CohenArticle reviews emerging agents currently under investigation to treat relapsing multiple sclerosis that have shown promise in phase 2 trials.
Lister and BarnesArticle cover the major age-related alterations in the hippocampus, a critical structure for learning and memory.
Reitz and colleagues Article conclude that in stroke research, sensitive neuroimaging techniques, rather than stroke self-reporting, should be used to determine stroke history. Article
Lebrun et alArticle provide a longitudinal follow-up of patients with subclinical demyelinating lesions who are asymptomatic. A total of 33% had clinical conversion, with a variety of demyelinating lesions, during a mean time of 5.2 years.
Turner and colleaguesArticle have correlated susceptibility loci for brain atrophy, ventricular volume, and leukoaraiosis identified by linkage analyses and show that they differ both among magnetic resonance imaging measures and between races.
Healy et alArticle report that cigarette smoke has an adverse influence on multiple sclerosis progression and accelerates conversion from a relapsing-remitting to a progressive course.
Kaplan-Meier curve for time to conversion from relapsing-remitting to secondary progressive multiple sclerosis. Smoking status was defined at study entry. Disease in current smokers progressed significantly faster than in never-smokers (P = .002). Red line indicates current smokers; green line, ex-smokers; and black line, never-smokers.
Orr and AhlskogArticle find that amiodarone, an antiarrhythmic drug prescribed commonly for atrial fibrillation and ventricular arrhythmias, infrequently causes clinically significant neurological toxicity.
Richardson and colleaguesArticle show that β-hexachlorocyclohexane (β-HCH) is associated with Parkinson disease. They show that β-HCH is more often detectible in Parkinson disease cases compared with controls or patients with Alzheimer disease.
Specific malfunctioning of the default mode network during an executive task in Parkinson disease is described by van Eimeren et al. Article
Stöllberger and colleaguesArticle describe the occurrence of atrioesophageal fistula with serious neurological complications occurring in patients who have received radiofrequency ablation for atrial fibrillation.
Chow et alArticle point out that apathy is common in patients with frontotemporal dementia and in those with Alzheimer disease. When present, it usually involves changes in affect, behavior, and cognition.
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