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Error in Figure in: Episodic Ataxia Associated With EAAT1 Mutation C186S Affecting Glutamate Reuptake

Arch Neurol. 2009;66(4):497. doi:10.1001/archneurol.2009.68.
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Error in Figure. In the Original Contribution entitled “Episodic Ataxia Associated With EAAT1 Mutation C186S Affecting Glutamate Reuptake,” by de Vries et al, published in the January issue of the Archives (2009;66[1]:97-101), incorrect y-axis length and labeling appears in Figure 2C. The y-axis now extends to a value of 120 and should read as follows: “Glutamate Uptake (pmol/mg protein/min).” The corrected Figure 2C appears here.

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Figure 2.

EAAT1 C186S mutation. A, Schematic representation of the EAAT1 protein and the location of the mutated Cys186 amino acid in transmembrane segment 4B (indicated by a black dot) (the structure is adapted from Yernool et al14). B, Conservation of the mutated residue Cys186 highlighted in gray. The protein sequences were obtained from GenBank (homo sapiens, NP_004163; Bos taurus, NP_683740; Mus musculus, NP_683740; Rattus norvegicus, NP_062098; salamander, O57321; Danio rerio, NP_997805; Drosophila melanogaster, NP_477428; human EAAT2, AY066021; human EAAT3, NP_004161; human EAAT4, NP_005062; human EAAT5, NP_006662). C, Glutamate uptake assay in COS7 cells expressing mutant EAAT1-186S (mean [SEM], 88.2 [5.5]) or wild-type EAAT1-186C (mean [SEM], 107.8 [6.9]). The results are the mean (SEM) of the 4 experiments, each in triplicate. The values are picomoles of glutamate transported per milligram of protein per minute of incubation. Asterisk indicates significant reduction of glutamate uptake compared with wild type (P = .029). Error bars indicate SEM. HP indicates helical hairpin.

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