0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Observation |

Deep Brain Stimulation of the Internal Segment of the Globus Pallidus in Delayed Runaway Dyskinesia FREE

John Graff-Radford, BS; Kelly D. Foote, MD; Ramon L. Rodriguez, MD; Hubert H. Fernandez, MD; Robert A. Hauser, MD; Atchar Sudhyadhom, MS; Christian A. Rosado, BS; Justin C. Sanchez, PhD; Michael S. Okun, MD
[+] Author Affiliations

Author Affiliations: Departments of Neurology, University of Florida Movement Disorders Center (Messrs Graff-Radford and Rosado and Drs Rodriguez, Fernandez, and Okun), Neurosurgery, McKnight Brain Institute (Drs Foote and Okun and Mr Sudhyadhom), and Pediatrics (Dr Sanchez), University of Florida, Gainesville; and Department of Neurology, University of South Florida, Tampa (Dr Hauser).


Arch Neurol. 2006;63(8):1181-1184. doi:10.1001/archneur.63.8.1181.
Text Size: A A A
Published online

ABSTRACT

Background  Dyskinesias that occur during a period without medication after embryonic cell transplantation have been commonly reported in double-blind trials; however, to date, they have not been reported in the few patients who participated in open-label pilot studies.

Design  Single case observation with preoperative and postoperative data, and intraoperative single-cell physiology.

Patient  A patient who underwent embryonic cell transplantation in 1993 as part of the University of South Florida open-label study was referred for evaluation of intractable dyskinesia of the right arm. The dyskinesia was present during evaluation of the patient after a 12-hour period without medication and was clinically disabling. It was manifested as a severe groping movement of the hand. Intraoperative physiologic evaluation revealed decreased firing rates in the internal segment of the globus pallidus.

Results  Deep brain stimulation of the internal segment of the globus pallidus resulted in resolution of the dyskinesia.

Conclusion  This case highlights the delayed development of runaway dyskinesia after a period without medication as an important potential long-term adverse effect of embryonic cell transplantation in patients with Parkinson disease.

Figures in this Article

Runaway dyskinesia has been reported as a complication of embryonic striatal transplantation of dopaminergic cells in medication-refractory Parkinson disease (PD).14 The mechanism of runaway dyskinesia remains unknown, although it has been speculated that factors that may influence its development may include partial graft survival; graft growth, graft location, and the number of grafts; graft cell types; and method used in performing graft transplantation.14 Although the few patients in the open-label pilot study did not exhibit runaway dyskinesia at the initial follow-up, we report the case of a patient with delayed dyskinesia that developed after a period without medication (also known as “off medication”) who responded favorably to deep brain stimulation (DBS).

METHODS

This is a single case report of a patient followed up 10 years after embryonic cell transplantation was performed to treat PD. Before surgery, the patient's condition was evaluated off medications and when he was receiving medication (also known as “on medications”). After surgery, he was evaluated during periods with medication–with stimulation, without medication–with stimulation, with medication–without stimulation, and without medication–without stimulation.

REPORT OF A CASE

A 50-year-old man with a 15-year history of PD received bilateral embryonic transplants into the postcommissural putamen region (patient 4 in the University of South Florida transplantation pilot study5). He reported that his symptoms improved for 1 to 2 years after the transplantation, but then progressively worsened. Approximately 11 years after the transplantation procedure, the patient was seen for surgical evaluation because of intractable dyskinesia of the right arm. In addition to the severe right-sided dyskinesia, he had tremor, asymmetric rigidity, festinating gait, frequent falling, and postural instability. The dyskinesia, which had developed during the preceding 3 years, was characterized by a groping movement of the right hand and was worse with medication. The friction from the movement resulted in large holes in the patient's right upper pants leg (Figure 1). The movement worsened progressively.

Place holder to copy figure label and caption
Figure 1.

Typical hole in the pants leg caused by groping hand movement in a patient with runaway off-medication dyskinesia. A white background was used behind the hole for contrast. This photograph has the main hole at 1 and 3 times magnification.

