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Occurrence of Basal Ganglia Germ Cell Tumors Without a Mass FREE

Salah Almubarak, MD; Yee-Chiung Gan, FRCS; Paul Steinbok, MBBS, FRCSC; Glenda Hendson, MBBCh, FRCPC; Ken Poskitt, MDCM, FRCPC; Helen Nadel, MD, FRCPC; Karen Goddard, FRCPC, FRCP(UK); Juliette Hukin, MBBS, FRCPC
[+] Author Affiliations

Author Affiliations: Divisions of Neurology (Drs Almubarak and Hukin), Neurosurgery (Drs Gan and Steinbok), Neuropathology (Dr Hendson), Neuroradiology (Dr Poskitt), Nuclear Medicine (Dr Nadel), and Oncology (Drs Goddard and Hukin), BC Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.


Arch Neurol. 2009;66(6):789-792. doi:10.1001/archneurol.2009.74.
Text Size: A A A
Published online

ABSTRACT

Objective  To report a case series in which basal ganglia calcifications without mass effect proved to be germ cell tumors.

Design  Case series.

Setting  Tertiary care hospital.

Patients  Four patients.

Interventions  Computed tomography, magnetic resonance imaging, positron emission tomography, biopsy, chemotherapy, and radiation therapy.

Main Outcome Measures  Recognition of clinical syndrome and radiological features.

Results  All patients had progressive hemiparesis, and 1 patient also had frontal lobe dementia. Imaging demonstrated progressive asymmetric signal abnormality with basal ganglia calcification and associated brainstem atrophy. Fludeoxyglucose F 18–positron emission tomography showed hypometabolism in contrast to malignant glioma.

Conclusion  Germ cell tumor should be considered in patients with an indolently progressive neurological course, particularly if basal ganglia calcification is present with or without enhancement, asymmetric brain atrophy, or a mass.

Figures in this Article

From 4% to 12% of all pediatric central nervous system tumors1 in the Asian population are germinomas. The incidence in the Western world is much lower at 1% but is increasing, which may in part be explained by immigration trends. From 76% to 90% of germinomas develop in the midline, mainly in the pineal and suprasellar regions,2 but occurrence in the basal ganglia (BG) and thalamus has also been documented1 in up to 8% of all intracranial germinomas in Asian populations. Patients with central nervous system germinomas arising outside the pineal or suprasellar regions may present with nonspecific symptoms and signs and subtle radiologic findings, which may delay diagnosis unless a high level of consideration is maintained.3 We describe a series of children with atypical germ cell tumors (GCTs) presenting with BG calcifications without mass effect and with or without atrophy of the cerebral peduncle.

REPORT OF CASES

PATIENT 1

An 11-year-old Chinese boy presented with a 2-year progressive history of academic decline and behavioral dysfunction. He was presumed to have attention-deficient/hyperactivity syndrome and had been administered dextroamphetamine sulfate as treatment. Neurological evaluation revealed left hemiparesis and hemiatrophy of the right pons and cerebral peduncle and calcification of the right caudate nucleus (Figure 1). This was interpreted as the result of a remote insult. For 6 months, frontal lobe dementia, progressive hemiparesis, and ataxia developed.

Place holder to copy figure label and caption
Figure 1.

Patient 1. Axial magnetic resonance images of the brain and positron emission tomographic scan. Atrophy of the right pons and cerebral peduncle (arrow on first 3 images) and right frontal hypometabolism (arrow on last image) are seen. This patient was subsequently proven to have germinoma based on the results of the biopsy.

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Follow-up magnetic resonance imaging (MRI) with contrast media showed increased signal changes in the white matter of the right hemisphere, right cerebellum, and left internal capsule, with progressive right frontal white matter loss without mass effect or enhancement. This was interpreted as multifocal progressive white matter disorder. Positron emission tomography with fludeoxyglucose F 18 (FDG-PET) showed right frontal decreased activity. Test results for serum and cerebrospinal fluid (CSF) tumor markers were normal, and findings from the cytologic examination were negative. Right frontal lobe biopsy revealed germinoma (Figure 2). The patient received 6 cycles of carboplatin-based chemotherapy followed by 20 Gy (to convert to rad, multiply by 100) of craniospinal radiation. The hemiparesis and ataxia resolved; however, he had persistent, although improved, cognitive impairment 30 months later.

