Financial Disclosure: Dr Polman has received consulting fees from Actelion, Biogen Idec, Bayer Schering Pharma AG, Teva, Merck-Serono, Novartis, GlaxoSmithKline, UCB, Roche, and Antisense Therapeutics; lecture fees from Biogen Idec, Bayer Schering Pharma AG, Novartis, and Teva; and grant support from Biogen Idec, Bayer Schering Pharma AG, GlaxoSmithKline, Novartis, UCB, Merck-Serono, and Teva. Dr Freedman has received honoraria from Bayer Schering Pharma AG, Biogen Idec, Bioms, Teva, Merck-Serono, Novartis, Sanofi-Aventis, and Pfizer and has served as a consultant on steering committees for Bayer Schering Pharma AG, Merck-Serono, Bioms, Sanofi-Aventis, and Novartis. Dr Hartung has received compensation for serving on a scientific advisory board and honoraria for lectures or consultancies from Biogen Idec, Teva, Sanofi-Aventis, Octapharma GmbH, Novartis, CSL Behring GmbH, and Merck-Serono. Dr Miller has received research grant support through his employer, University College London Institute of Neurology, for performing central MR imaging analysis in MS trials from GlaxoSmithKline, Biogen Idec, and Novartis; he has received honoraria through payments to University College London Institute of Neurology for advisory committee or consultancy advice in MS studies from Biogen Idec, GlaxoSmithKline, and Bayer Schering Pharma AG. Dr Miller served on the steering committee of the trial reported herein. Dr Montalban has received honoraria for speaking at scientific meetings and grants to travel to scientific events from Bayer Schering Pharma AG, Teva, Merck-Serono, Sanofi-Aventis, and Novartis; he has been involved in steering committees for Teva, Merck-Serono, Novartis, and Almirall. Dr Sandbrink is a salaried employee of Bayer Schering Pharma AG, which sponsored the clinical study reported herein, and he owns stock options in that company. Dr Barkhof has received compensation for consultancy or committee membership or lecture fees from Bayer Schering Pharma AG, Merck-Serono, Sanofi-Aventis, AstraZeneca, Genentech, Novartis, Biogen Idec, Active Biotech, European Charcot Foundation, Lundbeck, Talecris, Roche, UCB, Wyeth, and Medicinova Inc.