Author Contributions: Dr Zeviani had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Spinazzola, Santer, Schaefer, Ding, and Zeviani. Acquisition of data: Spinazzola, Santer, Akman, Tsiakas, Ding, Karadimas, Shanske, Ganesh, and Di Mauro. Analysis and interpretation of data: Spinazzola, Santer, Akman, Schaefer, Di Mauro, and Zeviani. Drafting of the manuscript: Spinazzola, Shanske, and Ganesh. Critical revision of the manuscript for important intellectual content: Santer, Akman, Tsiakas, Schaefer, Karadimas, Di Mauro, and Zeviani. Obtained funding: Ding and Zeviani. Administrative, technical, and material support: Santer, Akman, Tsiakas, Schaefer, and Karadimas. Study supervision: Spinazzola, Shanske, Di Mauro, and Zeviani.