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Commentary in Neurology |

Stroke and Alzheimer Disease Fellow Travelers or Partners in Crime?

Vladimir Hachinski, MD, DSc
Arch Neurol. 2011;68(6):797-798. doi:10.1001/archneurol.2011.118.
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One in 3 of us will have a stroke, dementia, or both, unless we improve prevention. Although cerebrovascular disorders and Alzheimer disease tend to occur together, they are studied apart and late in their evolutions, when less or little can be done.

Elias  MFBeiser  AWolf  PAAu  RWhite  RFD’Agostino  RB The preclinical phase of Alzheimer disease: a 22-year prospective study of the Framingham Cohort. Arch Neurol 2000;57 (6) 808- 813
PubMed Link to Article[[XSLOpenURL/10.1001/archneur.57.6.808]]
Jin  YPDi Legge  SOstbye  TFeightner  JWHachinski  V The reciprocal risks of stroke and cognitive impairment in an elderly population. Alzheimers Dement 2006;2 (3) 171- 178
PubMed Link to Article[[XSLOpenURL/10.1016/j.jalz.2006.03.006]]
Whitehead  SNCheng  GHachinski  VCCechetto  DF Progressive increase in infarct size, neuroinflammation, and cognitive deficits in the presence of high levels of amyloid. Stroke 2007;38 (12) 3245- 3250
PubMed Link to Article[[XSLOpenURL/10.1161/STROKEAHA.107.492660]]
Hachinski  VIadecola  CPetersen  RC  et al.  National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards. Stroke 2006;37 (9) 2220- 2241
PubMed Link to Article[[XSLOpenURL/10.1161/01.STR.0000237236.88823.47]]
Oveisgharan  SHachinski  V Hypertension, executive dysfunction, and progression to dementia: the Canadian Study of Health and Aging. Arch Neurol 2010;67 (2) 187- 192
Hachinski  V Shifts in thinking about dementia. JAMA 2008;300 (18) 2172- 2173
PubMed Link to Article[[XSLOpenURL/10.1001/jama.2008.525]]
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Patients with cognitive impairment and stroke. Based on data from Jin et al.2

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