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Ocular Flutter, Generalized Myoclonus, and Trunk Ataxia Associated With Anti-GQ1b Antibodies FREE

Olivier Zaro-Weber, MD; Norbert Galldiks, MD; Christian Dohmen, MD; Gereon R. Fink, MD, PhD; Dennis A. Nowak, MD, PhD
[+] Author Affiliations

Author Affiliations: Department of Neurology, University of Cologne, Cologne, Germany.


Arch Neurol. 2008;65(5):659-661. doi:10.1001/archneur.65.5.659.
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Published online

ABSTRACT

Objective  To describe a movement disorder characterized by ocular flutter, trunk ataxia, and mild generalized myoclonus associated with anti-GQ1b antibodies.

Design  Case report.

Setting  University hospital.

Patient  A 37-year-old woman presented with rapid, conjugated, and periodic oscillations of the eyes with a strict preponderance for the horizontal plane (ocular flutter); trunk ataxia; and occasional arrhythmic muscle jerks (myoclonus) most pronounced at the neck.

Results  Brain magnetic resonance imaging results were normal. Cerebrospinal fluid examination revealed mild lymphocytic pleocytosis. Results of extensive serological tests on viral, bacterial, and fungal infections from blood and cerebrospinal fluid samples were unremarkable. Results of screening examinations for neoplasms and paraneoplastic antibodies, including whole-body fludeoxyglucose F18 positron emission tomography, were normal. Positive titers of IgG and IgM anti-GQ1b antibodies were found.

Conclusions  This is the first description of an association between the clinical syndrome of ocular flutter, mild stimulus sensitive myoclonus, and trunk ataxia and anti-GQ1b antibodies. The association with ganglioside antibodies lends further support to the notion of an autoimmune-associated pathology of the syndrome.

Figures in this Article

Ocular flutter is a rare oculomotor syndrome that is clinically defined by intermittent bursts of involuntary conjugate eye oscillations with a strict preponderance for the horizontal plane and without intersaccadic interval.1 Ocular flutter has been considered to be a subform of opsoclonus, probably caused by a loss of tonic stimulation of omnipause neurons.2 In the healthy brain, omnipause neurons inhibit burst neurons within the paramedian pontine reticular formation responsible for conjugate horizontal eye movements and cease to discharge before and during saccadic eye movements.2 Although our current understanding of the pathophysiology of ocular flutter is incomplete, this syndrome appears to originate from a loss of omnipause neuron inhibition on burst neurons within the paramedian pontine reticular formation.1,2 A recent case of ocular flutter after a circumscribed pontine lesion due to multiple sclerosis strongly supports the role of the paramedian pontine reticular formation within the current pathophysiological concept of ocular flutter.3

Cogan4 and Baringer and colleagues5 are credited for the first descriptions of a movement disorder characterized by brief jerks of conjugated eye movements and postural body tremor. Although ocular flutter and opsoclonus probably share a common pathophysiology, the syndromes are clinically distinct. Whereas the conjugate oscillations of the eyes are strictly horizontal in ocular flutter, irregular oscillations in both the horizontal and vertical planes are observed in opsoclonus.1,2 Hankey and Sadka6 reported a case of ocular flutter associated with postural body tremor and trunk ataxia. In each of these early descriptions, cerebrospinal fluid examination revealed a mild lymphocytic pleocytosis, suggesting a parainfectious origin. Despite the frequent lack of direct serological evidence, the etiology of ocular flutter has been associated with postinfectious autoimmune processes after infection with viruses,510 such as the mumps virus,5 enterovirus,8 cytomegalovirus,9 and the AIDS virus.10 However, ocular flutter has also been reported to be associated with several forms of cancer, such as breast cancer10 and small-cell lung cancer.11,12

We report a movement disorder characterized by ocular flutter, trunk ataxia, and mild generalized myoclonus associated with anti-GQ1b antibodies. Our case description strengthens the autoimmune response hypothesis of this rare syndrome.

REPORT OF A CASE

Three days before admission, a 37-year-old woman developed brief paroxysmal episodes of blurred vision, illusions of horizontal external motion (oscillopsia), dizziness, gait imbalance, and occasional arrhythmic muscle jerks (myoclonus) most pronounced at the neck. The jerks ceased when she lay down in a recumbent position and were provoked by sitting up, standing, or walking. Truncal instability was already present when sitting up. The onset of these symptoms had been preceded by a generalized feeling of discomfort, loss of appetite, and a febrile infection of the upper respiratory tract with a sore throat for 2 weeks.

