Details of the model structure and the associated assumptions can be found in the eAppendix, eTable, and eFigure. In brief, the model consists of states that correspond to disease risk, in which simulated patients can experience any combination of “events” (eg, ischemic stroke, MI, or ICH), which may lead to increased risk of future events, change in quality of life, or death. Values for risk, outcomes, and quality of life are adopted from a recent systematic review of statin therapy1 and a previously reported decision analysis.9 Quality-of-life adjustment factors were used to account for the relative decrease in quality of life following cardiac and cerebral ischemic events.1 Risks for recurrent ICH after prior deep or lobar ICH were taken from previously reported studies.5,6 The relative risk (RR) of ICH on statin therapy from the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) trial analysis was 1.68 (95% confidence interval, 1.09-2.59); this risk was assumed to apply to both deep and lobar ICH. Event probabilities, RRs, and quality-of-life adjustment factors pertaining to the base case are summarized in Table 1. A model schematic, as well as further details, can be found in the eFigure and eAppendix.