Graphic Jump Location

The dyskinesia was present when the patient's condition was evaluated during a 12-hour period without medication. “On-off medication” Unified Parkinson’s Disease Rating Scale (UPDRS) testing demonstrated a significant levodopa response (42%; UPDRS score, 59 without medication and 34 with medication). Deep brain stimulation of the internal segment of the left globus pallidus (GPi) resulted in resolution of the dyskinesia and improvement in motor symptoms. Five GPi neurons measured during DBS surgery while the patient was without medication and dyskinetic had a mean firing rate (spikes per second) of 73.4. Table 1 lists the cells recorded during surgery, and Figure 2 shows a microelectrode recording obtained during surgery. The patient has been followed up for 6 months since DBS, with major clinical evaluations at baseline and at 142 and 198 days after surgery. At 142 days after surgery, the patient showed an improvement in UPDRS testing from baseline (49% improvement, UPDRS score of 30 without medication–with DBS; and 54% improvement, UPDRS score of 27 with medication–with DBS). At 198 days, the UPDRS score without medication–without DBS (for 12 hours) was 44, and with medication–without DBS was 33, which was a 44% improvement from baseline (Table 2).

Table Graphic Jump LocationTable 1. Intraoperative Firing Statistics for Cells Encountered in the Surgical Procedure
Place holder to copy figure label and caption
Figure 2.

Cells from the intra-operative microelectrode recording cells are labeled according to their occurrence in Table 1. Blue indicates striatum; green, external segment of the globus pallidum; red, internal segment of the globus pallidum; yellow, optic tract; and black, anterior commissure. Five microelectrode recording (MER) passes were performed; a sample of 3 of the passes is shown on an approximate 21.5-mm sagittal atlas plane. The squares in the internal segment of the globus pallidum indicate the presence of sensorimotor cells. On the x-axis, the positive numbers indicate the anterior direction; on the y-axis, the superior direction. B indicates locations in which border cells were identified during MER; F, locations in which fiber cells were identified during MER; and Q, locations that were found to be quiet during MER.

Graphic Jump Location

COMMENT

Embryonic nigral transplantation in our patient resulted in delayed runaway dyskinesia. The runaway dyskinesia developed approximately 11 years after the transplantation procedure, when the patient was not receiving any medication, and was effectively treated with GPi DBS. This long delay to development of off-medication dyskinesia is in some contrast to the findings in the double-blind studies in which runaway dyskinesia occurred 6 to 24 months after transplantation.1,2 The findings in this case underscore the need for longer follow-up studies in research subjects with PD with grafts placed in the putamen. This case also illustrates that runaway dyskinesia may effectively be treated with GPi DBS, although the best approach will require further study.

Selected patients with PD have received fetal nigral implants since about 1987. These trials have demonstrated that transplanted cells can survive and even grow in the human brain.4 The promising results of small open-label studies spurred 2 prospective double-blind surgical trials.1,2 The results of these trials, however, did not reproduce the success observed in open-label studies. Both the Denver-Columbia group and the Mount Sinai–University of South Florida group reported off-medication dyskinesia, later referred to as runaway dyskinesia. This adverse effect was observed in 15% of patients in the Denver-Columbia trial1 and 56% of patients in the Mount Sinai–University of South Florida trial.2

While many groups have suggested possible mechanisms for runaway dyskinesia, the exact cause or causes remain unknown. Typically, dyskinesia is a complication of levodopa therapy6,7 but has also been seen with DBS.8,9 This hyperkinetic adverse effect has been hypothesized to result from pulsatile stimulation of dopamine receptors. This pulsatile stimulation may result in changes, mainly in firing pattern, of the basal ganglia structures.6 Although the mechanism for this new phenomenon, runaway dyskinesia, is unknown, several groups have proposed theories that may lead to its genesis. Freed et al1 have hypothesized that continued growth of the transplant may lead to an overflow of dopamine, resulting in dyskinesia even in the off-medication state. The delay in onset may at least be partially explained by this hypothesis. Olanow et al2 have proposed a different explanation. They hypothesize that off-medication dyskinesia in transplant recipients may mimic diphasic dyskinesia, seen at the beginning and end of levodopa dose administration. In diphasic dyskinesia, low striatal dopamine concentrations are thought to be responsible for dyskinesia. Our patient demonstrated his worst UPDRS score (59) when dyskinetic and in the off-medication state. Typically, dyskinesia is associated with the best motor scores while taking medication. It could be argued that this patient had what would be diphasic dyskinesia, in which prominent dyskinesia was present but the patient was not completely in the on-medication state. Olanow et al2 further suggest that immune rejection and partial reinnervation of the graft could also contribute to the imbalance leading to runaway dyskinesia.

