Snare devices ensnare, incorporate, or interdigitate the thrombus and extract it through the guide catheter or sheath. Laser devices, such as the Endovascular Photo-Acoustic Recanalization (EPAR; EndoVasix, Inc, Belmont, California) system, use a microcatheter with a laser at the tip. Clot emulsification is achieved using acoustic energy generated by photo energy at the fiberoptic tip. Ultrasonographic devices, such as the MicroLysUs catheter (EKOS Corp, Bothell, Washington), are designed for augmented fibrinolysis. An ultrasound transducer is used to microfracture the embolic material and create microstreaming of the thrombolytic agent into the thrombus. These pulses help advance thrombolytic agents into the thrombus. With clot retrieval devices, such as the MERCI Retrieval System (Concentric Medical, Inc), the guidewire and microcatheter are placed beyond the clot, the retriever engages and ensnares the clot, the balloon is inflated, and the clot is pulled into the catheter and removed. In suction thrombectomy, a catheter is navigated over a guidewire into the thrombus within the internal carotid artery, and a syringe is used to aspirate the thrombus. The goal is to extract as much thrombus as possible to minimize the amount of thrombolytic agents needed to achieve recanalization. Thromboaspiration devices used in the present study included the Possis AngioJet System (Possis Medical, Inc, Minneapolis, Minnesota), which combines local vortex suction with mechanical disruption. The catheters use multiple retrograde high-pressure fluid jets directed into the primary evacuation lumen to create a hydrodynamic vortex that draws in, traps, and fragments the thrombus.