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January 1979, Vol 36, No. 1 >
Article | January 1979

Postanoxic Action Myoclonus (Lance-Adams Syndrome) Responding to Valproate

Russell D. Rollinson, FRACP; Bernard S. Gilligan, FRACP
[+] Author Affiliations

Accepted for publication Nov 21, 1977.

Reprint requests to Department of Neurology, Vanderbilt Medical Center, Vanderbilt University, Nashville, TN 37232 (Dr Rollinson).


Arch Neurol. 1979;36(1):44-45. doi:10.1001/archneur.1979.00500370074019
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• A patient with postanoxic action myoclonus (Lance-Adams syndrome) was severely disabled with this movement disorder. Valproate sodium was administered orally, with complete resolution of the myoclonus. This favorable response has been maintained for two years. Excessive yawning, the only side effect encountered, was dose related and was abolished with the addition of pimozide to the drug regimen.

REFERENCES

1 +
Lance JW, Adams RD:  The syndrome of intention or action myoclonus as a sequel to hypoxic encephalography . Brain 86:111-134, 1963;.
2 +
Van Woert M, Sethy V:  Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486 . Neurology 25:135-140, 1975;.
3 +
Guilleminault C, Tharp B, Cousin D:  HVA and 5HIAA CSF measurements and 5HTP trials in some patients with involuntary movements . J Neurol Sci 18:435-441, 1973;.
4 +
Richardson JC, Rewcastle B, De Lean J: Hypoxic myoclonus: Clinical and pathological observations, in Proceedings of the Sir Gordon Holmes Centennial Meeting, London, March, 1976. Edinburgh, William Blackwood & Sons Ltd, to be published.
5 +
De Lean J:  Action myoclonus and serotoninergic activity . N Engl J Med 286:1414-1415, 1977;.
6 +
Lhermitte F, Talairach J, Buser P, et al:  Myoclonies d'intention et d'action postanoxiques: Etude stereotaxique et destruction du noyau ventral lateral du thalamus . Rev Neurol 124:1-20, 1971;.
7 +
Lhermitte F, Peterfalvi M, Marteau R, et al:  Analyse pharmacologique d'un cas de myoclonies d'intention et d'action postanoxiques . Rev Neurol 124:21-31, 1971;.
8 +
Lhermitte F, Marteau R, Degos C:  Analyse pharmacologique d'un nouveau cas de myoclonies d'intention d'action post-anoxiques . Rev Neurol 126:107-114, 1972;.
9 +
Chadwick D, Harris R, Jenner P, et al:  Manipulation of brain serotonin in the treatment of myoclonus . Lancet 2:434-435, 1975;.
10 +
Minoli G, Tredici G:  Levodopa in the treatment of myoclonus . Lancet 2:472, 1974;.
11 +
Bedard P, Bouchard R:  Dramatic effect of Methysergide on myoclonus . Lancet 1:738, 1974;.
12 +
Hirose G, Singer P, Bass N:  Successful treatment of post hypoxic action myoclonus with carbamazepine . JAMA 218:1432-1433, 1971;.
13 +
Sherwin I, Redmon W:  Successful treatment in action myoclonus . Neurology 19:846-850, 1969;.
14 +
Thal L, Sharpless N, Wolfson L, et al:  Clinical and metabolic observations on the treatment of myoclonus with L-HTP and carbidopa . Trans Am Neurol Assoc 101:48-52, 1976;.
15 +
Jeavons P, Clark J:  Sodium valproate in the treatment of epilepsy . Br Med J 1:584-586, 1974;.
16 +
Godin Y, Heiner J, Mandel P:  Effects of di-n-propylacetate, an anticonvulsant compound, on GABA metabolism . J Neurochem 16:869-873, 1969;.
17 +
Tomlinson EB:  Progressive myoclonic epilepsy: The response to sodium di-n-propylacetate . Proc Aust Assoc Neurol 11:203-208, 1974;.
18 +
Lyeke E, Roos BE:  Influence in brain monoamine: Metabolism on behavior of herpes simplex infected mice . J Neurol Sci 22:277-289, 1976;.
19 +
McArthur AW, Pollock M, Smidt NA:  Combined therapy with tetrabenazine and pimozide in Huntington's chorea . NZ Med J 83:114-116, 1976;.

