0
Article |

Cerebrospinal Fluid Absorption: Title and subTitle BreakIn Animals With Experimental Obstructive Hydrocephalus

Abraham Sahar, MD; Gerald M. Hochwald, MD; Abdul R. Sadik, MD; Joseph Ransohoff, MD
[+] Author Affiliations

Submitted for publication June 25, 1969; accepted Aug 18.

Reprint requests to the Department of Neurology and Psychiatry, New York University Medical Center, 550 First Ave, New York 10016 (Dr. Hochwald).


Arch Neurol. 1969;21(6):638-644. doi:10.1001/archneur.1969.00480180094009
Text Size: A A A
Published online

WHEN NEWLY formed cerebrospinal fluid (CSF) is prevented from reaching the subarachnoid space and its normal extraventricular absorption sites, it is still being removed from the ventricular system. With continuous CSF production, an alternate mechanism for the absorption of CSF must therefore be assumed. Otherwise, accumulation of CSF would lead to rapid death due to marked elevation of intraventricular pressure.

The mechanism by which CSF is capable of being removed from the isolated ventricles in naturally occurring noncommunicating hydrocephalus or under experimental conditions is as yet unknown. Some factors instrumental to the absorption of fluid must include increased intraventricular pressure, a larger ventricular surface area, channels available for flow of fluid from the ventricles to the blood, and a relationship between ventricular pressure and periventricular venous pressure which would favor absorption.

A study of transventricular flow of CSF has been made possible with the development of perfusion methods

REFERENCES

Pappenheimer, J.R.; Heisey, S.R.; and Jordan, E.F.:  Active Transport of Diodrast and Phenolsulfonphthalein From Cerebrospinal Fluid to Blood , Amer J Physiol 200:1-10 ( (Jan) ) 1961;.
Bering, E.A., Jr., and Sato, O.:  Hydrocephalus: Changes in Formation and Absorption of Cerebrospinal Fluid Within the Cerebral Ventricles , J Neurosurg 20:1050-1063 ( (Dec) ) 1963;.
Hochwald, G.M., et al:  Cerebrospinal Fluid Production and Histological Observations in Animals With Experimental Obstructive Hydrocephalus , Exp Neurol , to be published.
Hochwald, G.M., and Wallenstein, M.:  Exchange of Albumin Between Blood, Cerebrospinal Fluid and Brain in the Cat , Amer J Physiol 212:1199-1204 ( (May) ) 1967;.
Schreiner, G.E.:  Determination of Inulin by Means of Resorcinol , Proc Soc Exp Biol Med 74:117-120 ( (May) ) 1950;.
Cutler, R.W.P.; Robinson, R.J.; and Lorenzo, A.V.:  Cerebrospinal Fluid Transport of Sulfate in the Cat , Amer J Physiol 214:448-454 ( (March) ) 1968;.
Heisey, S.R.; Held, D.; and Pappenheimer, J.R.:  Bulk Flow and Diffusion in the Cerebrospinal Fluid System of the Goat , Amer J Physiol 203:775-781 ( (May) ) 1962;.
Pappenheimer, J.R., et al:  Perfusion of the Cerebral Ventricular System in Unanesthetized Goats , Amer J Physiol 203:763-774 ( (May) ) 1962;.
Calhoun, M.C., et al:  Rates of Formation and Absorption of Cerebrospinal Fluid in Holstein Male Calves , Univ Conn Coll Agr Exp Sta Bull 401:22 ( (Feb) ) 1967;.
Cutler, R.W.P., et al:  Formation and Absorption of Cerebrospinal Fluid in Man , Brain 91:707-720 ( (Dec) ) 1968;.
Hochwald, G.M., and Wallenstein, M.C.:  Exchange of υ-Globulin Between Blood, Cerebrospinal Fluid and Brain in the Cat , Exp Neurol 19:115-126 ( (Sept) ) 1967;.
Cutler, R.W.P., and Lorenzo, A.V.:  Transport of L-Aminocyclopentanecarboxylic Acid From Feline Cerebrospinal Fluid , Science 161:1363 ( (Sept) ) 1968;.
Davson, H., and Spaziani, E.:  The Blood-Brain Barrier , J Physiol 149:135-143 ( (Dec) ) 1959;.
Rosomoff, H.L.:  Method for Simultaneous Quantitative Estimation of Intracranial Contents , J Appl Physiol 16:395-396 ( (March) ) 1961;.
Geschwind, N.:  The Mechanism of Normal Pressure Hydrocephalus , J Neurol Sci 7:481-493 ( (Nov-Dec) ) 1968;.

