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Original Contribution |

Neurological Consequences of Atrioesophageal Fistula After Radiofrequency Ablation in Atrial Fibrillation FREE

Claudia Stöllberger, MD; Thomas Pulgram, MD; Josef Finsterer, MD, PhD
[+] Author Affiliations

Author Affiliations: Second Medical Department (Dr Stöllberger) and Fourth Medical Department (Dr Pulgram), Krankenanstalt Rudolfstiftung (Dr Finsterer), Wien, Austria.


Arch Neurol. 2009;66(7):884-887. doi:10.1001/archneurol.2009.105.
Text Size: A A A
Published online

Background  Radiofrequency ablation for atrial fibrillation (RAF) is an increasingly performed procedure. It is performed during cardiac surgery or percutaneously by catheter. A dangerous complication of RAF is atrioesophageal fistula (AEF), which predominantly manifests neurologically owing to food embolism. Because neurologists may not be familiar with AEF and the prognosis is dependent on a prompt diagnosis, awareness of AEF by the neurologist may play a crucial role.

Objective  To summarize for the neurologist the knowledge about fistula between the left atrium and esophagus occurring after RAF.

Design, Setting, and Patients  Using a MEDLINE search, we collected reports about AEF after RAF in 28 patients.

Main Outcome Measures  From the collected reports, the description of symptoms, diagnostic investigations, therapy, and outcome of the 28 patients were summarized.

Results  In 28 cases, AEF developed 3 to 38 days after RAF. Confusion, grand mal seizures, meningitis, focal cortical signs, and postprandial transient ischemic attacks associated with fever were the leading manifestations in 21 of 28 patients. Blood tests showed leukocytosis, elevated serum C-reactive protein levels, and thrombocytopenia. Blood cultures were frequently positive for bacteria. Lumbar puncture revealed pleocytosis, elevated protein levels, increased lactate levels, and bacteria. Diagnosis was established by thoracic contrast computed tomography. Endoscopy, insertion of nasogastric tubes, and transesophageal echocardiography were detrimental, leading to an increase in fistula size and food or air embolism. Therapy comprised surgery (n = 11) or temporary esophageal stenting (n = 1). The remaining patients died before attempted surgery or confirmation of the diagnosis. A neurological deficit persisted in 3 of the 9 surviving patients.

Conclusions  In patients with meningitis, stroke, seizures, or impaired consciousness and fever, it should be determined whether they have had a previous RAF. In cases with a history of recent RAF, AEF should be strongly considered, especially if there are also symptoms such as dysphagia or chest pain. After RAF, the patient, his or her family, and his or her treating physicians should be informed about the signs of AEF, which may occur even weeks after RAF.

Radiofrequency ablation for atrial fibrillation (RAF) is an increasingly performed procedure, applied especially in patients with paroxysmal atrial fibrillation who are classified as refractory to antiarrhythmic drug therapy. Radiofrequency ablation for atrial fibrillation is performed either during cardiac surgery as an additional procedure or as a percutaneous catheter intervention. It is associated with various complications such as pericardial effusion, pericardial tamponade, pulmonary vein stenosis or thrombosis, and left atrial wall hematoma.1

Probably the most dangerous, life-threatening complication of RAF is the development of a fistula between the left atrium and the esophagus. The fistula may initially and predominantly manifest with neurological abnormalities, and neurological abnormalities are the main cause for hospitalization of patients with this complication (Table). Neurologists may not be familiar with the clinical presentation of this rare complication. However, the prognosis of patients with a fistula is highly dependent on prompt and appropriate diagnosis and therapy. Thus, awareness of atrioesophageal fistula (AEF) by the neurologist may play a crucial role in the survival of patients with this life-threatening disease.

Table Graphic Jump LocationTable. Patients With Atrioesophageal Fistula After Surgical or Interventional Therapy of Atrial Fibrillation

The aim of this review is to summarize for the neurologist the knowledge about fistulas occurring between the left atrium and esophagus after RAF.

Using a MEDLINE search, we collected reports about fistulas between the left atrium and esophagus. We noted this in general and especially as a complication after RAF. In the search, we found 28 cases of AEF that developed after RAF.

