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Original Contribution |

Measures of Adiposity and Dementia Risk in Elderly Persons FREE

José A. Luchsinger, MD; Bindu Patel, MPH; Ming-Xin Tang, PhD; Nicole Schupf, PhD; Richard Mayeux, MD
[+] Author Affiliations

Author Affiliations: Taub Institute for Research of Alzheimer's Disease and the Aging Brain (Drs Luchsinger, Tang, Schupf, and Mayeux and Ms Patel), Departments of Epidemiology (Drs Luchsinger, Schupf, and Mayeux) and Biostatistics (Dr Tang), Joseph P. Mailman School of Public Health, and Gertrude H. Sergievsky Center (Drs Schupf and Mayeux), Columbia University; and Division of General Medicine, Department of Medicine (Dr Luchsinger), and Departments of Neurology and Psychiatry (Dr Mayeux), Columbia University College of Physicians and Surgeons, New York, NY.


Arch Neurol. 2007;64(3):392-398. doi:10.1001/archneur.64.3.392.
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Published online

Background  Studies relating adiposity to dementia are conflicting. We explored the associations of body mass index (BMI), (calculated as weight in kilograms divided by the square of height in meters) waist circumference, and weight change to dementia, probable Alzheimer disease, and dementia associated with stroke (DAS).

Design  Persons without dementia were followed up for 5 years; 893 persons had BMI data, 907 had waist circumference data, and 709 had a second weight measurement. Dementia was ascertained using standard methods. Cox proportional hazards regression was used for analyses using follow-up as time to event, adjusting for demographics and apolipoprotein E-ε4 status.

Results  Compared with persons in the first quartile of BMI, persons in the third quartile had a lower dementia and Alzheimer disease risk and persons in the second quartile had a lower DAS risk. The association between BMI and dementia resembled a U shape in those younger than 76 years, while dementia risk decreased with higher BMI in those 76 years and older. The fourth quartile of waist circumference was related to a higher DAS risk in the whole sample, and to dementia and Alzheimer disease in persons younger than 76 years. Weight loss was related to a higher dementia and DAS risk, and weight gain was related to a higher DAS risk only.

Conclusions  The prospective association between adiposity and dementia differs depending on the anthropometric measure used, and is modified by age. This may explain previous conflicting reports.

Figures in this Article

Dementia prevalence may quadruple by 2047.1 High adiposity, hyperinsulinemia, and diabetes mellitus are increasing worldwide.25 High adiposity predicts hyperinsulinemia and diabetes mellitus,6 putative dementia risk factors.712 The few studies1315 exploring the association between adiposity, measured by body mass index (BMI), and dementia in elderly persons were conflicting. Reasons for this may include that waist circumference (WC) may be a better adiposity marker than BMI,16 that the association between high BMI and outcomes is attenuated with age,17 and that low BMI is a marker of weight loss, frailty, and preclinical dementia. We hypothesized that higher adiposity is related to higher dementia risk, and that this relation is attenuated by age. We examined the prospective associations of BMI, WC, and weight change to dementia in elderly persons, and explored their modification by age.

PARTICIPANTS AND SETTING

Participants were enrolled in a longitudinal study by random sampling of Medicare recipients 65 years or older residing in northern Manhattan (Washington Heights, Hamilton Heights, and Inwood), New York City.18 Each participant underwent an in-person interview of general health and function at study entry followed by a standard assessment, including medical history and physical, neurological, and neuropsychological examination.19 Baseline data were collected from 1992 through 1994. Follow-up data were collected at intervals of approximately 18 months. The institutional review board of Columbia-Presbyterian Medical Center, New York, approved this study.

Anthropometric measures were taken at first follow-up, when 1484 (69.8%) of 2126 persons were available; 1372 (92.5%) of those had anthropometric measures and 255 (17.2%) were excluded because of prevalent dementia. Among those persons with follow-up data after the first follow-up examination, 893 (60.2%) had information on BMI and 907 (61.1%) had information on WC; 709 persons (47.8%) had a second weight measurement at the subsequent examination with additional follow-up and were part of longitudinal analyses with weight change.