First Page Preview

First page PDF preview

Figures

Tables

Interactive Graphics

Video

Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal

Pappenheimer, J.R.; Heisey, S.R.; and Jordan, E.F.:  Active Transport of Diodrast and Phenolsulfonphthalein From Cerebrospinal Fluid to Blood , Amer J Physiol 200:1-10 ( (Jan) ) 1961;.
Bering, E.A., Jr., and Sato, O.:  Hydrocephalus: Changes in Formation and Absorption of Cerebrospinal Fluid Within the Cerebral Ventricles , J Neurosurg 20:1050-1063 ( (Dec) ) 1963;.
Hochwald, G.M., et al:  Cerebrospinal Fluid Production and Histological Observations in Animals With Experimental Obstructive Hydrocephalus , Exp Neurol , to be published.
Hochwald, G.M., and Wallenstein, M.:  Exchange of Albumin Between Blood, Cerebrospinal Fluid and Brain in the Cat , Amer J Physiol 212:1199-1204 ( (May) ) 1967;.
Schreiner, G.E.:  Determination of Inulin by Means of Resorcinol , Proc Soc Exp Biol Med 74:117-120 ( (May) ) 1950;.
Cutler, R.W.P.; Robinson, R.J.; and Lorenzo, A.V.:  Cerebrospinal Fluid Transport of Sulfate in the Cat , Amer J Physiol 214:448-454 ( (March) ) 1968;.
Heisey, S.R.; Held, D.; and Pappenheimer, J.R.:  Bulk Flow and Diffusion in the Cerebrospinal Fluid System of the Goat , Amer J Physiol 203:775-781 ( (May) ) 1962;.
Pappenheimer, J.R., et al:  Perfusion of the Cerebral Ventricular System in Unanesthetized Goats , Amer J Physiol 203:763-774 ( (May) ) 1962;.
Calhoun, M.C., et al:  Rates of Formation and Absorption of Cerebrospinal Fluid in Holstein Male Calves , Univ Conn Coll Agr Exp Sta Bull 401:22 ( (Feb) ) 1967;.
Cutler, R.W.P., et al:  Formation and Absorption of Cerebrospinal Fluid in Man , Brain 91:707-720 ( (Dec) ) 1968;.
Hochwald, G.M., and Wallenstein, M.C.:  Exchange of υ-Globulin Between Blood, Cerebrospinal Fluid and Brain in the Cat , Exp Neurol 19:115-126 ( (Sept) ) 1967;.
Cutler, R.W.P., and Lorenzo, A.V.:  Transport of L-Aminocyclopentanecarboxylic Acid From Feline Cerebrospinal Fluid , Science 161:1363 ( (Sept) ) 1968;.
Davson, H., and Spaziani, E.:  The Blood-Brain Barrier , J Physiol 149:135-143 ( (Dec) ) 1959;.
Rosomoff, H.L.:  Method for Simultaneous Quantitative Estimation of Intracranial Contents , J Appl Physiol 16:395-396 ( (March) ) 1961;.
Geschwind, N.:  The Mechanism of Normal Pressure Hydrocephalus , J Neurol Sci 7:481-493 ( (Nov-Dec) ) 1968;.

Correspondence

CME Course for:


You need to register in order to view this quiz.


To understand the clinical management of acute heart failure syndromes.
Accreditation Information The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
To view and print your certificate and access a summary of your CME courses go to My CME.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s “Cited By” API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.