ETIOLOGY OF FISTULA BETWEEN ESOPHAGUS AND LEFT ATRIUM

Depending on the site of the primary lesion, esophagoatrial fistula (EAF) and AEF must be differentiated.

Esophagoatrial fistula may be due to esophageal injuries such as perforation with feeding tubes, esophageal biopsies, esophageal surgery, erosion of an esophageal diverticulum into the left atrium, and carcinoma.1421 Rheumatic mitral valve disease with an enlarged left atrium and esophageal compression in association with the intake of potassium chloride tablets has been reported as a further cause of EAF.22

Atrioesophageal fistula has been described as induced by trauma such as after a gunshot wound of the chest.23 Atrioesophageal fistula after RAF may develop owing to the proximity between the left atrium and esophagus.24 Myocardial injury during RAF may also affect the esophageal wall.25 Whether reflux esophagitis, which has been reported to be associated with paroxysmal atrial fibrillation, favors the development of AEF has not yet been investigated to our knowledge.26 To reduce radiofrequency-induced tissue damage, alternative ablation techniques have been developed. However, AEF has also been reported as a complication of ablation using high-intensity focused ultrasound (Table).13

PATHOLOGIC CONSEQUENCES OF THE FISTULA

A fistula between the left atrium and esophagus may lead to severe bleeding and food emboli. One might expect hemorrhage to be more common than food emboli because at rest, left atrial pressure exceeds esophageal pressure. The lower viscosity of blood as compared with the viscosity of food would further increase the likelihood of gastrointestinal bleeding.21 However, gastrointestinal bleeding is only rarely reported (Table) and severe bleeding has not been reported in AEF.

There is a high incidence of food emboli in AEF leading to life-threatening and mostly fatal “meat and vegetable” systemic emboli and septicemia.14 Esophagoatrial fistula as a cause of embolic meningoencephalitis was first described in 1970.27 Those patients who present with more insidious symptoms likely possess the anatomical equivalent of a single-way valve, allowing esophageal contents to enter the heart while preventing blood entry into the esophagus. Further cerebral manifestations of AEF and EAF comprise abscesses as well as cerebral air and food embolism.15,17,20

EPIDEMIOLOGY

The incidence of AEF after surgical RAF is reported to be 1%.9,10 The incidence of AEF after percutaneous RAF is unknown and has been estimated to be between 0.05% and 0.2%.7,10 It is probably markedly underreported. Among the 28 reported cases listed in the Table, the mortality of patients with EAF was 68%. The mortality was 40% after surgical RAF and 80% after percutaneous RAF, and persisting neurological deficits are reported in 3 of the 9 surviving patients.2,7,10

NONNEUROLOGICAL MANIFESTATIONS

The clinical presentation of AEF includes lethargy, general weakness, fever, chest pain, dysphagia, melena, hematemesis, and sepsis (Table). The interval between the ablation procedure and the clinical manifestation of AEF varies from 3 to 38 days.

NEUROLOGICAL MANIFESTATIONS

Neurological abnormalities occur frequently in AEF (Table). They comprise confusion, grand mal seizures, meningitis, focal cortical signs, and postprandial transient ischemic attacks. These abnormalities are most frequently associated with fever. They are unspecific and may not lead the neurologist to consider a cardiac cause for the patient's symptoms, especially if there are no findings such as scars from surgery indicating a recent invasive procedure. In patients who develop neurological signs, delays in the diagnosis probably contribute to the high mortality.10

LABORATORY FINDINGS

Blood tests show leukocytosis, elevation of serum C-reactive protein levels, thrombocytopenia, and an elevated erythrocyte sedimentation rate. Blood cultures are frequently positive for bacteria. Lumbar puncture may reveal pleocytosis, elevated protein levels, increased lactate levels, and bacteria.8

DIAGNOSIS

Chest radiography or computed tomography of the chest may be diagnostic if air is visualized within the cardiac cavities or in the mediastinum, or if intravenous contrast medium enters the esophagus from the left atrium.5 Furthermore, a contrast esophagogram may show extravasation of water-soluble contrast material in communication with a pulsating chamber.2,8 Unfortunately, not all of these signs may be present in each patient and different diagnostic investigations have to be carried out in suspected cases. Application of a barium swallow study should be avoided because barium entering the circulation has detrimental consequences. Furthermore, endoscopy, insertion of nasogastric tubes, and transesophageal echocardiography should not be carried out as they may lead to an increase in fistula size as well as possible food or air embolism from inflation of air during the procedure.4,6,7,10

