0
July 1973, Vol 29, No. 1 >
Article | July 1973

Immunologic Mechanisms in Experimental Encephalomyelitis in Nonhuman Primates

Peter O. Behan, MD; Marian W. Kies, PhD; Robert P. Lisak, MD; William Sheremata, MD; Jacques B. Lamarche
[+] Author Affiliations

Accepted for publication Feb 21, 1973.

Read in part before the annual meeting of the American Association of Neuropathologists, New Haven, Conn, June 22, 1969.

Reprint requests to Veterans Administration Hospital, Department of Neurology, 150 S Huntington Ave, Boston 02130 (Dr. Behan).


Arch Neurol. 1973;29(1):4-9. doi:10.1001/archneur.1973.00490250022002
Text Size: A A A
Published online
Article
References
Comments

Experimental allergic encephalomyelitis was induced in large rhesus monkeys by immunizing them with homologous and heterologous myelin basic proteins in different adjuvants. Two clinically and pathologically different types of disease, ordinary and hyperacute, were produced. In both types cell-mediated hypersensitivity was demonstrated to a variety of myelin basic proteins from different species by in vivo and in vitro techniques. Humoral antibody to homologous myelin basic protein could only be found in the fulminant hyperacute form.

REFERENCES

1 +
Rivers TM, Schwentker FF:  Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys . J Exp Med 61:689-702, 1935;.
2 +
Alvord EC Jr:  Acute disseminated encephalomyelitis and "allergic" neuro-encephalopathies , in Vinken PJ, Bruyn GW (eds): Handbook of Clinical Neurology . Amsterdam, North-Holland Publishing Co, 1970;, vol 9, pp 500-571.
3 +
Kies MW, Alvord EC Jr:  Encephalitogenic activity in guinea pigs of water-soluble protein fractions of nervous tissue , in Kies MW, Alvord EC Jr (eds): "Allergic" Encephalomyelitis . Springfield, Ill, Charles C Thomas Publisher, 1959;, pp 281-293.
4 +
Roboz-Einstein E et al:  The isolation from bovine spinal cord of a homogeneous protein with encephalitogenic activity . J Neurochem 9: 353-361, 1962;.
5 +
Paterson PY:  Transfer of allergic encephalomyelitis in rats by means of lymph node cells . J Exp Med 111:119-136, 1960;.
6 +
Stone SH:  Transfer of allergic encephalomyelitis by lymph node cells in inbred guinea pigs . Science 134:619-620, 1961;.
7 +
Chase MW:  A critique of attempts at passive transfer of sensitivity to nervous tissue , in Kies MW, Alvord EC Jr (eds): "Allergic" Encephalomyelitis , Springfield, Ill, Charles C Thomas Publisher, 1959;, pp 348-387.
8 +
Shaw CM et al:  Correlation of experimental allergic encephalomyelitis with delayed-type skin sensitivity to specific homologous encephalitogen . Ann NY Acad Sci 122:318-331, 1965;.
9 +
Lisak RP et al:  Antibodies to encephalitogenic basic protein in experimental allergic encephalomyelitis . Proc Soc Exp Biol Med 130:814-818, 1969;.
10 +
Kies MW:  The biological activity of myelin basic proteins , in Wolfgram F et al (eds): Multiple Sclerosis: Immunology, Virology, and Ultrastructure . New York, Academic Press, 1972;, pp 429-448.
11 +
Martenson RE, et al:  Myelin basic proteins of mammalian and submammalian vertebrates: Encephalitogenic activities in guinea pigs and rats . J Immunol 109:262-270, 1972;.
12 +