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1 +
Lance JW, Adams RD:  The syndrome of intention or action myoclonus as a sequel to hypoxic encephalography . Brain 86:111-134, 1963;.
2 +
Van Woert M, Sethy V:  Therapy of intention myoclonus with L-5-hydroxytryptophan and a peripheral decarboxylase inhibitor, MK 486 . Neurology 25:135-140, 1975;.
3 +
Guilleminault C, Tharp B, Cousin D:  HVA and 5HIAA CSF measurements and 5HTP trials in some patients with involuntary movements . J Neurol Sci 18:435-441, 1973;.
4 +
Richardson JC, Rewcastle B, De Lean J: Hypoxic myoclonus: Clinical and pathological observations, in Proceedings of the Sir Gordon Holmes Centennial Meeting, London, March, 1976. Edinburgh, William Blackwood & Sons Ltd, to be published.
5 +
De Lean J:  Action myoclonus and serotoninergic activity . N Engl J Med 286:1414-1415, 1977;.
6 +
Lhermitte F, Talairach J, Buser P, et al:  Myoclonies d'intention et d'action postanoxiques: Etude stereotaxique et destruction du noyau ventral lateral du thalamus . Rev Neurol 124:1-20, 1971;.
7 +
Lhermitte F, Peterfalvi M, Marteau R, et al:  Analyse pharmacologique d'un cas de myoclonies d'intention et d'action postanoxiques . Rev Neurol 124:21-31, 1971;.
8 +
Lhermitte F, Marteau R, Degos C:  Analyse pharmacologique d'un nouveau cas de myoclonies d'intention d'action post-anoxiques . Rev Neurol 126:107-114, 1972;.
9 +
Chadwick D, Harris R, Jenner P, et al:  Manipulation of brain serotonin in the treatment of myoclonus . Lancet 2:434-435, 1975;.
10 +
Minoli G, Tredici G:  Levodopa in the treatment of myoclonus . Lancet 2:472, 1974;.
11 +
Bedard P, Bouchard R:  Dramatic effect of Methysergide on myoclonus . Lancet 1:738, 1974;.
12 +
Hirose G, Singer P, Bass N:  Successful treatment of post hypoxic action myoclonus with carbamazepine . JAMA 218:1432-1433, 1971;.
13 +
Sherwin I, Redmon W:  Successful treatment in action myoclonus . Neurology 19:846-850, 1969;.
14 +
Thal L, Sharpless N, Wolfson L, et al:  Clinical and metabolic observations on the treatment of myoclonus with L-HTP and carbidopa . Trans Am Neurol Assoc 101:48-52, 1976;.
15 +
Jeavons P, Clark J:  Sodium valproate in the treatment of epilepsy . Br Med J 1:584-586, 1974;.
16 +
Godin Y, Heiner J, Mandel P:  Effects of di-n-propylacetate, an anticonvulsant compound, on GABA metabolism . J Neurochem 16:869-873, 1969;.
17 +
Tomlinson EB:  Progressive myoclonic epilepsy: The response to sodium di-n-propylacetate . Proc Aust Assoc Neurol 11:203-208, 1974;.
18 +
Lyeke E, Roos BE:  Influence in brain monoamine: Metabolism on behavior of herpes simplex infected mice . J Neurol Sci 22:277-289, 1976;.
19 +
McArthur AW, Pollock M, Smidt NA:  Combined therapy with tetrabenazine and pimozide in Huntington's chorea . NZ Med J 83:114-116, 1976;.

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