DIFFERENTIAL DIAGNOSIS

Endocarditis is frequently suspected in cases with signs of infection and positive blood cultures after an invasive cardiac intervention.2 Indeed, infective endocarditis at the left atrial appendage entrance, most likely induced by endocardial damage during RFA, has been described recently as a further complication of RFA and thus renders the situation even more complicated.28 It seems reasonable to consider endocarditis as a differential diagnosis and to perform transesophageal echocardiography only after AEF has been definitively excluded.

Meningitis is a further differential diagnosis. In fact, meningitis and pathologic findings of cerebrospinal fluid have been reported as a manifestation of AEF.8 These findings suggest that in patients with meningitis, the neurologist must always ask for a history of RFA. If there is a history of RFA, AEF should be strongly considered.

Embolic stroke due to recurrent atrial fibrillation may frequently be a differential diagnosis because atrial fibrillation after RAF may recur, and a fistula between the esophagus and left atrium may induce atrial fibrillation.1,19 Patients with AEF frequently present with transient ischemic attacks or stroke. Atrioesophageal fistula should be strongly considered if the events are associated with fever or occur after meals.

Epileptic seizures and confusion are frequent manifestations of AEF (Table) but may also occur simply because of fever due to other causes. Thus, in patients with seizures and confusion associated with fever, it should always be determined whether they have a history of RFA.

TREATMENT

Therapy of AEF comprises surgical resection of the necrotic parts of the esophagus and closure of the left atrium.13 Atrial laceration may be treated with a bovine pericardial patch, and the esophageal laceration may be treated with a purse-string suture.7

Stenting of the esophagus is an established procedure for interventional closure of esophageal leakages.29 It was reported to have been successful in a single patient with AEF.11 However, the safety of this procedure has to be further evaluated because endoscopy with its inherent risk of air embolism is necessary for appropriate positioning of the stent. Furthermore, with an esophageal stent, only 1 side of the fistula is closed while the left atrial side remains open.

PROGNOSIS

Atrioesophageal fistula as a complication of RAF has a high mortality. According to the published cases (Table), patients with AEF after surgical RAF have a higher chance of survival than patients with AEF after percutaneous RAF. This difference may be owing to the higher awareness of a complication if the procedure has been performed surgically as opposed to percutaneously.

In patients with meningitis, stroke, seizures, or impaired consciousness and fever, it should be determined whether they have a history of RAF. In cases with RAF, AEF should be strongly considered, especially if there are also symptoms such as dysphagia or chest pain. The diagnosis of AEF should be immediately confirmed or ruled out by chest radiography and thoracic contrast computed tomography. If the diagnosis is confirmed, therapy should be promptly carried out. Such patients are at high risk for experiencing fatal complications by investigations such as endoscopy, transesophageal echocardiography, or a barium swallow study or by insertion of nasogastric tubes, which is frequently done after admission to an intensive care unit.

If RAF is carried out, the patient, his or her family, and his or her treating physicians should be informed about the signs of the life-threatening complication of AEF, which may occur even weeks after RAF.

Correspondence: Claudia Stöllberger, MD, Krankenanstalt Rudolfstiftung, Steingasse 31/18, 1030 Wien, Austria (claudia.stoellberger@chello.at).

Accepted for Publication: February 12, 2009.

Author Contributions:Study concept and design: Stöllberger and Finsterer. Acquisition of data: Stöllberger and Finsterer. Analysis and interpretation of data: Stöllberger and Pulgram. Drafting of the manuscript: Stöllberger and Finsterer. Critical revision of the manuscript for important intellectual content: Stöllberger and Pulgram. Statistical analysis: Stöllberger. Administrative, technical, and material support: Stöllberger and Pulgram. Study supervision: Stöllberger and Finsterer.

Financial Disclosure: None reported.