Neurological examination on admission revealed periodic, rapid, conjugated oscillations of the eyes with a strict preponderance for the horizontal plane (ocular flutter). The eye oscillations were independent of eye position and occurred during fixation (voluntary and guided changes in gaze position), regardless of gaze direction, with eyes open or closed (a video is available here. The patient had full-range conjugated ocular motion and did not report diplopia. A mild-stimulus sensitive myoclonus (which was most pronounced at the neck and provoked by sitting or standing) as well as mild ataxia of the trunk and gait in the absence of limb ataxia were evident (a video is available here). The myoclonus was relieved when the patient was in a recumbent position. The remainder of the neurological examination results were unremarkable. Clinical symptom severity increased within 1 week of admission, with the horizontal eye oscillations being more frequent (a video is available here) and ataxia of the trunk and gait being more pronounced.

Red and white blood cell counts and biochemistry were normal on admission. Cerebrospinal fluid examination on admission revealed a normal opening pressure and mild pleocytosis (75 lymphocytes/mm3). Cerebrospinal fluid protein, lactate, and glucose levels were within the normal range. Oligoclonal bands were positive and quantitative cerebrospinal fluid IgG and IgM indexes were positive. Results of a cerebrospinal fluid examination repeated 10 days later were unremarkable (3 lymphocytes/mm3).

Brain magnetic resonance imaging, including 2-mm sections through the brainstem and the cerebellum, showed no abnormality before or following application of gadolinium–diethylenetriamine pentaacetic acid. Analysis of ocular movements using electrooculography revealed bursts of rapid horizontal, symmetric, and sinusoidal movements without intersaccadic interval (Figure). Results of electrophysiological examinations, such as somatosensory, acoustic, and visual evoked potentials and electroencephalography, were normal. Results of duplex Doppler ultrasonography of the extracranial and intracranial vessels were also normal.

Place holder to copy figure label and caption
Figure.

Oculographic recording showing bursts of rapid horizontal, conjugated, and sinusoidal movements without intersaccadic interval with eyes open and closed.

Graphic Jump Location

Serological tests, cultures, and polymerase chain reactions performed on blood and cerebrospinal fluid samples were negative for viral, bacterial, and fungal infections. Tests included screenings for infection with Ebstein-Barr virus, mumps, measles, rubella virus, adenovirus, influenza virus type A and B, cytomegalovirus, herpes simplex virus type 1 and 2, varicella-zoster virus, enterovirus, human immune deficiency virus type 1 and 2, Chlamydia pneumoniae, Borrelia burgdorferi, Haemophilus influenzae, Neisseria meningitis, Campylobacter jejuni, Mycoplasma pneumoniae, Yersinia, Listeria monocytogenes, Streptococcus pneumoniae, Mycobacterium tuberculosis, and Treponema pallidum.

Results of screening examinations for neoplasms, including abdominal ultrasonography, computed tomography of the abdomen and chest, as well as whole-body fludeoxyglucose F18 positron emission tomography, were all unremarkable. Serological tests of blood and cerebrospinal fluid for paraneoplastic antibodies, such as anti-Ri (ANNA-2), anti-Hu (ANNA-1), anti-Yo (PCA1), anti-Ma2, anti-CV2 (collapsin response mediator protein 5), and anti-amphiphysin, were negative. Ganglioside antibodies were negative for GM1, GM2, GM3, GD1a, GD1b, GD3, GT1a, GT1b, GT3, and asialo GM1. IgG and IgM antibodies against GQ1b were found.

The patient was initially treated with acyclovir (750 mg, 3 times a day intravenously) and ceftriaxone (2000 mg once a day intravenously) for 14 days. Prednisolone acetate (1000 mg once a day intravenously) was given to the patient for 5 days together with the antiviral and antibiotic therapy and then was switched for an oral regimen (100 mg once a day orally) for 11 days. Plasmapheresis therapy began 21 days after admission, with daily immunoadsorption of 500 mL of plasma for 2 days but had to be discontinued owing to low fibrinogen levels. Twenty-three days after admission, immunoadsorption therapy was started (3 L) for 3 days. Twenty-six days after admission, the patient was given intravenous immunoglobulins (10 g, 3 times a day for 5 days). The symptoms gradually resolved after the second day of immunoadsorption and continued to improve after the administration of intravenous immunoglobulins during the following 2 weeks.