BMI, WC, AND WEIGHT CHANGE

The BMI was calculated as weight in kilograms divided by the square of height in meters. With the participant standing, body weight was measured to the nearest 0.1 kg with a balance scale, and height was measured without shoes to the nearest 0.5 cm. The WC represents excess fat in the abdomen out of proportion to total body fat, and is an independent predictor of vascular risk factors and morbidity.16 The WC was measured at the level of the iliac crest at minimal inspiration to the closest 0.1 cm. The BMI and WC were used as continuous variables and categorized by quartiles. We did not use National Heart, Lung, and Blood Institute criteria for BMI because its value in elderly persons is questionable.20 We calculated the yearly rate of weight change between the first and second follow-up interval and classified persons into 3 groups: (1) weight loss (>1 kg), (2) stable weight (1 kg of loss to 1 kg of gain), and (3) weight gain (>1 kg).

DIAGNOSIS OF DEMENTIA

A dementia diagnosis was made by consensus of neurologists, psychiatrists, and neuropsychologists. The dementia diagnosis was based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria,21 and required evidence of cognitive deficit and evidence of impairment in social or occupational function (Clinical Dementia Rating Scale score of ≥1).22 An Alzheimer disease (AD) diagnosis was based on the criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association.23 A diagnosis of probable AD was made when dementia could not be explained by other disorders. A diagnosis of possible AD was made when the most likely cause of dementia was AD, but there were other disorders that could contribute, such as stroke and Parkinson disease. A diagnosis of vascular dementia was made when it started within 3 months of the stroke and its local effects were thought to be the primary cause. Brain imaging was available in 85% of stroke cases; in the remainder, World Health Organization stroke criteria were used.24 We conducted analyses with 3 outcomes: all-cause dementia, probable AD, and dementia associated with stroke (DAS), which included vascular dementia and possible AD with stroke. The rationale for these outcomes is that obesity is related to vascular disease and stroke,25 and we sought to distinguish the association of adiposity to dementias with and without a vascular component.

COVARIATES

Diabetes mellitus, hypertension, heart disease, and smoking were defined by self-report. Heart disease included a history of atrial fibrillation, other arrhythmias, congestive heart failure, myocardial infarction, and angina pectoris. Smoking was subclassified into current and past smoking. Fasting plasma cholesterol and triglyceride levels were determined at first follow-up using standard enzymatic techniques. High-density lipoprotein cholesterol levels were determined after precipitation of apolipoprotein B–containing lipoproteins with phosphotungstic acid.26 The low-density lipoprotein cholesterol level was recalculated using the formula of Friedewald et al.27 The APOE (apolipoprotein E) genotypes were determined as described by Hixson and Vernier28 and Mayeux et al.29 We classified APOE-ε4 as present (homozygous or heterozygous) or absent.

STATISTICAL ANALYSES

Bivariate analyses compared variables among BMI quartiles. Continuous variables were compared using analysis of variance, and categorical variables were compared using χ2 tests.30 First, global tests for all quartiles were made. If significant differences were found, further comparisons were made for continuous variables using the Scheffé multiple comparisons procedure; for categorical variables, pairwise comparisons with the reference category were conducted. An α  value of .05 was used for all analyses. Proportional hazards models31 were used in multivariate analyses. The time-to-event variable was time from BMI or WC measurement to incident dementia; individuals who did not develop dementia were censored at last follow-up. For analyses with weight change, the time-to-event variable was time from the second weight measurement to dementia onset. Individuals who developed dementia other than the one of interest were censored at diagnosis. We show the results of multivariate analyses for 2 models: one adjusted for age and sex and one further adjusted for years of education, ethnic group, and APOE-ε4 status. We adjusted for diabetes mellitus, hypertension, low-density lipoprotein level, heart disease, stroke, and current smoking in secondary analyses. Because stroke defines DAS, it was not used as a covariate in analyses by dementia subtype. These variables, with the exception of smoking, may be caused by higher adiposity,32 may be in the pathway between adiposity and dementia, and were not included in the main models. We conducted 3 main analyses, relating the following: (1) BMI to dementia, (2) WC to dementia, and (3) weight change to dementia. The reference in analyses with BMI and WC was the first quartile; in analyses with weight change, it was the stable weight group.

Current smoking is associated with higher dementia risk33 and lower BMI,34 and we conducted secondary analyses excluding smokers. A lower BMI may be associated with unidentified premorbid conditions, including preclinical dementia,35 and we conducted secondary analyses excluding individuals with less than 18 months of follow-up. All analyses were conducted using SAS statistical software, version 9.1, for Windows (SAS Institute Inc, Cary, NC).