Place holder to copy figure label and caption
Figure 2.

Patient 1. Right frontal lobe biopsy examinations. A, Germinoma cells in deep cortex and superficial white matter (hematoxylin-eosin, original magnification ×25). B, Germinoma cells (placental alkaline phosphatase–positive, original magnification ×50). C, Germinoma cells with prominent nuclei and clear cytoplasm (hematoxylin-eosin, original magnification ×400).

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PATIENT 2

A 9-year-old Tongan boy presented with static mild mental handicap and progressive hemiparesis of 6 months' duration. Computed tomographic scanning showed calcification of the left BG extending to the midbrain without mass effect (Figure 3). The left cerebral peduncle and pons were slightly smaller than those on the opposite side, suggesting atrophy. There was no dissemination. Based on the results of computed tomographic scanning with contrast (in particular, the BG calcification and secondary wallerian degeneration) and on our previous experience, GCT was considered. His CSF chorionic gonadotrophin, β subunit, level was 11 mIU/mL (normal range, 0-5 mIU/mL) (to convert to international units per liter, multiply by 1.0). Stereotactic biopsy of the BG lesion confirmed germinoma. He received carboplatin, cisplatin, and etoposide, followed by focal radiotherapy.

Place holder to copy figure label and caption
Figure 3.

Patient 2. Axial computed tomographic brain scans. Calcified changes are seen in the left basal ganglia, thalamus, cerebral peduncle, and internal capsule (arrows). This patient was subsequently proven to have germinoma based on the results of the biopsy.

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PATIENT 3

A 6½-year-old white girl presented with headache and panhypopituitarism. She had a suprasellar mass, and tests for tumor markers were normal, and the results of the biopsy showed germinoma. She had a complete response to 2 cycles of carboplatin and etoposide. This was followed by focal radiotherapy with 30.6 Gy. One year later, progressive right hemiparesis, emotional lability, and dysarthria developed during a 5-month period. Computed tomographic scanning and MRI with contrast media suggested new neuronal tissue damage and calcification involving the left posterior limb of the internal capsule and lentiform nucleus. Chorionic gonadotropin, β subunit, and α-fetoprotein (AFP) levels were normal in CSF, and serum AFP was 16 ng/mL (normal range, 0-11 ng/mL) (to convert to micrograms per liter, multiply by 1.0). The FDG-PET scan showed decreased uptake. She received hyperbaric oxygen, but the hemiparesis worsened, serum AFP increased to 37 ng/mL, and progression was noted on MRI with mass effect. She was diagnosed as having recurrent malignant GCT, and chemotherapy was commenced with a reduction in AFP. On chemotherapy, status epilepticus secondary to hyponatremia developed. Chemotherapy was stopped on parental request. She died of progressive tumor 2 months later.

PATIENT 4

A 13-year-old white boy underwent a total resection of a third ventricular tumor, consisting of immature teratoma with a small focus of germinoma. Test results for tumor markers in serum and CSF were normal. He received focal radiotherapy of 41.4 Gy. At age 21, progressive right hemiparesis developed. Computed tomographic scanning and MRI revealed bilateral BG calcification with regional enhancement extending into the left cerebral peduncle without mass effect. Injury secondary to previous radiation was the primary differential rather than tumor recurrence in the absence of mass effect. Eight months later, he was dysarthric and more hemiparetic. Magnetic resonance imaging showed a mass in the left BG and thalamus extending to the midbrain. Test results were negative for AFP and chorionic gonadotropin, β subunit, levels in serum and CSF and positive for c-kit. The results of the biopsy examination demonstrated a germinoma. The patient received 2 cycles of high-dose chemotherapy (etoposide, cyclophosphamide, and carboplatin) and then fractionated stereotactic focal radiotherapy of 36.2 Gy. He is stable at 4-year follow-up.

