A 17-year-old, right-handed young woman presented with a history of highly unusual yet conspicuous changes in her vision. She described normal vision that was recurrently punctuated by a stereotyped illusion characterized by the perception that she was “looking through a kaleidoscope.” Whole-field visual scenes were fragmented into component parts while the patient was still able to accurately identify the visual object. This visual fragmentation occurred paroxysmally as stereotyped episodes over a 1-week period, and it involved both eyes. The initial event lasted approximately 60 minutes, and subsequent episodes were substantially shorter yet indistinguishable in character. There were no associated neurological concomitants such as headache, weakness, numbness, or post-ictal fatigue, and there was no significant medical history. She did have a history of a fall from an all-terrain vehicle at age 14 years, but she did not sustain any injuries. Magnetic resonance imaging at an outside institution at the time of initial presentation revealed a solitary, well-circumscribed hyperintensity localized to the splenium of the corpus callosum (CC). The abnormality was identified on T2-weighted, fluid-attenuated inversion recovery, and diffusion-weighted sequences (Figure 1). There was no evidence of gadolinium enhancement. A magnetic resonance scan of the cervical and thoracic spinal cord was normal. Cerebrospinal fluid IgG index and synthesis rate were normal, and there was no evidence of oligoclonal bands. Results of a comprehensive metabolic panel including liver functions, electrolyte levels, blood glucose level, complete blood cell count, antiphospholipid antibodies, lupus anticoagulants, protein C and S, antithrombin III, factor V Leiden, VDRL test, cryptococcal antigen, antinuclear antibody, rheumatoid factor, erythrocyte sedimentation rate, Lyme titer, serum protein electrophoresis, and immunofixation were all normal. The differential diagnosis of this lesion included neoplasm, gliosis, traumatic axonal injury, Susac syndrome, a metabolic or infectious derangement, Marchiafava Bignami disease, and demyelination. The patient was referred to our neurological surgery and neurology departments for consultation and further workup.