COMMENT

This is the first description of an association between anti-GQ1b antibodies and the clinical syndrome of ocular flutter, stimulus sensitive myoclonus, and truncal ataxia. The association of ocular flutter with elevated serum titers for ganglioside antibodies lends further support to the notion of an autoimmune-associated pathology of the syndrome. The origin of ocular flutter appears to be related to a malfunction of the inhibitory control of saccadic burst neurons in the paramedian pontine reticular formation.1,2 Postural ataxia of the trunk in the absence of limb ataxia may be associated with a circumscribed dysfunction of the vestibulocerebellum, including the flocculus and the nodulus, the nucleus fastigii, the ventral uvula, and the ventral paraflocculus.7 Generalized myoclonus most likely results from a dysfunction within the Guillain-Mollaret triangle between the nucleus ruber, the inferior olive, and the dentate nucleus of the cerebellum.

It is typical of the syndrome that brain imaging does not demonstrate an anatomical lesion,511 and therefore the clinical symptomatology is probably caused by a functional rather than a structural disturbance within the network of areas specified. The brainstem and cerebellar features found in our patient suggest that anti-GQ1b antibodies target central nervous system epitopes in these neuroanatomical regions. Indeed, an association between ganglioside antibodies and central nervous brainstem malfunction causing oculomotor deficits (not cranial nerve dysfunction as obvious as in Miller-Fisher syndrome13) has recently been described.14 Generally, this syndrome has a benign course, and an appropriate treatment regimen remains to be established given its rare occurrence. Intravenous high-dose immunoglobulin and plasmapheresis have been recommended, while oral steroids are less effective.412,14 In our case, antibiotics and steroid treatment did not result in profound clinical improvement. The favorable course in many reported cases is probably caused by spontaneous remission.4,5,7 An association with anti-GQ1b antibodies should be considered when confronted with a movement disorder that is related to dysfunction of the brainstem (ocular flutter and myoclonus) and the vestibulocerebellum (trunk ataxia), and additional clinical or instrumental data suggesting other etiologies are lacking.

ARTICLE INFORMATION

Correspondence: Dennis A. Nowak, MD, PhD, Department of Neurology, University Hospital Cologne, University of Cologne, Kerpener Strasse 62, D-50924 Cologne, Germany (dennis.nowak@uk-koeln.de).

Accepted for Publication: September 20, 2007.

Author Contributions:Study concept and design: Zaro-Weber and Nowak. Acquisition of data: Zaro-Weber, Galldiks, and Dohmen. Analysis and interpretation of data: Zaro-Weber, Fink, and Nowak. Drafting of the manuscript: Zaro-Weber and Nowak. Critical revision of the manuscript for important intellectual content: Zaro-Weber, Galldiks, Dohmen, Fink, and Nowak. Administrative, technical, and material support: Zaro-Weber and Galldiks. Study supervision: Zaro-Weber, Fink, and Nowak.

Financial Disclosure: None reported.