Behan PO et al:  Delayed hypersensitivity to encephalitogenic protein in disseminated encephalomyelitis . Lancet 2:1009-1012, 1968;.
13 +
Behan PO et al:  Cell-mediated hypersensitivity to neural antigens: Occurrence in human patients and nonhuman primates with neurological diseases . Arch Neurol 27:145-152, 1972;.
14 +
Deibler GE, Martenson RE, Kies MW:  Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species . Prep Biochem 2:139-165, 1972;.
15 +
Rocklin RE, Meyers OL, David JR:  An in vitro assay for cellular hypersensitivity in man . J Immunol 104:95-102, 1970;.
16 +
Lisak RP, Heinze RG, Kies MW:  Relationships between antibodies and experimental allergic encephalomyelitis: III. Coprecipitation and radioautography of 125I-labeled antigen-antibody complexes for detection of antibodies to myelin basic protein . Int Arch Allergy Appl Immunol 37:621-629, 1970;.
17 +
Bornstein MB, Appel SH:  The application of tissue culture to the study of experimental allergic encephalomyelitis: I. Patterns of demyelination . J Neuropath Exp Neurol 20:141-157, 1961;.
18 +
Bornstein MB, Raine CS:  Experimental allergic encephalomyelitis: Antiserum inhibition of myelination in vitro . Lab Invest 23:536-542, 1970;.
19 +
Seil FJ et al:  The in vitro demyelinating activity of sera from guinea pigs sensitized with whole CNS and with purified encephalitogen . Exp Neurol 22:545-555, 1968;.
20 +
Kies MW et al:  Myelination inhibition factor: Dissociation from induction of experimental allergic encephalomyelitis . Science 179: 689-690, 1972;.
21 +
Falk GA, Kies MW, Alvord EC Jr:  Delayed hypersensitivity to myelin basic protein in the passive transfer of experimental allergic encephalomyelitis . J Immunol 101:638-644, 1968;.
22 +
Dau PC, Petersen RDA:  Transformation of rodent lymphoid cells by an encephalitogen of human origin . Int Arch Allergy Appl Immunol 35:353-368, 1969;.
23 +
Fowler I:  In vitro responses of peripheral blood lymphocytes in experimental allergic encephalomyelitis . J Immunol 108:903-906, 1972;.
24 +
Warnatz H, Scheiffarth F, Kuntz H:  Studies on lymphocyte transformation in experimental allergic encephalomyelitis . J Neuropath Exp Neurol 29:575-582, 1970;.
25 +
Rauch HC et al:  Inhibition of in vitro cell migration in experimental allergic encephalomyelitis . J Immunol 102:1431-1436, 1969;.
26 +
Chaparas SD et al:  Transformation of lymphocytes from monkeys with experimental allergic encephalomyelitis . Res Commun Chem Pathol Pharmacol 1:637-652, 1970;.
27 +
Eylar EH et al:  Allergic encephalomyelitis in monkeys induced by a peptide from the Al protein . Proc Nat Acad Sci 69:617-619, 1972;.
28 +
Behan PO et al: In vitro studies of immunological mechanisms in experimental allergic encephalomyelitis. Read before the 45th Annual Meeting of American Association of Neuropathologists, 1969.
29 +
Dowling P, Cook S:  The in vitro synthesis of a demyelinating factor by circulating immunocytes in EAE . Neurology 18:295-296, 1968;.
30 +
Russell DS:  The nosological unity of acute hemorrhagic leucoencephalitis and acute disseminated encephalomyelitis . Brain 78:369-376, 1955;.
31 +
Levine S, Wenk EJ:  A hyperacute form of allergic encephalomyelitis . Am J Pathol 47:61-88, 1965;.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