There were 181 incident dementia cases (3.9/100 person-years), 112 AD cases, and 53 DAS cases in 4536 person-years of follow-up (mean ± SD, 5.1 ± 2.6 years). The mean ± SD sample age was 77.0 ± 5.7 years. Of the sample, 69.9% were women; 31.8% were African American, 45.2% were Caribbean-Hispanic, and 22.9% were white (percentages do not total 100 because of rounding). The mean ± SD years of education were 8.8 ± 4.6, and 27.9% had APOE-ε4 present; 18.5% reported diabetes mellitus, 59.6% reported hypertension, 25.9% reported heart disease, and 11.5% reported stroke. The mean ± SD low-density lipoprotein level was 120.9 ± 34.9 mg/dL (3.13 ± 0.90 mmol/L).

We compared characteristics among quartiles of BMI (Table 1) using the first as the reference. Persons in the second quartile had a lower proportion of women, a higher diabetes mellitus prevalence, and lower prevalences of current smoking and stroke. Persons in the third quartile were younger, had higher hypertension and diabetes mellitus prevalences, and had a lower prevalence of current smoking. Persons in the fourth quartile were younger; had higher proportions of women and African Americans; had a lower proportion of whites; had higher hypertension, diabetes mellitus, and heart disease prevalences; and had a lower prevalence of current smoking.

Table Graphic Jump LocationTable 1. Table 1. Comparison of Relevant Characteristics Between BMI Quartiles*
RELATION OF BMI TO DEMENTIA

Body mass index as a continuous variable was not related to dementia (hazard ratio [HR], 0.9; 95% confidence interval [CI], 0.9-1.0), AD (HR, 0.9; 95% CI, 0.9-1.0), or DAS (HR, 1.1; 95% CI, 0.9-1.3) in fully adjusted models.

The third quartile (Table 2) was associated with lower dementia risk compared with the first quartile after adjusting for age, sex, years of education, ethnic group, and APOE-ε4 status. The association between the second quartile and lower dementia risk was close to statistical significance (P=.06). For AD, the third quartile was associated with lower risk. For DAS, the association between the second quartile and lower risk was almost statistically significant (P=.06). The inclusion of vascular risk factors in the models did not change the results.

Table Graphic Jump LocationTable 2. Table 2. Data Relating BMI Quartiles to Dementia Using the First Quartile as the Reference

In persons younger than 76 years, the association between BMI quartiles and dementia resembled a U shape (Figure 1). The second (HR, 0.4; 95% CI, 0.2-0.9) and third (HR, 0.3; 95% CI, 0.1-0.8) quartiles were related to lower risk, while the fourth (HR, 1.0; 95% CI, 0.4-2.1; P=.91 for trend) was similar to the reference. In older people (≥76 years), dementia risk decreased with increasing BMI; this association was almost statistically significant (fourth quartile HR, 0.6; 95% CI, 0.4-1.1; P=.07 for trend). These associations were not modified by sex and did not change after exclusion of current smokers or persons with a short follow-up.

Place holder to copy figure label and caption
Figure 1.

Hazard ratios relating quartiles of body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) to all-cause dementia in persons younger than 76 years and in persons 76 years and older, adjusting for age, sex, years of education, ethnic group, and apolipoprotein E-ε4 status. Only the hazard ratios for the second (P=.05) and third (P=.01) quartiles in persons younger than 76 years were statistically significant.

Graphic Jump Location
RELATION OF WC TO DEMENTIA

The WC as a continuous variable was not associated with dementia (HR, 1.0; 95% CI, 0.9-1.0); the associations with AD and DAS were similar. The WC quartiles were not related to dementia or AD (Table 3), but DAS risk was increased for the fourth quartile (P=.02 for trend) after adjusting for age, sex, years of education, ethnic group, and APOE-ε4 status. The results were virtually unchanged after adjusting for vascular risk factors. In younger elderly persons, the fourth quartile was related to higher dementia (HR, 2.3; 95% CI, 0.9-5.8; P=.03 for trend) and AD (HR, 5.1; 95% CI, 1.0-26.4; P=.04 for trend) risk, but, in older persons, the fourth quartile was not related to dementia (HR, 1.0; 95% CI, 0.6-1.7; P=.93 for trend) or AD (HR, 0.8; 95% CI, 0.4-1.8; P=.37 for trend) (Figure 2).

Place holder to copy figure label and caption
Figure 2.