Natale  ARaviele  AArentz  T  et al.  Venice Chart international consensus document on atrial fibrillation ablation. J Cardiovasc Electrophysiol 2007;18 (5) 560- 580
PubMed
Preis  ODigumarthy  SRWright  CDShepard  JA Atrioesophageal fistula after catheter pulmonary venous ablation for atrial fibrillation: imaging features. J Thorac Imaging 2007;22 (3) 283- 285
PubMed
Cummings  JESchweikert  RASaliba  WI  et al.  Brief communication: atrial-esophageal fistulas after radiofrequency ablation. Ann Intern Med 2006;144 (8) 572- 574
PubMed
Sonmez  BDemirsoy  EYagan  N  et al.  A fatal complication due to radiofrequency ablation for atrial fibrillation: atrio-esophageal fistula. Ann Thorac Surg 2003;76 (1) 281- 283
PubMed
Schley  PGülker  HHorlitz  M Atrio-oesophageal fistula following circumferential pulmonary vein ablation: verification of diagnosis with multislice computed tomography. Europace 2006;8 (3) 189- 190
PubMed
Scanavacca  MID'Ávila  AParga  JSosa  E Left atrial-esophageal fistula following radiofrequency catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 2004;15 (8) 960- 962
PubMed
Pappone  COral  HSantinelli  V  et al.  Atrio-esophageal fistula as a complication of percutaneous transcatheter ablation of atrial fibrillation. Circulation 2004;109 (22) 2724- 2726
PubMed
Ouchikhe  AMaindivide  JLe Bivic  JLRoux  LVincent  JF Atrio-oesophageal fistula after radiofrequency ablation: predominant neurological symptoms [in French]. Ann Fr Anesth Reanim 2008;27499- 501
PubMed
Doll  NBorger  MAFabricius  A  et al.  Esophageal perforation during left atrial radiofrequency ablation: is the risk too high? J Thorac Cardiovasc Surg 2003;125 (4) 836- 842
PubMed
Dagres  NKottkamp  HPiorkowski  C  et al.  Rapid detection and successful treatment of esophageal perforation after radiofrequency ablation of atrial fibrillation: lessons from five cases. J Cardiovasc Electrophysiol 2006;17 (11) 1213- 1215
PubMed
Bunch  TJNelson  JFoley  T  et al.  Temporary esophageal stenting allows healing of esophageal perforations following atrial fibrillation ablation procedures. J Cardiovasc Electrophysiol 2006;17 (4) 435- 439
PubMed
Malamis  APKirshenbaum  KJNadimpalli  S CT radiographic findings: atrio-esophageal fistula after transcatheter percutaneous ablation of atrial fibrillation. J Thorac Imaging 2007;22 (2) 188- 191
PubMed
Borchert  BLawrenz  THansky  BStellbrink  C Lethal atrioesophageal fistula after pulmonary vein isolation using high-intensity focused ultrasound (HIFU). Heart Rhythm 2008;5 (1) 145- 148
PubMed
Bell  MDTate  LGHensley  GT Esophageal-atrial fistula resulting in systemic “meat and vegetable” emboli. Am J Forensic Med Pathol 1992;13 (2) 137- 141
PubMed
Brynjolfsson  GKania  RBekeris  L Gastroesophageal cardiac fistula due to perforation of an esophagogastric anastomotic ulcer into the left atrium. Hum Pathol 1980;11 (6) 677- 679
PubMed
Cunnane  K Esophagoatrial fistula. Can J Surg 1978;21 (5) 466- 467
PubMed
Lambert  DRLlaneza  PPGaglani  RDLach  RDBeaver  WL Esophageal-atrial fistula. J Clin Gastroenterol 1987;9 (3) 345- 349
PubMed
Murphy  GFRaymond  AKScannell  JG Esophageal-atrial perforation due to recurrent esophagitis 18 years after esophageal bypass surgery. J Thorac Cardiovasc Surg 1979;78 (2) 181- 184
PubMed
Snyder  RWDumas  PRKolts  BE Esophagoatrial fistula with previous pericarditis complicating esophageal ulceration: report of two cases and a review of the literature. Chest 1990;98 (3) 679- 681
PubMed
Nadjmi  MSchäffer  RWodarz  R Cerebral arterial air embolism due to an esophago-atrial fistula seen on CT. Neuroradiology 1979;18 (2) 103- 106
PubMed
Reynolds  PWalker  FOEades  JSmith  JDLantz  PE Food embolus. J Neurol Sci 1997;149 (2) 185- 190
PubMed
Sumithran  ELim  KHChiam  HL Atrio-oesophageal fistula complicating mitral valve disease. Br Med J 1979;2 (6204) 1552- 1553
PubMed
Bliznak  JRamsey  JD Atrio-esophageal fistula secondary to gunshot wound of the chest. Mil Med 1971;136 (6) 584- 585
PubMed
Sánchez-Quintana  DCabrera  JACliment  VFarré  JMendonça  MCHo  SY Anatomic relations between the esophagus and left atrium and relevance for ablation of atrial fibrillation. Circulation 2005;112 (10) 1400- 1405
PubMed
Schmidt  MNölker  GMarschang  H  et al.  Incidence of oesophageal wall injury post-pulmonary vein antrum isolation for treatment of patients with atrial fibrillation. Europace 2008;10 (2) 205- 209
PubMed
Weigl  MGschwantler  MGatterer  EFinsterer  JStöllberger  C Reflux esophagitis in the pathogenesis of paroxysmal atrial fibrillation: results of a pilot study. South Med J 2003;96 (11) 1128- 1132
PubMed
Hojgaard  KRaaschou-Nielsen  T Oesophago-cardiac fistula: a fistula between heart and oesophagus as causative agent in the development of embolic meningo-encephalitis. Acta Pathol Microbiol Scand Suppl 1970;212 ((suppl)) 114
PubMed
Weis  SPiorkowski  CArya  ABollmann  A Septic vegetation at the left atrial appendage entrance after pulmonary vein ablation for atrial fibrillation. Europace 2008;10 (2) 215- 217
PubMed
Radecke  KLang  HFrilling  AGerken  GTreichel  U Successful sealing of benign esophageal leaks after temporary placement of a self-expanding plastic stent without fluoroscopic guidance. Z Gastroenterol 2006;44 (10) 1031- 1038
PubMed