Systemic workup for GCT was performed in patients 1, 2, and 3, and the results were normal. The patients were not immunocompromised at presentation of BG GCTs, and brain biopsy did not reveal any evidence of viral infection, including John Cunningham virus.

COMMENT

The MRI findings of typical pineal and suprasellar intracranial germinomas are a mass with signal intensity similar to adjacent cerebral tissue on both T1- and T2-weighted images with intense homogeneous contrast enhancement.4 Tumor calcification on computed tomography is reported in up to 50% of patients.5 The imaging appearance in germinomas outside the pineal and suprasellar regions consists of isodense or hyperdense lesions with heterogeneous enhancement in the solid component and associated cysts and calcification.1

In germinomas of the BG and thalamus, the radiologic findings are usually subtle initially. Cerebral atrophy of the brainstem and ipsilateral cerebral hemisphere might be the only abnormal finding, along with nonspecific increased signal changes in the cerebral white matter. The incidence of cerebral atrophy ranges between 20% and 33%.6,7 The cerebral atrophy is hypothesized to be due to either infiltration of tumor cells into the internal capsule or involvement of thalamic ganglionic cells, with infiltration of afferent and efferent nerve fibers from the thalamus and subsequent antegrade and retrograde wallerian degeneration.8 As the tumor progresses, it may produce mass effect, but, if the process is diffusely infiltrative, it may cause progressive atrophy as occurred in patient 1. Heterogeneity on T1- and T2-weighted magnetic resonance images are also more commonly seen in atypical germinomas, reflecting concomitant solid and cystic portions of the tumor.4

The indolent progression of germinomas occurring outside the pineal and suprasellar areas has commonly resulted in delayed diagnosis, as was the case in 3 of our 4 patients.1,9 The progressive neurological dysfunction and dementia in patient 1 raised the possibility of a neurodegenerative disorder, a tumor, progressive vasculopathy, or chronic encephalitis. The lack of mass effect associated with the BG lesion and the atrophy of the cerebral peduncle suggested a diagnosis other than tumor. Similar radiologic findings for patient 2 were interpreted correctly because of our experience with patient 1.

Positron emission tomography with FDG measures metabolic activity of tumors, with malignant tumors having increased FDG uptake; benign tumors and radiation necrosis demonstrate reduced uptake.10 Our 2 patients (patients 1 and 3) showed FDG-PET hypometabolism, which, to our knowledge, has not been previously described in relation to GCT. Slow-growing, infiltrative GCTs might be interpreted as nonmalignant lesions on FDG-PET if this clinical entity is not recognized. Other PET tracers such as carbon 11–labeled methionine that show hypermetabolism in the presence of tumor used in conjunction with FDG-PET might be more useful in accurately diagnosing this intracranial tumor. As yet, this tracer is not as readily available as FDG.

This case series suggests that indolently progressive neurological deficits with hemiparesis with unilateral or asymmetric calcification of the BG and thalamus with or without cerebral peduncle atrophy should raise the consideration of primary or recurrent GCT. The differential diagnosis of symmetric BG calcification includes remote infection, metabolic or endocrine disorder, and toxins.11 Calcification with volume loss suggests a destructive process: degenerative disease, a remote injury, GCT, or vasculopathy. The latter possibilities are more likely to be unilateral or asymmetric unless they are the result of a global remote injury such as whole-brain radiotherapy. Calcification with a mass raises the possibility of several tumor types12 (Table), a granulomatous process, or cysticercosis. The incidence of radiation-induced vasculopathy or calcification increases with larger total radiation dose, fraction size and volume of the treated nervous system, young age, and adjuvant methotrexate. It can occur as early as 3 months or many years following the radiation exposure. In delayed radiation necrosis, computed tomographic scanning reveals a low-density white matter lesion with heterogeneous enhancement, mass effect, and occasional calcification. There is increased T2 signal on MRI. Clearly, the development of bilateral or unilateral BG calcification postradiation for GCT can represent either radiation toxicity or relapse. Based on this series and other reports in the literature, an unequivocal diagnosis cannot be made radiographically and a biopsy should be considered early. Similarly, in the presence of an indolently progressive neurological disorder with unilateral calcification of the BG, even when there is no mass effect or atrophy of the cerebral peduncle, GCT should be in the differential diagnosis and a biopsy should be considered early to identify this treatable disease.