Hazard ratios relating quartiles of waist circumference (WC) to all-cause dementia in persons younger than 76 years and in persons 76 years and older, adjusting for age, sex, years of education, ethnic group, and apolipoprotein E-ε4 status. The hazard ratio for the fourth quartile of WC was close to statistical significance (P=.06) and the P value for trend (P=.03) in persons younger than 76 years was statistically significant.

Graphic Jump Location
Table Graphic Jump LocationTable 3. Table 3. Data Relating WC Quartiles to Dementia Using the First Quartile as the Reference
RELATION OF WEIGHT CHANGE TO DEMENTIA

We had 1 follow-up weight measurement in 709 persons, of 713 persons without dementia eligible for follow-up. The mean ± SD interval between weight measurements was 1.3 ± 0.6 years. The mean ± SD weight change was −0.5 ± 3.4 kg. The mean ± SD follow-up after the second weight measurement was 4.7 ± 2.1 years. Weight change as a continuous variable was associated with decreased dementia risk (HR, 0.9; 95% CI, 0.8-0.9). In analyses categorizing with changes as loss, stable, or gain, persons with weight loss had a higher dementia risk (Table 4) compared with persons with a stable weight after adjustment for baseline BMI, age, sex, years of education, ethnic group, and APOE-ε4 status. This association was strongest for DAS. The DAS risk was also higher in persons who gained weight. The results were unchanged in models with vascular risk factors and after excluding current smokers and persons with a short follow-up. There was no effect modification by age or sex.

Table Graphic Jump LocationTable 4. Table 4. Data Relating Weight Loss and Weight Gain to Dementia Using Stable Weight as the Reference*

We conducted additional analyses exploring different cutoffs for weight change (tertiles, 25th and 75th percentiles, and 10th and 90th percentiles), and the results were similar.

The association between adiposity and incident dementia varied with the measure used and the outcome considered, and was modified by age. The only association that clearly resembled a linear pattern (higher risk with higher quartile) was that of WC and DAS. However, the fourth WC quartile was related to a higher dementia and AD risk in persons younger than 76 years, but not in the oldest old (those ≥76 years). The association of BMI with dementia resembled a U shape in those younger than 76 years. Weight loss was associated with a higher dementia risk. This association was stronger for DAS, and weight gain was also associated with DAS.

Alzheimer disease and vascular dementia are the most common forms of dementia.36 Alzheimer disease is probably caused by brain deposition of amyloid β,37 and peripheral hyperinsulinemia may have an important role in its clearance.38 Vascular risk factors and stroke cause vascular dementia,3942 but they may also cause AD.43,44 There are conflicting data relating hyperinsulinemia,7,8,4547 diabetes mellitus,4851 and hyperinsulinemia features, such as hyperlipidemia52 and hypertension,5256 to a higher risk of cognitive decline and AD. Higher adiposity is related to hyperinsulinemia, diabetes mellitus, hypertension, dyslipidemia, heart disease, and stroke.32,57 Thus, we hypothesized that a high BMI and WC are associated with a higher dementia, AD, and DAS risk.

A high BMI in middle age is associated with a higher dementia risk.58,59 A higher BMI at the ages of 70, 75, and 79 years also predicts a higher dementia risk.15 However, there have been reports of no association14 and of a lower BMI related to a higher AD risk.13 These paradoxical findings could be explained by different age groups in different studies; those conducted in middle age show a relation of high BMI to increased dementia risk, while those in older populations are conflicting. The association of high BMI with cardiovascular and general mortality is attenuated in older age groups, and high BMI becomes a predictor of decreased mortality in the oldest old.17 This is possibly because of survival bias and decreased value of BMI as an adiposity measure in the oldest old. Aging is characterized by lean body mass loss and adipose tissue increase without weight gain, which may not be captured by BMI, and traditional adiposity measures are less useful in elderly persons.60 Another potential explanation for paradoxical findings is the possibility of a U-shaped association between BMI and dementia, as has been reported for other outcomes.34 Low BMI related to worse outcomes is usually ascribed to conditions associated with weight loss. Higher BMI related to worse outcomes is usually interpreted as evidence of the consequences of high adiposity. The results of our study suggest a U-shaped association between BMI and dementia in younger elderly persons, while a higher BMI is related to lower dementia risk in the oldest old. It is possible that persons with the lowest BMI lost weight because of premorbid dementia. It is also possible that a low BMI is the consequence of hyperinsulinemia, which precedes weight loss61 and is related to higher dementia risk.7,8