Figures

Tables

Table Graphic Jump LocationTable. Patients With Atrioesophageal Fistula After Surgical or Interventional Therapy of Atrial Fibrillation

References

Natale  ARaviele  AArentz  T  et al.  Venice Chart international consensus document on atrial fibrillation ablation. J Cardiovasc Electrophysiol 2007;18 (5) 560- 580
PubMed
Preis  ODigumarthy  SRWright  CDShepard  JA Atrioesophageal fistula after catheter pulmonary venous ablation for atrial fibrillation: imaging features. J Thorac Imaging 2007;22 (3) 283- 285
PubMed
Cummings  JESchweikert  RASaliba  WI  et al.  Brief communication: atrial-esophageal fistulas after radiofrequency ablation. Ann Intern Med 2006;144 (8) 572- 574
PubMed
Sonmez  BDemirsoy  EYagan  N  et al.  A fatal complication due to radiofrequency ablation for atrial fibrillation: atrio-esophageal fistula. Ann Thorac Surg 2003;76 (1) 281- 283
PubMed
Schley  PGülker  HHorlitz  M Atrio-oesophageal fistula following circumferential pulmonary vein ablation: verification of diagnosis with multislice computed tomography. Europace 2006;8 (3) 189- 190
PubMed
Scanavacca  MID'Ávila  AParga  JSosa  E Left atrial-esophageal fistula following radiofrequency catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 2004;15 (8) 960- 962
PubMed
Pappone  COral  HSantinelli  V  et al.  Atrio-esophageal fistula as a complication of percutaneous transcatheter ablation of atrial fibrillation. Circulation 2004;109 (22) 2724- 2726
PubMed
Ouchikhe  AMaindivide  JLe Bivic  JLRoux  LVincent  JF Atrio-oesophageal fistula after radiofrequency ablation: predominant neurological symptoms [in French]. Ann Fr Anesth Reanim 2008;27499- 501
PubMed
Doll  NBorger  MAFabricius  A  et al.  Esophageal perforation during left atrial radiofrequency ablation: is the risk too high? J Thorac Cardiovasc Surg 2003;125 (4) 836- 842
PubMed
Dagres  NKottkamp  HPiorkowski  C  et al.  Rapid detection and successful treatment of esophageal perforation after radiofrequency ablation of atrial fibrillation: lessons from five cases. J Cardiovasc Electrophysiol 2006;17 (11) 1213- 1215
PubMed
Bunch  TJNelson  JFoley  T  et al.  Temporary esophageal stenting allows healing of esophageal perforations following atrial fibrillation ablation procedures. J Cardiovasc Electrophysiol 2006;17 (4) 435- 439
PubMed
Malamis  APKirshenbaum  KJNadimpalli  S CT radiographic findings: atrio-esophageal fistula after transcatheter percutaneous ablation of atrial fibrillation. J Thorac Imaging 2007;22 (2) 188- 191
PubMed
Borchert  BLawrenz  THansky  BStellbrink  C Lethal atrioesophageal fistula after pulmonary vein isolation using high-intensity focused ultrasound (HIFU). Heart Rhythm 2008;5 (1) 145- 148
PubMed
