0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Book Reviews |

Golgi: A Biography of the Founder of Modern Neuroscience

Lawrence S. Sherman, PhD; Stephen A. Back, MD, PhD
Arch Neurol. 2011;68(4):538-539. doi:10.1001/archneurol.2011.33.
Text Size: A A A
Published online

Extract

Can someone who made a remarkable series of seminal discoveries about the structure of the nervous system but who steadfastly refused to consider alternative interpretations of his data be considered the founder of modern neuroscience? This question is a central theme of Golgi: A Biography of the Founder of Modern Neuroscience by Paolo Mazzarello, recently translated into English by Aldo Badiani and Henry A. Buchtel. In 1906, Camillo Golgi and Ramon y Cajal shared the Nobel Prize for their work on the histology of the nervous system. Golgi had developed a revolutionary staining technique (“the dark reaction”) and used it on sections of nervous system tissues to demonstrate the detailed structure of neurons and glial cells with a resolution never before achieved. He clearly showed the relationship between dendrites, the neuron cell body, and axons. Nevertheless, Ramon y Cajal proposed individual neurons to be the fundamental cellular units of the nervous system and that signals traveled from 1 neuron to another (the “neuron doctrine”), whereas Golgi remained convinced that the complexity of human behavior and emotions could not be explained by such a simplistic model. Despite emerging evidence to the contrary, he steadfastly maintained that communication in the central nervous system was mediated via a “diffuse nerve network” model whereby nerve cells were physically interconnected and, in effect, communicated in a manner reminiscent of spreading waves of electrical activity that would activate broad neural networks. The neuron doctrine of Cajal would not be formally confirmed until the advent of electron microscopy, although hints from peripheral nerve regeneration, embryological analyses, and early tissue culture experiments performed during Golgi's lifetime in the late 19th and early 20th centuries challenged Golgi's reticular model of the nervous system. Only recently has the emergence of the columnar organization of the cortex and neural network theory provided some credence to Golgi's notion that higher cerebral functions must require more complex neuronal interactions.

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

17 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();