Waist circumference has been proposed as a better adiposity measure in elderly persons than BMI.16,60,62 We found that a higher WC was associated with a higher DAS risk for all age groups. The association between vascular risk factors and dementia is clearly stronger for DAS compared with AD,43 and this may explain why WC only predicted DAS in the whole sample. However, a higher WC was associated with a higher dementia and AD risk in younger elderly persons, consistent with the notion that adiposity measures lose their predictive ability in the oldest old.60

Persons may lose weight before dementia diagnosis,14,63 and this has been interpreted as a consequence rather than a direct cause of the disease.14 We did not have enough data to assess weight change up to dementia diagnosis. We had weights at 2 time points for a subsample and explored how weight change predicted dementia prospectively. We found that weight loss predicted higher dementia risk, in agreement with previous work. As mentioned previously, this could be a consequence of the dementia process, but could also be the consequence and a marker of hyperinsulinemia,63 an emerging dementia risk factor.7,8 We also found that weight gain predicted higher DAS risk, which, to our knowledge, has not been previously reported. This could reflect an increase in vascular risk factors with weight gain,32 but could also be a consequence of cardiovascular disease, such as heart failure causing edema and weight gain.64

We must consider the possibility that confounding, chance, or bias explains the results of this study. We conducted analyses excluding current smokers and persons with short follow-up, and the results were essentially unchanged. We adjusted for years of education and ethnic group as indexes of socioeconomic background without change in our findings, but we cannot rule out residual confounding. The ascertainment of covariates, such as smoking, was made by self-report, likely resulting in some misclassification that could have resulted in residual confounding. Another consideration is the fact that we conducted multiple comparisons, including those in stratified analyses. Invocation of multiple comparisons as an explanation of results is a controversial issue,65 but it is possible that our results could be explained by chance. The most striking results occurred in the stratified analyses. The finding of significant results for some quartiles by chance could lead to the identification of patterns that also occurred by chance. Despite the results not being unexpected, and consistent with previous publications in the aging literature, chance due to multiple comparisons is a possibility as an explanation for our findings, and our analyses should be replicated in other samples. The number of persons developing DAS was appreciably smaller than those developing AD, and this could have resulted in chance findings because of sparse data. When interpreting and generalizing the results, it is important to take into account that this study occurred in the context of a cohort study of elderly persons, with multiple ethnic groups, in an urban setting, with a high prevalence of vascular risk factors. It is a cohort with potential selection biases, particularly because high adiposity is related to increased morbidity and mortality that could have limited participation to persons who were less likely to have this risk factor.

Our study has several strengths. We had comprehensive research procedures for the diagnosis of dementia. We also had measures of BMI and WC, and weight at 2 time points, but did not have a weight history before inclusion in the cohort. To the best of our knowledge, this is the first study examining the relationship between WC and dementia in elderly persons.

Our results show that high adiposity may be associated with higher dementia risk, particularly in younger elderly persons. However, this association could be confounded by low weight and weight loss due to preclinical disease, and is attenuated in older age groups. This may explain conflicts in previous studies. Our results need to be replicated in other studies. Similar studies are needed with imaging or biomarkers of adipose tissue.

Correspondence: José A. Luchsinger, MD, Division of General Medicine, Columbia University, 630 W 168th St, PH9E-105, New York, NY 10032 (jal94@columbia.edu).

Accepted for Publication: April 25, 2006.

Author Contributions:

Study concept and design: Luchsinger and Mayeux. Acquisition of data: Schupf and Mayeux. Analysis and interpretation of data: Luchsinger, Patel, Tang, Schupf, and Mayeux. Drafting of the manuscript: Luchsinger, Patel, Tang, and Mayeux. Critical revision of the manuscript for important intellectual content: Schupf. Statistical analysis: Patel, Tang, and Schupf. Obtained funding: Luchsinger and Mayeux. Administrative, technical, and material support: Mayeux. Study supervision: Mayeux.

Financial Disclosure: None reported.

Funding/Support: This study was supported by grants AG07232, AG07702, 1K08AG20856-01, and RR00645 from the National Institutes of Health; the Charles S. Robertson Memorial Gift for Research on Alzheimer's Disease; the Blanchette Hooker Rockefeller Foundation; and the New York City Council Speaker's Fund for Public Health Research.