1 +
Rivers TM, Schwentker FF:  Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys . J Exp Med 61:689-702, 1935;.
2 +
Alvord EC Jr:  Acute disseminated encephalomyelitis and "allergic" neuro-encephalopathies , in Vinken PJ, Bruyn GW (eds): Handbook of Clinical Neurology . Amsterdam, North-Holland Publishing Co, 1970;, vol 9, pp 500-571.
3 +
Kies MW, Alvord EC Jr:  Encephalitogenic activity in guinea pigs of water-soluble protein fractions of nervous tissue , in Kies MW, Alvord EC Jr (eds): "Allergic" Encephalomyelitis . Springfield, Ill, Charles C Thomas Publisher, 1959;, pp 281-293.
4 +
Roboz-Einstein E et al:  The isolation from bovine spinal cord of a homogeneous protein with encephalitogenic activity . J Neurochem 9: 353-361, 1962;.
5 +
Paterson PY:  Transfer of allergic encephalomyelitis in rats by means of lymph node cells . J Exp Med 111:119-136, 1960;.
6 +
Stone SH:  Transfer of allergic encephalomyelitis by lymph node cells in inbred guinea pigs . Science 134:619-620, 1961;.
7 +
Chase MW:  A critique of attempts at passive transfer of sensitivity to nervous tissue , in Kies MW, Alvord EC Jr (eds): "Allergic" Encephalomyelitis , Springfield, Ill, Charles C Thomas Publisher, 1959;, pp 348-387.
8 +
Shaw CM et al:  Correlation of experimental allergic encephalomyelitis with delayed-type skin sensitivity to specific homologous encephalitogen . Ann NY Acad Sci 122:318-331, 1965;.
9 +
Lisak RP et al:  Antibodies to encephalitogenic basic protein in experimental allergic encephalomyelitis . Proc Soc Exp Biol Med 130:814-818, 1969;.
10 +
Kies MW:  The biological activity of myelin basic proteins , in Wolfgram F et al (eds): Multiple Sclerosis: Immunology, Virology, and Ultrastructure . New York, Academic Press, 1972;, pp 429-448.
11 +
Martenson RE, et al:  Myelin basic proteins of mammalian and submammalian vertebrates: Encephalitogenic activities in guinea pigs and rats . J Immunol 109:262-270, 1972;.
12 +
Behan PO et al:  Delayed hypersensitivity to encephalitogenic protein in disseminated encephalomyelitis . Lancet 2:1009-1012, 1968;.
13 +
Behan PO et al:  Cell-mediated hypersensitivity to neural antigens: Occurrence in human patients and nonhuman primates with neurological diseases . Arch Neurol 27:145-152, 1972;.
14 +
Deibler GE, Martenson RE, Kies MW:  Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species . Prep Biochem 2:139-165, 1972;.
15 +
Rocklin RE, Meyers OL, David JR:  An in vitro assay for cellular hypersensitivity in man . J Immunol 104:95-102, 1970;.
16 +
Lisak RP, Heinze RG, Kies MW:  Relationships between antibodies and experimental allergic encephalomyelitis: III. Coprecipitation and radioautography of 125I-labeled antigen-antibody complexes for detection of antibodies to myelin basic protein . Int Arch Allergy Appl Immunol 37:621-629, 1970;.
17 +
Bornstein MB, Appel SH:  The application of tissue culture to the study of experimental allergic encephalomyelitis: I. Patterns of demyelination . J Neuropath Exp Neurol 20:141-157, 1961;.
18 +
Bornstein MB, Raine CS:  Experimental allergic encephalomyelitis: Antiserum inhibition of myelination in vitro . Lab Invest 23:536-542, 1970;.
19 +
Seil FJ et al:  The in vitro demyelinating activity of sera from guinea pigs sensitized with whole CNS and with purified encephalitogen . Exp Neurol 22:545-555, 1968;.
20 +
Kies MW et al:  Myelination inhibition factor: Dissociation from induction of experimental allergic encephalomyelitis . Science 179: 689-690, 1972;.
21 +
Falk GA, Kies MW, Alvord EC Jr:  Delayed hypersensitivity to myelin basic protein in the passive transfer of experimental allergic encephalomyelitis . J Immunol 101:638-644, 1968;.
22 +
Dau PC, Petersen RDA:  Transformation of rodent lymphoid cells by an encephalitogen of human origin . Int Arch Allergy Appl Immunol 35:353-368, 1969;.
23 +
Fowler I:  In vitro responses of peripheral blood lymphocytes in experimental allergic encephalomyelitis . J Immunol 108:903-906, 1972;.
24 +
Warnatz H, Scheiffarth F, Kuntz H:  Studies on lymphocyte transformation in experimental allergic encephalomyelitis . J Neuropath Exp Neurol 29:575-582, 1970;.
25 +
Rauch HC et al:  Inhibition of in vitro cell migration in experimental allergic encephalomyelitis . J Immunol 102:1431-1436, 1969;.
26 +
Chaparas SD et al:  Transformation of lymphocytes from monkeys with experimental allergic encephalomyelitis . Res Commun Chem Pathol Pharmacol 1:637-652, 1970;.
27 +
Eylar EH et al:  Allergic encephalomyelitis in monkeys induced by a peptide from the Al protein . Proc Nat Acad Sci 69:617-619, 1972;.
28 +
Behan PO et al: In vitro studies of immunological mechanisms in experimental allergic encephalomyelitis. Read before the 45th Annual Meeting of American Association of Neuropathologists, 1969.
29 +
Dowling P, Cook S:  The in vitro synthesis of a demyelinating factor by circulating immunocytes in EAE . Neurology 18:295-296, 1968;.
30 +
Russell DS:  The nosological unity of acute hemorrhagic leucoencephalitis and acute disseminated encephalomyelitis . Brain 78:369-376, 1955;.
31 +
Levine S, Wenk EJ:  A hyperacute form of allergic encephalomyelitis . Am J Pathol 47:61-88, 1965;.

Correspondence

Submit a Letter
CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Compression-Only CPR: Pushing the Science Forward
Cone
AAM 2010;304:1493-1495.
All you need to read in the other general journals
BMJ 2010;341:c5893-c1494.
Submit a Response

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

© 2012 American Medical Association. All Rights Reserved.
Powered bySilverchair Information Systems