and II: A specific microindirect hemagglutination test . Proc Soc Exp Biol Med 133:735-739, 1970;.
8 +
Fuccillo DA, Moder FL, Traub RG, et al:  Microindirect hemagglutination test for cytomegalovirus . Appl Microbiol 21:104-107, 1971;.
9 +
Kalimo KOK, Marttila RJ, Granfors K, et al:  Solid-phase radioimmunoassay of human immunoglobulin M and immunoglobulin G antibodies against herpes simplex virus type 1 capsid, envelope, and excreted antigens . Infect Immun 15:883-889, 1977;.
10 +
Armitage P: Statistical Methods in Medical Research . London, Blackwell Scientific Publications, 1971;, p 126.
11 +
Elizan TS, Madden DL, Noble GR, et al:  Viral antibodies in serum and cerebrospinal fluid of parkinsonian patients and controls . Arch Neurol 36:529-534, 1979;.
12 +
Schwartz J, Elizan TS:  Search for viral particles and virus-specific products in idiopathic Parkinson disease material . Ann Neurol 6:261-263, 1979;.
13 +
Wetmur JG, Schwartz J, Elizan TS:  Nucleic acid homology studies of viral nucleic acids in idiopathic Parkinson's disease . Arch Neurol 36:462-464, 1979;.
14 +
Lehrich JR, Arnason BGW:  Histocompatibility types and viral antibodies . Arch Neurol 33:404-405, 1976;.
15 +
Madden DL, Wallen WC, Sever JL:  Cellular immunology in multiple sclerosis: Response to several viruses , in Karchner D, Lowenthal A, Strosberg AD (eds): Humoral Immunity in Neurological Diseases . New York, Plenum Press Inc, 1979;, pp 17-35.
16 +
Dawidovitz S, Zamir R, Kott E:  HLA antigens in Parkinson's disease , in den Hartog Jager WA, Bruyn GW, Heijstee APJ (eds): 11th World Congress of Neurology . Amsterdam, Excerpta Medica, 1977;, p 126.
17 +
Emile J, Truelle JL, Pouplard A, et al:  Association maladie de Parkinson: Antigénes HLA-B17 et B18 . Nouv Presse Med 6:4144, 1977;.

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