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PubMed
Carantoni  MZuliani  GMunari  MRD’Elia  KPalmieri  EFellin  R Alzheimer disease and vascular dementia: relationships with fasting glucose and insulin levels. Dement Geriatr Cogn Disord 2000;11176- 180
PubMed
Ott  AStolk  RPHofman  Avan Harskamp  FGrobbee  DEBreteler  MM Association of diabetes mellitus and dementia: the Rotterdam Study. Diabetologia 1996;391392- 1397
PubMed
Gregg  EWBeckles  GLWilliamson  DF  et al.  Diabetes and physical disability among older US adults. Diabetes Care 2000;231272- 1277
PubMed
Vanhanen  MKuusisto  JKoivisto  K  et al.  Type-2 diabetes and cognitive function in a non-demented population. Acta Neurol Scand 1999;10097- 101
PubMed
Janson  JLaedtke  TParisi  JEO’Brien  PPetersen  RCButler  PC Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 2004;53474- 481
PubMed
Kivipelto  MLaakso  MPTuomilehto  JNissinen  ASoininen  H Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: potential for pharmacological intervention. CNS Drugs 2002;16435- 444
PubMed
Kivipelto  MHelkala  ELHanninen  T  et al.  Midlife vascular risk factors and late-life mild cognitive impairment: a population-based study. Neurology 2001;561683- 1689
PubMed
Posner  HBTang  MXLuchsinger  JLantigua  RStern  YMayeux  R The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function. Neurology 2002;581175- 1181
PubMed
Skoog  IGustafson  D Hypertension, hypertension-clustering factors and Alzheimer's disease. Neurol Res 2003;25675- 680
PubMed
Skoog  ILernfelt  BLandahl  S  et al.  15-Year longitudinal study of blood pressure and dementia. Lancet 1996;3471141- 1145
PubMed
Reaven  G Insulin resistance, type 2 diabetes mellitus, and cardiovascular disease: the end of the beginning. Circulation 2005;1123030- 3032
PubMed
Whitmer  RAGunderson  EPBarrett-Connor  EQuesenberry  CP  JrYaffe  K Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study [published online ahead of print April 29, 2005]. BMJ20053301360doi:10.1136/bmj.38446.466238.E0
Kivipelto  MNgandu  TFratiglioni  L  et al.  Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol 2005;621556- 1560
PubMed
Stevens  JCai  JJuhaeri  Thun  MJWilliamson  DFWood  JL Consequences of the use of different measures of effect to determine the impact of age on the association between obesity and mortality. Am J Epidemiol 1999;150399- 407
PubMed
Wedick  NMMayer-Davis  EJWingard  DLAddy  CLBarrett-Connor  E Insulin resistance precedes weight loss in adults without diabetes: the Rancho Bernardo Study. Am J Epidemiol 2001;1531199- 1205
PubMed
Visscher  TLSeidell  JCMolarius  Avan der Kuip  DHofman  AWitteman  JC A comparison of body mass index, waist-hip ratio and waist circumference as predictors of all-cause mortality among the elderly: the Rotterdam study. Int J Obes Relat Metab Disord 2001;251730- 1735
Buchman  ASWilson  RSBienias  JLShah  RCEvans  DABennett  DA Change in body mass index and risk of incident Alzheimer disease. Neurology 2005;65892- 897
PubMed
Schiff  GDFung  SSperoff  TMcNutt  RA Decompensated heart failure: symptoms, patterns of onset, and contributing factors. Am J Med 2003;114625- 630
PubMed
Rothman  KJ No adjustments are needed for multiple comparisons. Epidemiology 1990;143- 46
PubMed

Figures

Place holder to copy figure label and caption
Figure 1.

Hazard ratios relating quartiles of body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters) to all-cause dementia in persons younger than 76 years and in persons 76 years and older, adjusting for age, sex, years of education, ethnic group, and apolipoprotein E-ε4 status. Only the hazard ratios for the second (P=.05) and third (P=.01) quartiles in persons younger than 76 years were statistically significant.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Hazard ratios relating quartiles of waist circumference (WC) to all-cause dementia in persons younger than 76 years and in persons 76 years and older, adjusting for age, sex, years of education, ethnic group, and apolipoprotein E-ε4 status. The hazard ratio for the fourth quartile of WC was close to statistical significance (P=.06) and the P value for trend (P=.03) in persons younger than 76 years was statistically significant.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 1. Table 1. Comparison of Relevant Characteristics Between BMI Quartiles*
Table Graphic Jump LocationTable 2. Table 2. Data Relating BMI Quartiles to Dementia Using the First Quartile as the Reference
Table Graphic Jump LocationTable 3. Table 3. Data Relating WC Quartiles to Dementia Using the First Quartile as the Reference
Table Graphic Jump LocationTable 4. Table 4. Data Relating Weight Loss and Weight Gain to Dementia Using Stable Weight as the Reference*

