Berger and HouffArticle indicate in their highly informative discussion that the herpes viruses are clearly responsible for significant neurological morbidity. Importantly, 3 of the 8 human herpes viruses, herpes simplex virus type 1 (HSV-1), HSV-2, and varicella zoster virus, establish latency in the peripheral sensory ganglia and persist in the host throughout his or her lifetime. Clinical syndromes, diagnostic criteria, and current therapies are incisively reviewed. They emphasize that up to 45 million people in the United States have been infected with HSV-2, and the estimated incidence of new infection is 1 million annually. Their review provides an overview of the neurological complications of HSV-2.