Table Graphic Jump LocationTable. Causes of Basal Ganglia Calcification

CONCLUSION

Intracranial GCTs must be considered in those presenting with indolently progressive neurological dysfunction, with asymmetric progressive brain abnormalities. Atypical GCTs may cause calcification in BG and atrophy of the ipsilateral cerebral hemisphere and midbrain. An FDG-PET scan of BG GCTs demonstrates hypometabolism in contrast to malignant gliomas. It is important to diagnose GCTs before the development of major neurological deficits, because delayed treatment results in irreversible neurological dysfunction.

ARTICLE INFORMATION

Correspondence: Juliette Hukin, MBBS, FRCPC, Division of Neurology, British Columbia Children's Hospital, K3-147, 4480 Oak St, Vancouver, BC, V6H 3V4 Canada (jhukin@cw.bc.ca).

Accepted for Publication: August 22, 2008.

Author Contributions: Drs Steinbok, Poskitt, and Hukin had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Gan, Steinbok, and Hukin. Acquisition of data: Almubarak, Steinbok, Hendson, Poskitt, Nadel, Goddard, and Hukin. Analysis and interpretation of data: Steinbok, Hendson, Poskitt, Nadel, and Hukin. Drafting of the manuscript: Gan, Poskitt, and Hukin. Critical revision of the manuscript for important intellectual content: Almubarak, Gan, Steinbok, Hendson, Poskitt, Nadel, Goddard, and Hukin. Administrative, technical, and material support: Almubarak, Gan, Poskitt, and Nadel. Study supervision: Gan, Steinbok, and Hukin.

Financial Disclosure: None reported.

REFERENCES

Tamaki  NLin  TShirataki  K  et al.  Germ cell tumors of the thalamus and the basal ganglia. Childs Nerv Syst 1990;6 (1) 3- 7
PubMed Link to Article
Sumida  MUozumi  TKiya  K  et al.  MRI of intracranial germ cell tumours. Neuroradiology 1995;37 (1) 32- 37
PubMed Link to Article
Okamoto  KIto  JIshikawa  K  et al.  Atrophy of the basal ganglia as the initial diagnostic sign of germinoma in the basal ganglia. Neuroradiology 2002;44 (5) 389- 394
PubMed Link to Article
Kim  DIYoon  PHRyu  YHJeon  PHwang  GJ MRI of germinomas arising from the basal ganglia and thalamus. Neuroradiology 1998;40 (8) 507- 511
PubMed Link to Article
Rushing  EJSandberg  GDJudkins  AR  et al.  Germinoma: unusual imaging and pathological characteristics: report of two cases. J Neurosurg 2006;104 (2) ((suppl)) 143- 148
PubMed Link to Article
Kim  CHPaek  SHPark  IAChi  JGKim  DG Cerebral germinoma with hemiatrophy of the brain: report of three cases. Acta Neurochir (Wien) 2002;144 (2) 145- 150
PubMed Link to Article
Sartori  SLaverda  AMCalderone  M  et al.  Germinoma with synchronous involvement of midline and off-midline structures associated with progressive hemiparesis and hemiatrophy in a young adult. Childs Nerv Syst 2007;23 (11) 1341- 1345
Link to Article
Ozelame  RVShroff  MWood  B  et al.  Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy. Pediatr Radiol 2006;36 (4) 325- 330
PubMed Link to Article
Komatsu  YNarushima  KKobayashi  E  et al.  CT and MR of germinoma in the basal ganglia. AJNR Am J Neuroradiol 1989;10 (5) ((suppl)) S9- S11
PubMed
Borgwardt  LHøjgaard  LCarstensen  H  et al.  Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion. J Clin Oncol 2005;23 (13) 3030- 3037
PubMed Link to Article
Ho  VBFitz  CRChuang  SHGeyer  CA Bilateral basal ganglia lesions: pediatric differential considerations. Radiographics 1993;13 (2) 269- 292
PubMed Link to Article
Shaikh  Z Central nervous system complications of radiation. Neurology Medlink web site. http://www.medlink.com/medlinkcontent.asp. Accessed January 24, 2009

Figures

Place holder to copy figure label and caption
Figure 1.