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Kalmijn  SFoley  DWhite  L  et al.  Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men: the Honolulu-Asia aging study. Arterioscler Thromb Vasc Biol 2000;202255- 2260
PubMed
Carantoni  MZuliani  GMunari  MRD’Elia  KPalmieri  EFellin  R Alzheimer disease and vascular dementia: relationships with fasting glucose and insulin levels. Dement Geriatr Cogn Disord 2000;11176- 180
PubMed
Ott  AStolk  RPHofman  Avan Harskamp  FGrobbee  DEBreteler  MM Association of diabetes mellitus and dementia: the Rotterdam Study. Diabetologia 1996;391392- 1397
PubMed
Gregg  EWBeckles  GLWilliamson  DF  et al.  Diabetes and physical disability among older US adults. Diabetes Care 2000;231272- 1277
PubMed
Vanhanen  MKuusisto  JKoivisto  K  et al.  Type-2 diabetes and cognitive function in a non-demented population. Acta Neurol Scand 1999;10097- 101
PubMed
Janson  JLaedtke  TParisi  JEO’Brien  PPetersen  RCButler  PC Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 2004;53474- 481
PubMed
Kivipelto  MLaakso  MPTuomilehto  JNissinen  ASoininen  H Hypertension and hypercholesterolaemia as risk factors for Alzheimer's disease: potential for pharmacological intervention. CNS Drugs 2002;16435- 444
PubMed
Kivipelto  MHelkala  ELHanninen  T  et al.  Midlife vascular risk factors and late-life mild cognitive impairment: a population-based study. Neurology 2001;561683- 1689
PubMed
Posner  HBTang  MXLuchsinger  JLantigua  RStern  YMayeux  R The relationship of hypertension in the elderly to AD, vascular dementia, and cognitive function. Neurology 2002;581175- 1181
PubMed
Skoog  IGustafson  D Hypertension, hypertension-clustering factors and Alzheimer's disease. Neurol Res 2003;25675- 680
PubMed
Skoog  ILernfelt  BLandahl  S  et al.  15-Year longitudinal study of blood pressure and dementia. Lancet 1996;3471141- 1145
PubMed
Reaven  G Insulin resistance, type 2 diabetes mellitus, and cardiovascular disease: the end of the beginning. Circulation 2005;1123030- 3032
PubMed
Whitmer  RAGunderson  EPBarrett-Connor  EQuesenberry  CP  JrYaffe  K Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study [published online ahead of print April 29, 2005]. BMJ20053301360doi:10.1136/bmj.38446.466238.E0
Kivipelto  MNgandu  TFratiglioni  L  et al.  Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch Neurol 2005;621556- 1560
PubMed
Stevens  JCai  JJuhaeri  Thun  MJWilliamson  DFWood  JL Consequences of the use of different measures of effect to determine the impact of age on the association between obesity and mortality. Am J Epidemiol 1999;150399- 407
PubMed
Wedick  NMMayer-Davis  EJWingard  DLAddy  CLBarrett-Connor  E Insulin resistance precedes weight loss in adults without diabetes: the Rancho Bernardo Study. Am J Epidemiol 2001;1531199- 1205
PubMed
Visscher  TLSeidell  JCMolarius  Avan der Kuip  DHofman  AWitteman  JC A comparison of body mass index, waist-hip ratio and waist circumference as predictors of all-cause mortality among the elderly: the Rotterdam study. Int J Obes Relat Metab Disord 2001;251730- 1735
Buchman  ASWilson  RSBienias  JLShah  RCEvans  DABennett  DA Change in body mass index and risk of incident Alzheimer disease. Neurology 2005;65892- 897
PubMed
Schiff  GDFung  SSperoff  TMcNutt  RA Decompensated heart failure: symptoms, patterns of onset, and contributing factors. Am J Med 2003;114625- 630
PubMed
Rothman  KJ No adjustments are needed for multiple comparisons. Epidemiology 1990;143- 46
PubMed

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