Autism is a neurologic disorder characterized by impaired communication and social interaction. Results of previous studies showed biochemical evidence for abnormal platelet reactivity and altered blood flow in children with autism.
To evaluate the vascular phenotype in children with autism.
Design and Main Outcome Measures
Urinary levels of isoprostane F2α-VI, a marker of lipid peroxidation; 2,3-dinor-thromboxane B2, which reflects platelet activation; and 6-keto-prostaglandin F1α, a marker of endothelium activation, were measured by means of gas chromatography-mass spectrometry in subjects with autism and healthy control subjects.
Setting and Subjects
Children with a clinical diagnosis of autism attending the Pfeiffer Treatment Center.
Compared with controls, children with autism had significantly higher urinary levels of isoprostane F2α-VI, 2,3-dinor-thromboxane B2, and 6-keto-prostaglandin F1α. Lipid peroxidation levels directly correlated with both vascular biomarker ratios.
Besides enhanced oxidative stress, platelet and vascular endothelium activation also could contribute to the development and clinical manifestations of autism.