REFERENCES

Gaymard  BPierrot  C Neurology of saccades and smooth pursuit. Curr Opin Neurol 1999;12 (1) 13- 19
PubMed Link to Article
Leigh  LJZee  DS The Neurology of Eye Movements. 3rd ed. New York, NY Oxford University Press1999;133- 144449- 456
Schon  FHodgson  TLMort  DKennard  C Ocular flutter associated with a localized lesion in the paramedian pontine reticular formation. Ann Neurol 2001;50 (3) 413- 416
PubMed Link to Article
Cogan  DG Opsoclonus, body tremulousness and benign encephalitis. Arch Ophthalmol 1968;79 (5) 545- 551
PubMed Link to Article
Baringer  JRSweeney  VPWinkler  GF An acute syndrome of ocular oscillations and truncal myoclonus. Brain 1968;91 (3) 473- 480
PubMed Link to Article
Hankey  GJSadka  M Ocular flutter, postural body tremulousness and CSF pleocytosis: a rare post-infectious syndrome. J Neurol Neurosurg Psychiatry 1987;50 (9) 1235- 1236
PubMed Link to Article
Ellenberger  CKeltner  JLStroud  MH Ocular dyskinesia in cerebellar disease. Brain 1972;95 (4) 685- 692
PubMed Link to Article
Wiest  GSafoschnik  GSchnaberth  GMueller  C Ocular flutter and truncal ataxia may be associated with enterovirus infection. J Neurol 1997;244 (5) 288- 292
PubMed Link to Article
Toupet  Mde Gramont  ABacri  DHaguenau  MPepin  B Flutter-opsoclonus: report on three cases. Rev Neurol (Paris) 1982;138 (3) 219- 239
PubMed
Kaminski  HJZee  DSLeigh  RJMendez  MF Ocular flutter and ataxia associated with AIDS-related complex. Neuroophthalmology 1991;11163- 167
Link to Article
Furman  JMEidelman  BHFromm  GH Spontaneous remission of paraneoplastic ocular flutter and saccadic intrusions. Neurology 1988;38 (3) 499- 501
PubMed Link to Article
Pieret  FSindic  CJChalon  MP  et al.  The anti-Hu syndrome: a clinical and immunological study of 7 cases. Acta Neurol Belg 1996;96 (2) 108- 116
PubMed
Odaka  MYuki  NHirata  K Anti-GQ1b IgG antibody syndrome: clinical and immunological range. J Neurol Neurosurg Psychiatry 2001;70 (1) 50- 55
PubMed Link to Article
Candeloro  EPiccolo  GBergamaschi  RRomani  ATavazzi  EVersino  M Acute oculomotor impairment with anti-GQ1b IgG due to central nervous system dysfunction. Funct Neurol 2005;20 (4) 173- 175
PubMed

Figures

Place holder to copy figure label and caption
Figure.

Oculographic recording showing bursts of rapid horizontal, conjugated, and sinusoidal movements without intersaccadic interval with eyes open and closed.

Graphic Jump Location

Tables

References

Gaymard  BPierrot  C Neurology of saccades and smooth pursuit. Curr Opin Neurol 1999;12 (1) 13- 19
PubMed Link to Article
Leigh  LJZee  DS The Neurology of Eye Movements. 3rd ed. New York, NY Oxford University Press1999;133- 144449- 456
Schon  FHodgson  TLMort  DKennard  C Ocular flutter associated with a localized lesion in the paramedian pontine reticular formation. Ann Neurol 2001;50 (3) 413- 416
PubMed Link to Article
Cogan  DG Opsoclonus, body tremulousness and benign encephalitis. Arch Ophthalmol 1968;79 (5) 545- 551
PubMed Link to Article
Baringer  JRSweeney  VPWinkler  GF An acute syndrome of ocular oscillations and truncal myoclonus. Brain 1968;91 (3) 473- 480
PubMed Link to Article
Hankey  GJSadka  M Ocular flutter, postural body tremulousness and CSF pleocytosis: a rare post-infectious syndrome. J Neurol Neurosurg Psychiatry 1987;50 (9) 1235- 1236
PubMed Link to Article
Ellenberger  CKeltner  JLStroud  MH Ocular dyskinesia in cerebellar disease. Brain 1972;95 (4) 685- 692
PubMed Link to Article
Wiest  GSafoschnik  GSchnaberth  GMueller  C Ocular flutter and truncal ataxia may be associated with enterovirus infection. J Neurol 1997;244 (5) 288- 292
PubMed Link to Article
Toupet  Mde Gramont  ABacri  DHaguenau  MPepin  B Flutter-opsoclonus: report on three cases. Rev Neurol (Paris) 1982;138 (3) 219- 239
PubMed
Kaminski  HJZee  DSLeigh  RJMendez  MF Ocular flutter and ataxia associated with AIDS-related complex. Neuroophthalmology 1991;11163- 167
Link to Article
Furman  JMEidelman  BHFromm  GH Spontaneous remission of paraneoplastic ocular flutter and saccadic intrusions. Neurology 1988;38 (3) 499- 501
PubMed Link to Article
Pieret  FSindic  CJChalon  MP  et al.  The anti-Hu syndrome: a clinical and immunological study of 7 cases. Acta Neurol Belg 1996;96 (2) 108- 116
PubMed
Odaka  MYuki  NHirata  K Anti-GQ1b IgG antibody syndrome: clinical and immunological range. J Neurol Neurosurg Psychiatry 2001;70 (1) 50- 55
PubMed Link to Article
Candeloro  EPiccolo  GBergamaschi  RRomani  ATavazzi  EVersino  M Acute oculomotor impairment with anti-GQ1b IgG due to central nervous system dysfunction. Funct Neurol 2005;20 (4) 173- 175
PubMed

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