The mean firing rate of the 5 GPi neurons reported in this paper reflect a normal GPi frequency of firing in PD. Papa et al10 demonstrated that GPi firing rates decrease when a primate enters the on-medication state and again decrease when dyskinesia develops. In our patient, the normal GPi firing rates suggest a separate mechanism from levodopa-induced dyskinesia, as studied by Papa et al, perhaps some sort of innervation from the graft itself. The firing rates of the neurons and striatum of the external segment of the globus pallidum are also consistent with these data. To our knowledge, the GPi firing rate during diphasic dyskinesia has not been published, although, in theory, a decrease in rate may be expected. The groping motion in this patient could suggest involvement of the frontal striatal circuitry and possibly of the supplementary motor area and cingulate cortex,11,12 and could also be a potential reason for the physiologic findings. This hypothesis cannot be substantiated by data provided from this single case. The findings in future subjects with off-medication dyskinesia should be studied, along with intraoperative physiology and functional imaging, in an effort to improve our understanding of potential mechanisms for such dyskinesia.

This article stresses the need for longer follow-up of patients receiving transplant therapy for the treatment of PD. Complications of surgical therapy for PD, such as those previously seen with gamma knife or radiation treatment13 and those after graft-induced runaway dyskinesia, underscore the importance of monitoring for both delayed benefits and delayed complications of therapy. Although this is only one case report, much can be potentially learned from the manifestations and treatment of delayed runaway dyskinesia.

ARTICLE INFORMATION

Correspondence: Michael S. Okun, MD, Department of Neurology, University of Florida Movement Disorders Center, PO Box 100236, Gainesville, FL (okun@neurology.ufl.edu).

Accepted for Publication: October 23, 2005.

Author Contributions:Study concept and design: Graff-Radford, Foote, Fernandez, and Okun. Acquisition of data: Graff-Radford, Foote, Rodriguez, Hauser, Rosado, Sanchez, and Okun. Analysis and interpretation of data: Graff-Radford, Foote, Hauser, Sudhyadhom, Sanchez, and Okun. Drafting of the manuscript: Graff-Radford, Rodriguez, Fernandez, Sudhyadhom, Rosado, Sanchez, and Okun. Critical revision of the manuscript for important intellectual content: Graff-Radford, Foote, Hauser, Rosado, Sanchez, and Okun. Statistical analysis: Graff-Radford, Sanchez. Administrative, technical, and material support: Foote, Sudhyadhom, Rosado, and Okun. Study supervision: Foote, Rodriguez, Fernandez, Sanchez, and Okun.

REFERENCES

Freed  CRGreene  PEBreeze  RE  et al.  Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 2001;344710- 719
PubMed Link to Article
Olanow  CWGoetz  CGKordower  JH  et al.  A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 2003;54403- 414
PubMed Link to Article
Winkler  CKirik  DBjorklund  A Cell transplantation in Parkinson's disease: how can we make it work? Trends Neurosci 2005;2886- 92
PubMed Link to Article
Hagell  PPiccini  PBjorkland  A  et al.  Dyskinesias following neural transplantation in Parkinson's disease. Nat Neurosci 2002;5627- 628
PubMed
Hauser  RAFreeman  TBSnow  BJ  et al.  Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease. Arch Neurol 1999;56179- 187
PubMed Link to Article
Olanow  CWAgid  YMizuno  Y  et al Levodopa in the treatment of Parkinson's disease: current controversies. Mov Disord2004199971005[published correction appears in Mov Disord. 2005;20:645]
PubMed
Obeso  JARodriguez-Oroz  MCRodriguez  MDeLong  MROlanow  CW Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model. Ann Neurol 2000;47(suppl 1)S22- S34
Volkmann  JHerzog  JKopper  FDeuschl  G Introduction to the programming of deep brain stimulators. Mov Disord 2002;17(suppl 3)S181- S187
PubMed Link to Article
Volkmann  J Deep brain stimulation for the treatment of Parkinson's disease. J Clin Neurophysiol 2004;216- 17
PubMed Link to Article
Papa  SMDesimone  RFiorani  MOldfield  EH Internal globus pallidus discharge is nearly suppressed during levodopa-induced dyskinesias. Ann Neurol 1999;46732- 738
PubMed Link to Article
Archibald  SJMateer  CAKerns  KA Utilization behavior: clinical manifestations and neurological mechanisms. Neuropsychol Rev 2001;11117- 130. Review
PubMed Link to Article
Hashimoto  RTanaka  Y Contribution of the supplementary motor area and anterior cingulate gyrus to pathological grasping phenomena. Eur Neurol 1998;40151- 158
Link to Article
Okun  MSStover  NPSubramanian  T  et al.  Complications of gamma knife surgery for Parkinson disease. Arch Neurol 2001;581995- 2002
PubMed Link to Article

Figures

Place holder to copy figure label and caption
Figure 1.

Typical hole in the pants leg caused by groping hand movement in a patient with runaway off-medication dyskinesia. A white background was used behind the hole for contrast. This photograph has the main hole at 1 and 3 times magnification.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Cells from the intra-operative microelectrode recording cells are labeled according to their occurrence in Table 1. Blue indicates striatum; green, external segment of the globus pallidum; red, internal segment of the globus pallidum; yellow, optic tract; and black, anterior commissure. Five microelectrode recording (MER) passes were performed; a sample of 3 of the passes is shown on an approximate 21.5-mm sagittal atlas plane. The squares in the internal segment of the globus pallidum indicate the presence of sensorimotor cells. On the x-axis, the positive numbers indicate the anterior direction; on the y-axis, the superior direction. B indicates locations in which border cells were identified during MER; F, locations in which fiber cells were identified during MER; and Q, locations that were found to be quiet during MER.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 1. Intraoperative Firing Statistics for Cells Encountered in the Surgical Procedure

References

Freed  CRGreene  PEBreeze  RE  et al.  Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 2001;344710- 719
PubMed Link to Article
Olanow  CWGoetz  CGKordower  JH  et al.  A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 2003;54403- 414
PubMed Link to Article
Winkler  CKirik  DBjorklund  A Cell transplantation in Parkinson's disease: how can we make it work? Trends Neurosci 2005;2886- 92
PubMed Link to Article
Hagell  PPiccini  PBjorkland  A  et al.  Dyskinesias following neural transplantation in Parkinson's disease. Nat Neurosci 2002;5627- 628
PubMed
Hauser  RAFreeman  TBSnow  BJ  et al.  Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease. Arch Neurol 1999;56179- 187
PubMed Link to Article
Olanow  CWAgid  YMizuno  Y  et al Levodopa in the treatment of Parkinson's disease: current controversies. Mov Disord2004199971005[published correction appears in Mov Disord. 2005;20:645]
PubMed
Obeso  JARodriguez-Oroz  MCRodriguez  MDeLong  MROlanow  CW Pathophysiology of levodopa-induced dyskinesias in Parkinson's disease: problems with the current model. Ann Neurol 2000;47(suppl 1)S22- S34
Volkmann  JHerzog  JKopper  FDeuschl  G Introduction to the programming of deep brain stimulators. Mov Disord 2002;17(suppl 3)S181- S187
PubMed Link to Article
Volkmann  J Deep brain stimulation for the treatment of Parkinson's disease. J Clin Neurophysiol 2004;216- 17
PubMed Link to Article
Papa  SMDesimone  RFiorani  MOldfield  EH Internal globus pallidus discharge is nearly suppressed during levodopa-induced dyskinesias. Ann Neurol 1999;46732- 738
PubMed Link to Article
Archibald  SJMateer  CAKerns  KA Utilization behavior: clinical manifestations and neurological mechanisms. Neuropsychol Rev 2001;11117- 130. Review
PubMed Link to Article
Hashimoto  RTanaka  Y Contribution of the supplementary motor area and anterior cingulate gyrus to pathological grasping phenomena. Eur Neurol 1998;40151- 158
Link to Article
Okun  MSStover  NPSubramanian  T  et al.  Complications of gamma knife surgery for Parkinson disease. Arch Neurol 2001;581995- 2002
PubMed Link to Article

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 15

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles