0
December 1980, Vol 37, No. 12 >
Article | December 1980

Folate and Mineral Metabolism in Poorly Nourished Epileptic Children

Joseph C. Marcus, MB, BCh, FCP(SA); John M. Pettifor, MB, BCh, FCP(SA)
[+] Author Affiliations

Accepted for publication Feb 12, 1980.

Reprints not available.


Arch Neurol. 1980;37(12):772-774. doi:10.1001/archneur.1980.00500610052008
Text Size: A A A
Published online
Article
References
Comments

• Ninety poorly nourished, ambulant, epileptic children, who had been receiving anticonvulsant medications for at least one year, were studied in respect to their folic acid and vitamin D metabolism. Only 11 (12.2%) had borderline or low folate levels. Serum vitamin D levels were low in five (8.9%); serum calcium levels were low in nine (10%); and serum phosphorus levels were low in three (3.3%). Alkaline phosphatase levels were elevated in 19 (21.1%), but whether these arose from bone or liver was not determined. Height retardation did not correlate with abnormal mineral metabolism.

REFERENCES

1 +
Reynolds EH:  Effects of folic acid on mental state and fit frequency of drug-treated epileptics . Lancet 1:1086-1088, 1967;.
2 +
Gordon N:  Folate deficiency from anticonvulsant therapy . Dev Med Child Neurol 10:497-504, 1968;.
3 +
Dent CE, Richens A, Rowe DJF, et al:  Osteomalacia with long-term anticonvulsant therapy in epilepsy . Br Med J 4:69-72, 1970;.
4 +
Richens A, Rowe DJF:  Disturbance of calcium metabolism by anticonvulsant drugs . Br Med J 4:73-76, 1970;.
5 +
Margo G, Baroni Y, Brindley M, et al:  Protein energy malnutrition in coloured children in Western Township, Johannesburg . S Afr Med J 50:1241-1245, 1976;.
6 +
Reynolds EH:  Chronic antiepileptic toxicity: A review . Epilepsia 16:319-352, 1975;.
7 +
Pettifor JM, Ross FP, Wang J:  A competitive protein-binding assay for 25-hydroxyvitamin D . Clin Sci Mol Med 51:605-607, 1976;.
8 +
Apantaku JB, Afonja OA, Boyo AE:  The effect of long-term anticonvulsant therapy on serum calcium, phosphate, and alkaline phosphatase in Nigerian epileptic patients . Trop Geogr Med 27:418-421, 1975;.
9 +
Maxwell JD, Hunter J, Stewart DA, et al:  Folate deficiency after anticonvulsant drugs: An effect of hepatic enzyme induction? Br Med J 1:297-299, 1972;.
10 +
Hunter J, Maxwell JD, Stewart DA, et al:  Altered calcium metabolism in epileptic children on anticonvulsants . Br Med J 4:202-204, 1971;.
11 +
Dahlke MB, Mertens-Roesler E:  Malabsorption of folic acid due to diphenylhydantoin . Blood 30:341-351, 1967;.
12 +
 Anticonvulsant osteomalacia , editorial. Br Med J 2:1340-1341, 1976;.
13 +
Rose M, Johnson I:  Reinterpretation of the haematological effects of anticonvulsant treatment . Lancet 1:1349-1350, 1978;.
14 +
Hahn TJ:  Bone complications of anticonvulsants . Drugs 12:201-211, 1976;.
15 +
Hahn TJ, Hendin BA, Scharp CR, et al:  Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults . N Engl J Med 287:900-903, 1972;.
16 +
Winnacker JL, Yeager H, Saunders JA, et al:  Rickets in children receiving anticonvulsant drugs: Biochemical and hormonal markers . Am J Dis Child 131:286-290, 1977;.
17 +
Reynolds EH:  Neurological aspects of folate and vitamin B12 metabolism . Clin Haematol 5:661-696, 1976;.
18 +
Livingston S, Berman W, Pauli LL:  Anticonvulsant drugs and vitamin D metabolism . JAMA 224:1634-1635, 1972;.
19 +
Christiansen C, Rødbro P:  Anticonvulsant osteomalacia . Br Med J 1:439-440, 1977;.
20 +
 Hazards of overuse of vitamin  D, editorial. Am J Clin Nutr 28:512-513, 1975;.
21 +
Shafer RB, Nuttall FQ:  Calcium and folic acid absorption in patients taking anticonvulsant drugs . J Clin Endocrinol Metab 41:1125-1129, 1975;.
22 +
Christiansen C, Rødbro P, Sjo O:  Biochemical status in epileptic patients during treatment with vitamin D . Acta Neurol Scand 52:81-86, 1975;.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Reynolds EH:  Effects of folic acid on mental state and fit frequency of drug-treated epileptics . Lancet 1:1086-1088, 1967;.
2 +
Gordon N:  Folate deficiency from anticonvulsant therapy . Dev Med Child Neurol 10:497-504, 1968;.
3 +
Dent CE, Richens A, Rowe DJF, et al:  Osteomalacia with long-term anticonvulsant therapy in epilepsy . Br Med J 4:69-72, 1970;.
4 +
Richens A, Rowe DJF:  Disturbance of calcium metabolism by anticonvulsant drugs . Br Med J 4:73-76, 1970;.
5 +
Margo G, Baroni Y, Brindley M, et al:  Protein energy malnutrition in coloured children in Western Township, Johannesburg . S Afr Med J 50:1241-1245, 1976;.
6 +
Reynolds EH:  Chronic antiepileptic toxicity: A review . Epilepsia 16:319-352, 1975;.
7 +
Pettifor JM, Ross FP, Wang J:  A competitive protein-binding assay for 25-hydroxyvitamin D . Clin Sci Mol Med 51:605-607, 1976;.
8 +
Apantaku JB, Afonja OA, Boyo AE:  The effect of long-term anticonvulsant therapy on serum calcium, phosphate, and alkaline phosphatase in Nigerian epileptic patients . Trop Geogr Med 27:418-421, 1975;.
9 +
Maxwell JD, Hunter J, Stewart DA, et al:  Folate deficiency after anticonvulsant drugs: An effect of hepatic enzyme induction? Br Med J 1:297-299, 1972;.
10 +
Hunter J, Maxwell JD, Stewart DA, et al:  Altered calcium metabolism in epileptic children on anticonvulsants . Br Med J 4:202-204, 1971;.
11 +
Dahlke MB, Mertens-Roesler E:  Malabsorption of folic acid due to diphenylhydantoin . Blood 30:341-351, 1967;.
12 +
 Anticonvulsant osteomalacia , editorial. Br Med J 2:1340-1341, 1976;.
13 +
Rose M, Johnson I:  Reinterpretation of the haematological effects of anticonvulsant treatment . Lancet 1:1349-1350, 1978;.
14 +
Hahn TJ:  Bone complications of anticonvulsants . Drugs 12:201-211, 1976;.
15 +
Hahn TJ, Hendin BA, Scharp CR, et al:  Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults . N Engl J Med 287:900-903, 1972;.
16 +
Winnacker JL, Yeager H, Saunders JA, et al:  Rickets in children receiving anticonvulsant drugs: Biochemical and hormonal markers . Am J Dis Child 131:286-290, 1977;.
17 +
Reynolds EH:  Neurological aspects of folate and vitamin B12 metabolism . Clin Haematol 5:661-696, 1976;.
18 +
Livingston S, Berman W, Pauli LL:  Anticonvulsant drugs and vitamin D metabolism . JAMA 224:1634-1635, 1972;.
19 +
Christiansen C, Rødbro P:  Anticonvulsant osteomalacia . Br Med J 1:439-440, 1977;.
20 +
 Hazards of overuse of vitamin  D, editorial. Am J Clin Nutr 28:512-513, 1975;.
21 +
Shafer RB, Nuttall FQ:  Calcium and folic acid absorption in patients taking anticonvulsant drugs . J Clin Endocrinol Metab 41:1125-1129, 1975;.
22 +
Christiansen C, Rødbro P, Sjo O:  Biochemical status in epileptic patients during treatment with vitamin D . Acta Neurol Scand 52:81-86, 1975;.

Correspondence

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems