0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Images in Neurology |

Giant Cell Tumor of the Sphenoid

Maria Margarita Company, MD; Rafael Ramos, MD
Arch Neurol. 2009;66(1):134-135. doi:10.1001/archneurol.2008.509.
Text Size: A A A
Published online

Extract

A 19-year-old man was seen for progressive visual loss and exophthalmia of the left eye occurring over a period of 5 months. Ophthalmologic examination showed decreased visual acuity of the left eye and mild visual field abnormalities. The remaining neurological examination was normal. Cranial magnetic resonance imaging showed an enhancing tumor at the junction of the orbital apex, ethmoidal sinus, and sphenoid sinus that extended intracranially toward the left frontal and temporal lobes and toward the ethmoid sinus, infiltrating the sphenoid fissure, otic canal, and cavernous sinus (Figure 1). A craniotomy was carried out through a left frontotemporal approach, with resection of the intracranial component. Microscopic examination revealed a tumor composed of multinucleated giant cells, stromal cells, aggregates of foamy histiocytes, and hemorrhagic foci (Figure 2). Mitoses were scarce. A diagnosis of giant cell tumor (GCT) of the sphenoid bone was established. The patient presented recurrent disease at 2 months following the intervention. Imaging studies showed tumor growth toward the temporal lobe, invasion of the cavernous sinus, and persistence of the sphenoid and ethmoid mass. The patient underwent a second procedure with confirmation of the histopathological diagnosis. At the time of writing this article, he had sequelae of ophthalmoplegia of the left eye associated with palpebral ptosis and amaurosis.

Figures in this Article

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption
Figure 1.

Coronal (A) and axial (B) T2-weighted magnetic resonance imaging of the skull base. An expansive intradiploic lesion is seen (arrow), slightly hyperintense on T2 imaging, with bulging and displacement of the cortical bone of the major wing of the left sphenoid. The mass encompasses the optic nerve, whereas the interface between the posterior fossa and the orbit is preserved.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

A and B, Histological study shows a tumor composed of multinucleated giant cells intermixed with ovoid stromal cells, hemorrhagic foci, and xanthomatous histiocytes (hematoxylin-eosin, original magnification ×100).

Graphic Jump Location

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

172 Views
6 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

PubMed Articles
Jobs
brightcove.createExperiences();