0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editorial |

Measuring the Risk of Alzheimer Disease

Roger N. Rosenberg, MD, Editor
Arch Neurol. 2007;64(4):479-480. doi:10.1001/archneur.64.4.479.
Text Size: A A A
Published online

Extract

In recent years, there have been hundreds of published reports citing or refuting a genetic association of specific susceptibility genes and the occurrence of Alzheimer disease (AD).26 It is clear that mutations in the amyloid precursor protein (APP) gene (chromosome 21), presenilin 1 gene (chromosome 14), and presenilin 2 gene (chromosome 1) are causal of AD.7 It is also well established that the ε4 allele of apolipoprotein E is a major susceptibility factor for AD.2,4,5,7 However, a clear consensus of other potential susceptibility genes for AD remains to be reached. Progress in this regard has been achieved by Bertram et al,2 who have collected systematic analyses of AD genetic association studies in the AlzGene database, a publicly available, updated database that catalogs all genetic association studies related to AD. They have identified at least 12 potential AD susceptibility genes with statistically significant allelic summary odds ratios (ranging from 1.11-1.38 for risk alleles and 0.92-0.67 for protective alleles).2 They do express caution in citing these association analyses by stating that “our results must be interpreted with caution and considered preliminary until the putative disease-modifying effects have been confirmed in sufficiently powered analyses and until plausible molecular mechanisms are elucidated for the observed statistical associations.”2

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

16 Views
0 Citations
×

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
JAMAevidence.com

Care at the Close of Life: Evidence and Experience
Alzheimer Disease: "It's OK, Mama, If You Want to Go, It's OK"

The Rational Clinical Examination: Evidence-Based Clinical Diagnosis
Supplemental Content

brightcove.createExperiences();