Bell  MDTate  LGHensley  GT Esophageal-atrial fistula resulting in systemic “meat and vegetable” emboli. Am J Forensic Med Pathol 1992;13 (2) 137- 141
PubMed
Brynjolfsson  GKania  RBekeris  L Gastroesophageal cardiac fistula due to perforation of an esophagogastric anastomotic ulcer into the left atrium. Hum Pathol 1980;11 (6) 677- 679
PubMed
Cunnane  K Esophagoatrial fistula. Can J Surg 1978;21 (5) 466- 467
PubMed
Lambert  DRLlaneza  PPGaglani  RDLach  RDBeaver  WL Esophageal-atrial fistula. J Clin Gastroenterol 1987;9 (3) 345- 349
PubMed
Murphy  GFRaymond  AKScannell  JG Esophageal-atrial perforation due to recurrent esophagitis 18 years after esophageal bypass surgery. J Thorac Cardiovasc Surg 1979;78 (2) 181- 184
PubMed
Snyder  RWDumas  PRKolts  BE Esophagoatrial fistula with previous pericarditis complicating esophageal ulceration: report of two cases and a review of the literature. Chest 1990;98 (3) 679- 681
PubMed
Nadjmi  MSchäffer  RWodarz  R Cerebral arterial air embolism due to an esophago-atrial fistula seen on CT. Neuroradiology 1979;18 (2) 103- 106
PubMed
Reynolds  PWalker  FOEades  JSmith  JDLantz  PE Food embolus. J Neurol Sci 1997;149 (2) 185- 190
PubMed
Sumithran  ELim  KHChiam  HL Atrio-oesophageal fistula complicating mitral valve disease. Br Med J 1979;2 (6204) 1552- 1553
PubMed
Bliznak  JRamsey  JD Atrio-esophageal fistula secondary to gunshot wound of the chest. Mil Med 1971;136 (6) 584- 585
PubMed
Sánchez-Quintana  DCabrera  JACliment  VFarré  JMendonça  MCHo  SY Anatomic relations between the esophagus and left atrium and relevance for ablation of atrial fibrillation. Circulation 2005;112 (10) 1400- 1405
PubMed
Schmidt  MNölker  GMarschang  H  et al.  Incidence of oesophageal wall injury post-pulmonary vein antrum isolation for treatment of patients with atrial fibrillation. Europace 2008;10 (2) 205- 209
PubMed
Weigl  MGschwantler  MGatterer  EFinsterer  JStöllberger  C Reflux esophagitis in the pathogenesis of paroxysmal atrial fibrillation: results of a pilot study. South Med J 2003;96 (11) 1128- 1132
PubMed
Hojgaard  KRaaschou-Nielsen  T Oesophago-cardiac fistula: a fistula between heart and oesophagus as causative agent in the development of embolic meningo-encephalitis. Acta Pathol Microbiol Scand Suppl 1970;212 ((suppl)) 114
PubMed
Weis  SPiorkowski  CArya  ABollmann  A Septic vegetation at the left atrial appendage entrance after pulmonary vein ablation for atrial fibrillation. Europace 2008;10 (2) 215- 217
PubMed
Radecke  KLang  HFrilling  AGerken  GTreichel  U Successful sealing of benign esophageal leaks after temporary placement of a self-expanding plastic stent without fluoroscopic guidance. Z Gastroenterol 2006;44 (10) 1031- 1038
PubMed

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