Patient 1. Axial magnetic resonance images of the brain and positron emission tomographic scan. Atrophy of the right pons and cerebral peduncle (arrow on first 3 images) and right frontal hypometabolism (arrow on last image) are seen. This patient was subsequently proven to have germinoma based on the results of the biopsy.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Patient 1. Right frontal lobe biopsy examinations. A, Germinoma cells in deep cortex and superficial white matter (hematoxylin-eosin, original magnification ×25). B, Germinoma cells (placental alkaline phosphatase–positive, original magnification ×50). C, Germinoma cells with prominent nuclei and clear cytoplasm (hematoxylin-eosin, original magnification ×400).

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Patient 2. Axial computed tomographic brain scans. Calcified changes are seen in the left basal ganglia, thalamus, cerebral peduncle, and internal capsule (arrows). This patient was subsequently proven to have germinoma based on the results of the biopsy.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable. Causes of Basal Ganglia Calcification

References

Tamaki  NLin  TShirataki  K  et al.  Germ cell tumors of the thalamus and the basal ganglia. Childs Nerv Syst 1990;6 (1) 3- 7
PubMed Link to Article
Sumida  MUozumi  TKiya  K  et al.  MRI of intracranial germ cell tumours. Neuroradiology 1995;37 (1) 32- 37
PubMed Link to Article
Okamoto  KIto  JIshikawa  K  et al.  Atrophy of the basal ganglia as the initial diagnostic sign of germinoma in the basal ganglia. Neuroradiology 2002;44 (5) 389- 394
PubMed Link to Article
Kim  DIYoon  PHRyu  YHJeon  PHwang  GJ MRI of germinomas arising from the basal ganglia and thalamus. Neuroradiology 1998;40 (8) 507- 511
PubMed Link to Article
Rushing  EJSandberg  GDJudkins  AR  et al.  Germinoma: unusual imaging and pathological characteristics: report of two cases. J Neurosurg 2006;104 (2) ((suppl)) 143- 148
PubMed Link to Article
Kim  CHPaek  SHPark  IAChi  JGKim  DG Cerebral germinoma with hemiatrophy of the brain: report of three cases. Acta Neurochir (Wien) 2002;144 (2) 145- 150
PubMed Link to Article
Sartori  SLaverda  AMCalderone  M  et al.  Germinoma with synchronous involvement of midline and off-midline structures associated with progressive hemiparesis and hemiatrophy in a young adult. Childs Nerv Syst 2007;23 (11) 1341- 1345
Link to Article
Ozelame  RVShroff  MWood  B  et al.  Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy. Pediatr Radiol 2006;36 (4) 325- 330
PubMed Link to Article
Komatsu  YNarushima  KKobayashi  E  et al.  CT and MR of germinoma in the basal ganglia. AJNR Am J Neuroradiol 1989;10 (5) ((suppl)) S9- S11
PubMed
Borgwardt  LHøjgaard  LCarstensen  H  et al.  Increased fluorine-18 2-fluoro-2-deoxy-D-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion. J Clin Oncol 2005;23 (13) 3030- 3037
PubMed Link to Article
Ho  VBFitz  CRChuang  SHGeyer  CA Bilateral basal ganglia lesions: pediatric differential considerations. Radiographics 1993;13 (2) 269- 292
PubMed Link to Article
Shaikh  Z Central nervous system complications of radiation. Neurology Medlink web site. http://www.medlink.com/medlinkcontent.asp. Accessed January 24, 2009

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